BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 17956868)

  • 1. Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A.
    Li D; Fournel-Gigleux S; Barré L; Mulliert G; Netter P; Magdalou J; Ouzzine M
    J Biol Chem; 2007 Dec; 282(50):36514-24. PubMed ID: 17956868
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Importance of histidine residues for the function of the human liver UDP-glucuronosyltransferase UGT1A6: evidence for the catalytic role of histidine 370.
    Ouzzine M; Antonio L; Burchell B; Netter P; Fournel-Gigleux S; Magdalou J
    Mol Pharmacol; 2000 Dec; 58(6):1609-15. PubMed ID: 11093802
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.
    Kerdpin O; Mackenzie PI; Bowalgaha K; Finel M; Miners JO
    Drug Metab Dispos; 2009 Sep; 37(9):1948-55. PubMed ID: 19487247
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases.
    Patana AS; Kurkela M; Finel M; Goldman A
    Protein Eng Des Sel; 2008 Sep; 21(9):537-43. PubMed ID: 18502788
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.
    Kurkela M; Patana AS; Mackenzie PI; Court MH; Tate CG; Hirvonen J; Goldman A; Finel M
    Pharmacogenet Genomics; 2007 Feb; 17(2):115-26. PubMed ID: 17301691
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues.
    Ouzzine M; Gulberti S; Levoin N; Netter P; Magdalou J; Fournel-Gigleux S
    J Biol Chem; 2002 Jul; 277(28):25439-45. PubMed ID: 11986319
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.
    Xiong Y; Patana AS; Miley MJ; Zielinska AK; Bratton SM; Miller GP; Goldman A; Finel M; Redinbo MR; Radominska-Pandya A
    Drug Metab Dispos; 2008 Mar; 36(3):517-22. PubMed ID: 18048489
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4.
    Kubota T; Lewis BC; Elliot DJ; Mackenzie PI; Miners JO
    Mol Pharmacol; 2007 Oct; 72(4):1054-62. PubMed ID: 17636046
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids.
    Pritchard M; Fournel-Gigleux S; Siest G; Mackenzie P; Magdalou J
    Mol Pharmacol; 1994 Jan; 45(1):42-50. PubMed ID: 8302279
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural and functional studies of UDP-glucuronosyltransferases.
    Radominska-Pandya A; Czernik PJ; Little JM; Battaglia E; Mackenzie PI
    Drug Metab Rev; 1999 Nov; 31(4):817-99. PubMed ID: 10575553
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity.
    Korprasertthaworn P; Rowland A; Lewis BC; Mackenzie PI; Yoovathaworn K; Miners JO
    Biochem Pharmacol; 2012 Dec; 84(11):1511-21. PubMed ID: 22981363
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Insights on membrane topology and structure/function of UDP-glucuronosyltransferases.
    Magdalou J; Fournel-Gigleux S; Ouzzine M
    Drug Metab Rev; 2010 Feb; 42(1):159-66. PubMed ID: 19807219
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates.
    Udomuksorn W; Elliot DJ; Lewis BC; Mackenzie PI; Yoovathaworn K; Miners JO
    Pharmacogenet Genomics; 2007 Dec; 17(12):1017-29. PubMed ID: 18004206
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms.
    Sakaguchi K; Green M; Stock N; Reger TS; Zunic J; King C
    Arch Biochem Biophys; 2004 Apr; 424(2):219-25. PubMed ID: 15047194
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1.
    Watanabe Y; Nakajima M; Ohashi N; Kume T; Yokoi T
    Drug Metab Dispos; 2003 May; 31(5):589-95. PubMed ID: 12695347
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin.
    Hanioka N; Ozawa S; Jinno H; Ando M; Saito Y; Sawada J
    Xenobiotica; 2001 Oct; 31(10):687-99. PubMed ID: 11695848
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7.
    Sabolovic N; Magdalou J; Netter P; Abid A
    Life Sci; 2000; 67(2):185-96. PubMed ID: 10901286
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8.
    Strassburg CP; Manns MP; Tukey RH
    J Biol Chem; 1998 Apr; 273(15):8719-26. PubMed ID: 9535849
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin in human liver microsomes.
    Nakajima M; Sakata N; Ohashi N; Kume T; Yokoi T
    Drug Metab Dispos; 2002 Nov; 30(11):1250-6. PubMed ID: 12386132
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4.
    Bruck M; Li Q; Lamb JG; Tukey RH
    Arch Biochem Biophys; 1997 Dec; 348(2):357-64. PubMed ID: 9463278
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.