150 related articles for article (PubMed ID: 17956269)
1. Structure-based optimization of PKCtheta inhibitors.
Mosyak L; Xu Z; Joseph-McCarthy D; Brooijmans N; Somers W; Chaudhary D
Biochem Soc Trans; 2007 Nov; 35(Pt 5):1027-31. PubMed ID: 17956269
[TBL] [Abstract][Full Text] [Related]
2. Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
Cole DC; Asselin M; Brennan A; Czerwinski R; Ellingboe JW; Fitz L; Greco R; Huang X; Joseph-McCarthy D; Kelly MF; Kirisits M; Lee J; Li Y; Morgan P; Stock JR; Tsao DH; Wissner A; Yang X; Chaudhary D
J Med Chem; 2008 Oct; 51(19):5958-63. PubMed ID: 18783200
[TBL] [Abstract][Full Text] [Related]
3. PKCtheta: A potential therapeutic target for T-cell-mediated diseases.
Chaudhary D; Kasaian M
Curr Opin Investig Drugs; 2006 May; 7(5):432-7. PubMed ID: 16729719
[TBL] [Abstract][Full Text] [Related]
4. 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta.
Nathan Tumey L; Boschelli DH; Lee J; Chaudhary D
Bioorg Med Chem Lett; 2008 Aug; 18(15):4420-3. PubMed ID: 18606543
[TBL] [Abstract][Full Text] [Related]
5. First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.
Niu C; Boschelli DH; Tumey LN; Bhagirath N; Subrath J; Shim J; Wang Y; Wu B; Eid C; Lee J; Yang X; Brennan A; Chaudhary D
Bioorg Med Chem Lett; 2009 Oct; 19(20):5829-32. PubMed ID: 19762237
[TBL] [Abstract][Full Text] [Related]
6. Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCtheta inhibitors.
Boschelli DH; Wang D; Prashad AS; Subrath J; Wu B; Niu C; Lee J; Yang X; Brennan A; Chaudhary D
Bioorg Med Chem Lett; 2009 Jul; 19(13):3623-6. PubMed ID: 19447612
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles.
Shim J; Eid C; Lee J; Liu E; Chaudhary D; Boschelli DH
Bioorg Med Chem Lett; 2009 Dec; 19(23):6575-7. PubMed ID: 19854645
[TBL] [Abstract][Full Text] [Related]
8. 5-Vinyl-3-pyridinecarbonitrile inhibitors of PKCtheta: optimization of enzymatic and functional activity.
Tumey LN; Bhagirath N; Brennan A; Brooijmans N; Lee J; Yang X; Boschelli DH
Bioorg Med Chem; 2009 Dec; 17(23):7933-48. PubMed ID: 19884013
[TBL] [Abstract][Full Text] [Related]
9. Discovery of potent and selective PKC-theta inhibitors.
Cywin CL; Dahmann G; Prokopowicz AS; Young ER; Magolda RL; Cardozo MG; Cogan DA; Disalvo D; Ginn JD; Kashem MA; Wolak JP; Homon CA; Farrell TM; Grbic H; Hu H; Kaplita PV; Liu LH; Spero DM; Jeanfavre DD; O'Shea KM; White DM; Woska JR; Brown ML
Bioorg Med Chem Lett; 2007 Jan; 17(1):225-30. PubMed ID: 17055721
[TBL] [Abstract][Full Text] [Related]
10. Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism.
Czerwinski R; Aulabaugh A; Greco RM; Olland S; Malakian K; Wolfrom S; Lin L; Kriz R; Stahl M; Huang Y; Liu L; Chaudhary D
Biochemistry; 2005 Jul; 44(28):9563-73. PubMed ID: 16008341
[TBL] [Abstract][Full Text] [Related]
11. Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit.
George DM; Breinlinger EC; Friedman M; Zhang Y; Wang J; Argiriadi M; Bansal-Pakala P; Barth M; Duignan DB; Honore P; Lang Q; Mittelstadt S; Potin D; Rundell L; Edmunds JJ
J Med Chem; 2015 Jan; 58(1):222-36. PubMed ID: 25000588
[TBL] [Abstract][Full Text] [Related]
12. C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCtheta inhibitors: Part I.
Subrath J; Wang D; Wu B; Niu C; Boschelli DH; Lee J; Yang X; Brennan A; Chaudhary D
Bioorg Med Chem Lett; 2009 Sep; 19(18):5423-5. PubMed ID: 19682896
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and PKCtheta inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles.
Dushin RG; Nittoli T; Ingalls C; Boschelli DH; Cole DC; Wissner A; Lee J; Yang X; Morgan P; Brennan A; Chaudhary D
Bioorg Med Chem Lett; 2009 May; 19(9):2461-3. PubMed ID: 19345579
[TBL] [Abstract][Full Text] [Related]
14. Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Wagner J; von Matt P; Sedrani R; Albert R; Cooke N; Ehrhardt C; Geiser M; Rummel G; Stark W; Strauss A; Cowan-Jacob SW; Beerli C; Weckbecker G; Evenou JP; Zenke G; Cottens S
J Med Chem; 2009 Oct; 52(20):6193-6. PubMed ID: 19827831
[TBL] [Abstract][Full Text] [Related]
15. Optimized protein kinase Cθ (PKCθ) inhibitors reveal only modest anti-inflammatory efficacy in a rodent model of arthritis.
George DM; Breinlinger EC; Argiriadi MA; Zhang Y; Wang J; Bansal-Pakala P; Duignan DB; Honore P; Lang Q; Mittelstadt S; Rundell L; Schwartz A; Sun J; Edmunds JJ
J Med Chem; 2015 Jan; 58(1):333-46. PubMed ID: 25254961
[TBL] [Abstract][Full Text] [Related]
16. Development of selective bisubstrate-based inhibitors against protein kinase C (PKC) isozymes by using dynamic peptide microarrays.
Poot AJ; van Ameijde J; Slijper M; van den Berg A; Hilhorst R; Ruijtenbeek R; Rijkers DT; Liskamp RM
Chembiochem; 2009 Aug; 10(12):2042-51. PubMed ID: 19618415
[TBL] [Abstract][Full Text] [Related]
17. Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases.
Jimenez JM; Boyall D; Brenchley G; Collier PN; Davis CJ; Fraysse D; Keily SB; Henderson J; Miller A; Pierard F; Settimo L; Twin HC; Bolton CM; Curnock AP; Chiu P; Tanner AJ; Young S
J Med Chem; 2013 Mar; 56(5):1799-810. PubMed ID: 23398373
[TBL] [Abstract][Full Text] [Related]
18. C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCtheta inhibitors: part II.
Prashad AS; Wang D; Subrath J; Wu B; Lin M; Zhang MY; Kagan N; Lee J; Yang X; Brennan A; Chaudhary D; Xu X; Leung L; Wang J; Boschelli DH
Bioorg Med Chem Lett; 2009 Oct; 19(19):5799-802. PubMed ID: 19703774
[TBL] [Abstract][Full Text] [Related]
19. Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCtheta inhibitors.
Boschelli DH; Subrath J; Niu C; Wu B; Wang Y; Lee J; Brennan A; Ho M; Deng B; Yang X; Xu X; Leung L; Wang J; Atherton J; Chaudhary D
Bioorg Med Chem Lett; 2010 Mar; 20(6):1965-8. PubMed ID: 20153643
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles.
Boschelli DH; Wu B; Barrios Sosa AC; Chen J; Asselin M; Cole DC; Lee J; Yang X; Chaudhary D
Bioorg Med Chem Lett; 2008 May; 18(9):2850-3. PubMed ID: 18434148
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
