BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

244 related articles for article (PubMed ID: 17963245)

  • 1. Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth.
    Ecke I; Rosenberger A; Obenauer S; Dullin C; Aberger F; Kimmina S; Schweyer S; Hahn H
    Mol Carcinog; 2008 May; 47(5):361-72. PubMed ID: 17963245
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group.
    Pressey JG; Anderson JR; Crossman DK; Lynch JC; Barr FG
    Pediatr Blood Cancer; 2011 Dec; 57(6):930-8. PubMed ID: 21618411
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.
    Götschel F; Berg D; Gruber W; Bender C; Eberl M; Friedel M; Sonntag J; Rüngeler E; Hache H; Wierling C; Nietfeld W; Lehrach H; Frischauf A; Schwartz-Albiez R; Aberger F; Korf U
    PLoS One; 2013; 8(6):e65403. PubMed ID: 23762360
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.
    Cohen JR; Resnick DZ; Niewiadomski P; Dong H; Liau LM; Waschek JA
    BMC Cancer; 2010 Dec; 10():676. PubMed ID: 21143927
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations.
    Galimberti F; Busch AM; Chinyengetere F; Ma T; Sekula D; Memoli VA; Dragnev KH; Liu F; Johnson KC; Guo Y; Freemantle SJ; Andrew AS; Greninger P; Robbins DJ; Settleman J; Benes C; Dmitrovsky E
    Int J Oncol; 2012 Nov; 41(5):1751-61. PubMed ID: 22923130
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro.
    Wu JY; Xu XF; Xu L; Niu PQ; Wang F; Hu GY; Wang XP; Guo CY
    Hepatogastroenterology; 2011; 58(110-111):1511-8. PubMed ID: 21940310
    [TBL] [Abstract][Full Text] [Related]  

  • 7. LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.
    Zhuang Z; Wang K; Cheng X; Qu X; Jiang B; Li Z; Luo J; Shao Z; Duan T
    PLoS One; 2013; 8(7):e67431. PubMed ID: 23861764
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.
    Uhmann A; Niemann H; Lammering B; Henkel C; Hess I; Nitzki F; Fritsch A; Prüfer N; Rosenberger A; Dullin C; Schraepler A; Reifenberger J; Schweyer S; Pietsch T; Strutz F; Schulz-Schaeffer W; Hahn H
    Mol Cancer Ther; 2011 Nov; 10(11):2179-88. PubMed ID: 21878656
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer.
    Steg A; Amm HM; Novak Z; Frost AR; Johnson MR
    Cancer Biol Ther; 2010 Nov; 10(9):893-902. PubMed ID: 20814245
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy.
    Nitzki F; Tolosa EJ; Cuvelier N; Frommhold A; Salinas-Riester G; Johnsen SA; Fernandez-Zapico ME; Hahn H
    Oncotarget; 2015 Apr; 6(11):9113-24. PubMed ID: 25823816
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Detection of canonical hedgehog signaling in breast cancer by 131-iodine-labeled derivatives of the sonic hedgehog protein.
    Sims-Mourtada J; Yang D; Tworowska I; Larson R; Smith D; Tsao N; Opdenaker L; Mourtada F; Woodward W
    J Biomed Biotechnol; 2012; 2012():639562. PubMed ID: 22811598
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hedgehog signaling pathway is inactive in colorectal cancer cell lines.
    Chatel G; Ganeff C; Boussif N; Delacroix L; Briquet A; Nolens G; Winkler R
    Int J Cancer; 2007 Dec; 121(12):2622-7. PubMed ID: 17683069
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
    Taipale J; Chen JK; Cooper MK; Wang B; Mann RK; Milenkovic L; Scott MP; Beachy PA
    Nature; 2000 Aug; 406(6799):1005-9. PubMed ID: 10984056
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.
    Sanchez P; Ruiz i Altaba A
    Mech Dev; 2005 Feb; 122(2):223-30. PubMed ID: 15652709
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.
    Werminghaus P; Haase M; Hornsby PJ; Schinner S; Schott M; Malendowicz LK; Lammers BJ; Goretzki PE; Müller-Mattheis V; Markus Giessing ; Willenberg HS
    J Steroid Biochem Mol Biol; 2014 Jan; 139():7-15. PubMed ID: 24063979
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hedgehog signal inhibitor forskolin suppresses cell proliferation and tumor growth of human rhabdomyosarcoma xenograft.
    Yamanaka H; Oue T; Uehara S; Fukuzawa M
    J Pediatr Surg; 2011 Feb; 46(2):320-5. PubMed ID: 21292081
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas.
    Tang JY; Xiao TZ; Oda Y; Chang KS; Shpall E; Wu A; So PL; Hebert J; Bikle D; Epstein EH
    Cancer Prev Res (Phila); 2011 May; 4(5):744-51. PubMed ID: 21436386
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice.
    Ecke I; Petry F; Rosenberger A; Tauber S; Mönkemeyer S; Hess I; Dullin C; Kimmina S; Pirngruber J; Johnsen SA; Uhmann A; Nitzki F; Wojnowski L; Schulz-Schaeffer W; Witt O; Hahn H
    Cancer Res; 2009 Feb; 69(3):887-95. PubMed ID: 19155313
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier.
    Rohner A; Spilker ME; Lam JL; Pascual B; Bartkowski D; Li QJ; Yang AH; Stevens G; Xu M; Wells PA; Planken S; Nair S; Sun S
    Mol Cancer Ther; 2012 Jan; 11(1):57-65. PubMed ID: 22084163
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists.
    Chenna V; Hu C; Pramanik D; Aftab BT; Karikari C; Campbell NR; Hong SM; Zhao M; Rudek MA; Khan SR; Rudin CM; Maitra A
    Mol Cancer Ther; 2012 Jan; 11(1):165-73. PubMed ID: 22027695
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.