BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

306 related articles for article (PubMed ID: 17956607)

  • 1. The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery.
    Buetow L; Brown AC; Parish T; Hunter WN
    BMC Struct Biol; 2007 Oct; 7():68. PubMed ID: 17956607
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment.
    O'Rourke PE; Kalinowska-Tłuścik J; Fyfe PK; Dawson A; Hunter WN
    BMC Struct Biol; 2014 Jan; 14():1. PubMed ID: 24410837
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Homology modeling of Mycobacterium tuberculosis 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, the third enzyme in the MEP pathway for isoprenoid biosynthesis.
    Obiol-Pardo C; Cordero A; Rubio-Martinez J; Imperial S
    J Mol Model; 2010 Jun; 16(6):1061-73. PubMed ID: 19916033
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF.
    Narayanasamy P; Eoh H; Brennan PJ; Crick DC
    Chem Biol; 2010 Feb; 17(2):117-22. PubMed ID: 20189102
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development.
    Kemp LE; Bond CS; Hunter WN
    Proc Natl Acad Sci U S A; 2002 May; 99(10):6591-6. PubMed ID: 11997478
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target.
    Henriksson LM; Björkelid C; Mowbray SL; Unge T
    Acta Crystallogr D Biol Crystallogr; 2006 Jul; 62(Pt 7):807-13. PubMed ID: 16790937
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.
    Steinbacher S; Kaiser J; Wungsintaweekul J; Hecht S; Eisenreich W; Gerhardt S; Bacher A; Rohdich F
    J Mol Biol; 2002 Feb; 316(1):79-88. PubMed ID: 11829504
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis.
    Shan S; Chen X; Liu T; Zhao H; Rao Z; Lou Z
    FASEB J; 2011 May; 25(5):1577-84. PubMed ID: 21282208
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structure of IspF from
    Liu Z; Jin Y; Liu W; Tao Y; Wang G
    Biosci Rep; 2018 Feb; 38(1):. PubMed ID: 29335298
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum.
    Rohdich F; Eisenreich W; Wungsintaweekul J; Hecht S; Schuhr CA; Bacher A
    Eur J Biochem; 2001 Jun; 268(11):3190-7. PubMed ID: 11389720
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis.
    Gabrielsen M; Bond CS; Hallyburton I; Hecht S; Bacher A; Eisenreich W; Rohdich F; Hunter WN
    J Biol Chem; 2004 Dec; 279(50):52753-61. PubMed ID: 15466439
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.
    Sgraja T; Kemp LE; Ramsden N; Hunter WN
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2005 Jul; 61(Pt 7):625-9. PubMed ID: 16511114
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Biosynthesis of isoprenoids: characterization of a functionally active recombinant 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) from Mycobacterium tuberculosis H37Rv.
    Shi W; Feng J; Zhang M; Lai X; Xu S; Zhang X; Wang H
    J Biochem Mol Biol; 2007 Nov; 40(6):911-20. PubMed ID: 18047786
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy.
    Ramsden NL; Buetow L; Dawson A; Kemp LA; Ulaganathan V; Brenk R; Klebe G; Hunter WN
    J Med Chem; 2009 Apr; 52(8):2531-42. PubMed ID: 19320487
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis.
    Huang H; Berg S; Spencer JS; Vereecke D; D'Haeze W; Holsters M; McNeil MR
    Microbiology (Reading); 2008 Mar; 154(Pt 3):736-743. PubMed ID: 18310020
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery.
    Sgraja T; Alphey MS; Ghilagaber S; Marquez R; Robertson MN; Hemmings JL; Lauw S; Rohdich F; Bacher A; Eisenreich W; Illarionova V; Hunter WN
    FEBS J; 2008 Jun; 275(11):2779-94. PubMed ID: 18422643
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biosynthesis of isoprenoids in plants: structure of the 2C-methyl-D-erithrytol 2,4-cyclodiphosphate synthase from Arabidopsis thaliana. Comparison with the bacterial enzymes.
    Calisto BM; Perez-Gil J; Bergua M; Querol-Audi J; Fita I; Imperial S
    Protein Sci; 2007 Sep; 16(9):2082-8. PubMed ID: 17660251
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni.
    Gabrielsen M; Rohdich F; Eisenreich W; Gräwert T; Hecht S; Bacher A; Hunter WN
    Eur J Biochem; 2004 Jul; 271(14):3028-35. PubMed ID: 15233799
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
    Richard SB; Ferrer JL; Bowman ME; Lillo AM; Tetzlaff CN; Cane DE; Noel JP
    J Biol Chem; 2002 Mar; 277(10):8667-72. PubMed ID: 11786530
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity.
    Bitok JK; Meyers CF
    ACS Chem Biol; 2012 Oct; 7(10):1702-10. PubMed ID: 22839733
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.