BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

354 related articles for article (PubMed ID: 17942596)

  • 1. Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.
    Pagé EL; Chan DA; Giaccia AJ; Levine M; Richard DE
    Mol Biol Cell; 2008 Jan; 19(1):86-94. PubMed ID: 17942596
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.
    Pan Y; Mansfield KD; Bertozzi CC; Rudenko V; Chan DA; Giaccia AJ; Simon MC
    Mol Cell Biol; 2007 Feb; 27(3):912-25. PubMed ID: 17101781
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.
    Salnikow K; Donald SP; Bruick RK; Zhitkovich A; Phang JM; Kasprzak KS
    J Biol Chem; 2004 Sep; 279(39):40337-44. PubMed ID: 15271983
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.
    Choi SM; Choi KO; Park YK; Cho H; Yang EG; Park H
    J Biol Chem; 2006 Nov; 281(45):34056-63. PubMed ID: 16973622
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH; Stengel P; Doege K; Heikkinen P; Jokilehto T; Wagner T; Jelkmann W; Jaakkola P; Metzen E
    Biochem J; 2004 Aug; 381(Pt 3):761-7. PubMed ID: 15104534
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha.
    André H; Pereira TS
    J Biol Chem; 2008 Oct; 283(43):29375-84. PubMed ID: 18694926
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.
    Pereira T; Zheng X; Ruas JL; Tanimoto K; Poellinger L
    J Biol Chem; 2003 Feb; 278(9):6816-23. PubMed ID: 12468553
    [TBL] [Abstract][Full Text] [Related]  

  • 8. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
    Baek JH; Mahon PC; Oh J; Kelly B; Krishnamachary B; Pearson M; Chan DA; Giaccia AJ; Semenza GL
    Mol Cell; 2005 Feb; 17(4):503-12. PubMed ID: 15721254
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Proline hydroxylation at different sites in hypoxia-inducible factor 1α modulates its interactions with the von Hippel-Lindau tumor suppressor protein.
    Qian H; Zou Y; Tang Y; Gong Y; Qian Z; Wei G; Zhang Q
    Phys Chem Chem Phys; 2018 Jul; 20(27):18756-18765. PubMed ID: 29961792
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Alternative regulation of HIF-1α stability through Phosphorylation on Ser451.
    Han HJ; Saeidi S; Kim SJ; Piao JY; Lim S; Guillen-Quispe YN; Choi BY; Surh YJ
    Biochem Biophys Res Commun; 2021 Mar; 545():150-156. PubMed ID: 33550096
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
    Foxler DE; Bridge KS; James V; Webb TM; Mee M; Wong SC; Feng Y; Constantin-Teodosiu D; Petursdottir TE; Bjornsson J; Ingvarsson S; Ratcliffe PJ; Longmore GD; Sharp TV
    Nat Cell Biol; 2012 Jan; 14(2):201-8. PubMed ID: 22286099
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells.
    Jung DB; Lee HJ; Jeong SJ; Lee HJ; Lee EO; Kim YC; Ahn KS; Chen CY; Kim SH
    Biol Pharm Bull; 2011; 34(6):850-5. PubMed ID: 21628883
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation.
    Park YK; Ahn DR; Oh M; Lee T; Yang EG; Son M; Park H
    Mol Pharmacol; 2008 Jul; 74(1):236-45. PubMed ID: 18426857
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases.
    Metzen E; Zhou J; Jelkmann W; Fandrey J; Brüne B
    Mol Biol Cell; 2003 Aug; 14(8):3470-81. PubMed ID: 12925778
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1.
    To KK; Huang LE
    J Biol Chem; 2005 Nov; 280(45):38102-7. PubMed ID: 16157596
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola P; Mole DR; Tian YM; Wilson MI; Gielbert J; Gaskell SJ; von Kriegsheim A; Hebestreit HF; Mukherji M; Schofield CJ; Maxwell PH; Pugh CW; Ratcliffe PJ
    Science; 2001 Apr; 292(5516):468-72. PubMed ID: 11292861
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.
    Yuan G; Nanduri J; Khan S; Semenza GL; Prabhakar NR
    J Cell Physiol; 2008 Dec; 217(3):674-85. PubMed ID: 18651560
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.
    Snell CE; Turley H; McIntyre A; Li D; Masiero M; Schofield CJ; Gatter KC; Harris AL; Pezzella F
    PLoS One; 2014; 9(2):e88955. PubMed ID: 24563687
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron.
    Callapina M; Zhou J; Schnitzer S; Metzen E; Lohr C; Deitmer JW; Brüne B
    Exp Cell Res; 2005 May; 306(1):274-84. PubMed ID: 15878351
    [TBL] [Abstract][Full Text] [Related]  

  • 20. NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species.
    Callapina M; Zhou J; Schmid T; Köhl R; Brüne B
    Free Radic Biol Med; 2005 Oct; 39(7):925-36. PubMed ID: 16140212
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.