These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

219 related articles for article (PubMed ID: 17964151)

  • 1. Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.
    Chen CW; Tran JA; Fleck BA; Tucci FC; Jiang W; Chen C
    Bioorg Med Chem Lett; 2007 Dec; 17(24):6825-31. PubMed ID: 17964151
    [TBL] [Abstract][Full Text] [Related]  

  • 2. QSAR study on melanocortin-4 receptors by support vector machine.
    Pourbasheer E; Riahi S; Ganjali MR; Norouzi P
    Eur J Med Chem; 2010 Mar; 45(3):1087-93. PubMed ID: 20031282
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.
    Chen C; Jiang W; Tran JA; Tucci FC; Fleck BA; Markison S; Wen J; Madan A; Hoare SR; Foster AC; Marinkovic D; Chen CW; Arellano M; Saunders J
    Bioorg Med Chem Lett; 2008 Jan; 18(1):129-36. PubMed ID: 18032040
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor.
    Jiang W; Tran JA; Tucci FC; Fleck BA; Hoare SR; Markison S; Wen J; Chen CW; Marinkovic D; Arellano M; Foster AC; Chen C
    Bioorg Med Chem Lett; 2007 Dec; 17(23):6546-52. PubMed ID: 17933528
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.
    Tran JA; Tucci FC; Arellano M; Jiang W; Chen CW; Marinkovic D; Fleck BA; Wen J; Foster AC; Chen C
    Bioorg Med Chem Lett; 2008 Mar; 18(6):1931-8. PubMed ID: 18294847
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Propionylpiperazines as human melanocortin-4 receptor ligands.
    Chen CW; Tran JA; Jiang W; Tucci FC; Arellano M; Wen J; Fleck BA; Marinkovic D; White NS; Pontillo J; Saunders J; Madan A; Foster AC; Chen C
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4800-3. PubMed ID: 16824757
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists.
    Tian X; Mishra RK; Switzer AG; Hu XE; Kim N; Mazur AW; Ebetino FH; Wos JA; Crossdoersen D; Pinney BB; Farmer JA; Sheldon RJ
    Bioorg Med Chem Lett; 2006 Sep; 16(17):4668-73. PubMed ID: 16766182
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Privileged structure based ligands for melanocortin receptors--4,4-disubstituted piperidine derivatives.
    Kuklish SL; Backer RT; Briner K; Doecke CW; Husain S; Mullaney JT; Ornstein PL; Zgombick JM; O'Brien TP; Fisher MJ
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3843-6. PubMed ID: 16697186
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Privileged structure based ligands for melanocortin-4 receptors--aliphatic piperazine derivatives.
    Briner K; Collado I; Fisher MJ; García-Paredes C; Husain S; Kuklish SL; Mateo AI; O'Brien TP; Ornstein PL; Zgombick J; de Frutos O
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3449-53. PubMed ID: 16650763
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.
    Richardson TI; Ornstein PL; Briner K; Fisher MJ; Backer RT; Biggers CK; Clay MP; Emmerson PJ; Hertel LW; Hsiung HM; Husain S; Kahl SD; Lee JA; Lindstrom TD; Martinelli MJ; Mayer JP; Mullaney JT; O'Brien TP; Pawlak JM; Revell KD; Shah J; Zgombick JM; Herr RJ; Melekhov A; Sampson PB; King CH
    J Med Chem; 2004 Jan; 47(3):744-55. PubMed ID: 14736255
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.
    Hong Q; Bakshi RK; Dellureficio J; He S; Ye Z; Dobbelaar PH; Sebhat IK; Guo L; Liu J; Jian T; Tang R; Kalyani RN; Macneil T; Vongs A; Rosenblum CI; Weinberg DH; Peng Q; Tamvakopoulos C; Miller RR; Stearns RA; Cashen D; Martin WJ; Chen AS; Metzger JM; Chen HY; Strack AM; Fong TM; Maclntyre E; Van der Ploeg LH; Wyvratt MJ; Nargund RP
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4483-6. PubMed ID: 20598533
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.
    Chen C; Tucci FC; Jiang W; Tran JA; Fleck BA; Hoare SR; Wen J; Chen T; Johns M; Markison S; Foster AC; Marinkovic D; Chen CW; Arellano M; Harman J; Saunders J; Bozigian H; Marks D
    Bioorg Med Chem; 2008 May; 16(10):5606-18. PubMed ID: 18417348
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.
    Sebhat IK; Lai Y; Barakat K; Ye Z; Tang R; Kalyani RN; Vongs A; Macneil T; Weinberg DH; Cabello MA; Maroto M; Teran A; Fong TM; Van der Ploeg LH; Patchett AA; Nargund RP
    Bioorg Med Chem Lett; 2007 Oct; 17(20):5720-3. PubMed ID: 17768046
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
    He S; Ye Z; Dobbelaar PH; Sebhat IK; Guo L; Liu J; Jian T; Lai Y; Franklin CL; Bakshi RK; Dellureficio JP; Hong Q; Weinberg DH; Macneil T; Tang R; Strack AM; Tamvakopoulos C; Peng Q; Miller RR; Stearns RA; Chen HY; Chen AS; Fong TM; Wyvratt MJ; Nargund RP
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4399-405. PubMed ID: 20598882
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.
    Marinkovic D; Tucci FC; Tran JA; Fleck BA; Wen J; Chen C
    Bioorg Med Chem Lett; 2008 Sep; 18(17):4817-22. PubMed ID: 18682322
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides.
    Fotsch C; Han N; Arasasingham P; Bo Y; Carmouche M; Chen N; Davis J; Goldberg MH; Hale C; Hsieh FY; Kelly MG; Liu Q; Norman MH; Smith DM; Stec M; Tamayo N; Xi N; Xu S; Bannon AW; Baumgartner JW
    Bioorg Med Chem Lett; 2005 Mar; 15(6):1623-7. PubMed ID: 15745810
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor.
    Shi Q; Ornstein PL; Briner K; Richardson TI; Arnold MB; Backer RT; Buckmaster JL; Canada EJ; Doecke CW; Hertel LW; Honigschmidt N; Hsiung HM; Husain S; Kuklish SL; Martinelli MJ; Mullaney JT; O'Brien TP; Reinhard MR; Rothhaar R; Shah J; Wu Z; Xie C; Zgombick JM; Fisher MJ
    Bioorg Med Chem Lett; 2006 May; 16(9):2341-6. PubMed ID: 16297618
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor.
    Tran JA; Chen CW; Jiang W; Tucci FC; Fleck BA; Marinkovic D; Arellano M; Chen C
    Bioorg Med Chem Lett; 2007 Sep; 17(18):5165-70. PubMed ID: 17629702
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides.
    Chu XJ; Bartkovitz D; Danho W; Swistok J; Cheung AW; Kurylko G; Rowan K; Yeon M; Franco L; Qi L; Chen L; Yagaloff K
    Bioorg Med Chem Lett; 2005 Nov; 15(22):4910-4. PubMed ID: 16169218
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor.
    Pontillo J; Tran JA; Arellano M; Fleck BA; Huntley R; Marinkovic D; Lanier M; Nelson J; Parker J; Saunders J; Tucci FC; Jiang W; Chen CW; White NS; Foster AC; Chen C
    Bioorg Med Chem Lett; 2004 Sep; 14(17):4417-23. PubMed ID: 15357964
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.