162 related articles for article (PubMed ID: 17944451)
1. Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.
Colucci MA; Reigan P; Siegel D; Chilloux A; Ross D; Moody CJ
J Med Chem; 2007 Nov; 50(23):5780-9. PubMed ID: 17944451
[TBL] [Abstract][Full Text] [Related]
2. Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
Reigan P; Colucci MA; Siegel D; Chilloux A; Moody CJ; Ross D
Biochemistry; 2007 May; 46(20):5941-50. PubMed ID: 17455910
[TBL] [Abstract][Full Text] [Related]
3. 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo.
Dehn DL; Siegel D; Zafar KS; Reigan P; Swann E; Moody CJ; Ross D
Mol Cancer Ther; 2006 Jul; 5(7):1702-9. PubMed ID: 16891456
[TBL] [Abstract][Full Text] [Related]
4. Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.
Swann E; Barraja P; Oberlander AM; Gardipee WT; Hudnott AR; Beall HD; Moody CJ
J Med Chem; 2001 Sep; 44(20):3311-9. PubMed ID: 11563930
[TBL] [Abstract][Full Text] [Related]
5. Indolequinone antitumor agents: correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity.
Beall HD; Winski S; Swann E; Hudnott AR; Cotterill AS; O'Sullivan N; Green SJ; Bien R; Siegel D; Ross D; Moody CJ
J Med Chem; 1998 Nov; 41(24):4755-66. PubMed ID: 9822546
[TBL] [Abstract][Full Text] [Related]
6. Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential.
Colucci MA; Moody CJ; Couch GD
Org Biomol Chem; 2008 Feb; 6(4):637-56. PubMed ID: 18264564
[TBL] [Abstract][Full Text] [Related]
7. Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
Winski SL; Swann E; Hargreaves RH; Dehn DL; Butler J; Moody CJ; Ross D
Biochem Pharmacol; 2001 Jun; 61(12):1509-16. PubMed ID: 11377380
[TBL] [Abstract][Full Text] [Related]
8. Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase.
Newsome JJ; Swann E; Hassani M; Bray KC; Slawin AM; Beall HD; Moody CJ
Org Biomol Chem; 2007 May; 5(10):1629-40. PubMed ID: 17571194
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of novel isothiazoloquinoline quinone analogues.
Chen L; Xie YZ; Luo ZY; Liu LJ; Zou ZZ; Liu HD; Kong FR; Hao Y; Gao JL; Wang LL; Ma DY; Liu SY
Bioorg Med Chem Lett; 2020 Aug; 30(16):127286. PubMed ID: 32631508
[TBL] [Abstract][Full Text] [Related]
10. 2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1).
Bian J; Deng B; Xu L; Xu X; Wang N; Hu T; Yao Z; Du J; Yang L; Lei Y; Li X; Sun H; Zhang X; You Q
Eur J Med Chem; 2014 Jul; 82():56-67. PubMed ID: 24874653
[TBL] [Abstract][Full Text] [Related]
11. Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1.
Kolossov VL; Ponnuraj N; Beaudoin JN; Leslie MT; Kenis PJ; Gaskins HR
Biochem Biophys Res Commun; 2017 Jan; 483(1):680-686. PubMed ID: 27986568
[TBL] [Abstract][Full Text] [Related]
12. Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
Newsome JJ; Hassani M; Swann E; Bibby JM; Beall HD; Moody CJ
Bioorg Med Chem; 2013 Jun; 21(11):2999-3009. PubMed ID: 23635904
[TBL] [Abstract][Full Text] [Related]
13. Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).
Fryatt T; Pettersson HI; Gardipee WT; Bray KC; Green SJ; Slawin AM; Beall HD; Moody CJ
Bioorg Med Chem; 2004 Apr; 12(7):1667-87. PubMed ID: 15028260
[TBL] [Abstract][Full Text] [Related]
14. Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme.
Kadela-Tomanek M; Bębenek E; Chrobak E; Marciniec K; Latocha M; Kuśmierz D; Jastrzębska M; Boryczka S
Eur J Med Chem; 2019 Sep; 177():302-315. PubMed ID: 31158746
[TBL] [Abstract][Full Text] [Related]
15. NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer.
Zhang K; Chen D; Ma K; Wu X; Hao H; Jiang S
J Med Chem; 2018 Aug; 61(16):6983-7003. PubMed ID: 29712428
[TBL] [Abstract][Full Text] [Related]
16. Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential.
Ryu CK; Jeong HJ; Lee SK; You HJ; Choi KU; Shim JY; Heo YH; Lee CO
Arch Pharm Res; 2001 Oct; 24(5):390-6. PubMed ID: 11693537
[TBL] [Abstract][Full Text] [Related]
17. Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities.
Ling Y; Yang QX; Teng YN; Chen S; Gao WJ; Guo J; Hsu PL; Liu Y; Morris-Natschke SL; Hung CC; Lee KH
Eur J Med Chem; 2018 Jun; 154():199-209. PubMed ID: 29803003
[TBL] [Abstract][Full Text] [Related]
18. Kinetics of NAD(P)H:quinone oxidoreductase I (NQO1) inhibition by mitomycin C in vitro and in vivo.
Gustafson DL; Siegel D; Rastatter JC; Merz AL; Parpal JC; Kepa JK; Ross D; Long ME
J Pharmacol Exp Ther; 2003 Jun; 305(3):1079-86. PubMed ID: 12649308
[TBL] [Abstract][Full Text] [Related]
19. Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.
Phillips RM; Naylor MA; Jaffar M; Doughty SW; Everett SA; Breen AG; Choudry GA; Stratford IJ
J Med Chem; 1999 Oct; 42(20):4071-80. PubMed ID: 10514277
[TBL] [Abstract][Full Text] [Related]
20. Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.
Nolan KA; Zhao H; Faulder PF; Frenkel AD; Timson DJ; Siegel D; Ross D; Burke TR; Stratford IJ; Bryce RA
J Med Chem; 2007 Dec; 50(25):6316-25. PubMed ID: 17999461
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]