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5. Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives. Koshio H; Hirayama F; Ishihara T; Kaizawa H; Shigenaga T; Taniuchi Y; Sato K; Moritani Y; Iwatsuki Y; Uemura T; Kaku S; Kawasaki T; Matsumoto Y; Sakamoto S; Tsukamoto S Bioorg Med Chem; 2004 Oct; 12(20):5415-26. PubMed ID: 15388168 [TBL] [Abstract][Full Text] [Related]
6. The discovery of glycine and related amino acid-based factor Xa inhibitors. Kohrt JT; Filipski KJ; Cody WL; Bigge CF; La F; Welch K; Dahring T; Bryant JW; Leonard D; Bolton G; Narasimhan L; Zhang E; Peterson JT; Haarer S; Sahasrabudhe V; Janiczek N; Desiraju S; Hena M; Fiakpui C; Saraswat N; Sharma R; Sun S; Maiti SN; Leadley R; Edmunds JJ Bioorg Med Chem; 2006 Jul; 14(13):4379-92. PubMed ID: 16529937 [TBL] [Abstract][Full Text] [Related]
7. D-phenylglycinol-derived non-covalent factor Xa inhibitors: effect of non-peptidic S4 linkage elements on affinity and anticoagulant activity. Klimkowski VJ; Watson BM; Wiley MR; Liebeschuetz J; Franciskovich JB; Marimuthu J; Bastian JA; Sall DJ; Smallwood JK; Chirgadze NY; Smith GF; Foster RS; Craft T; Sipes P; Chastain M; Sheehan SM Bioorg Med Chem Lett; 2007 Nov; 17(21):5801-5. PubMed ID: 17881231 [TBL] [Abstract][Full Text] [Related]
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10. Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides. Chan C; Borthwick AD; Brown D; Burns-Kurtis CL; Campbell M; Chaudry L; Chung CW; Convery MA; Hamblin JN; Johnstone L; Kelly HA; Kleanthous S; Patikis A; Patel C; Pateman AJ; Senger S; Shah GP; Toomey JR; Watson NS; Weston HE; Whitworth C; Young RJ; Zhou P J Med Chem; 2007 Apr; 50(7):1546-57. PubMed ID: 17338508 [TBL] [Abstract][Full Text] [Related]
11. Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors. Van Huis CA; Bigge CF; Casimiro-Garcia A; Cody WL; Dudley DA; Filipski KJ; Heemstra RJ; Kohrt JT; Narasimhan LS; Schaum RP; Zhang E; Bryant JW; Haarer S; Janiczek N; Leadley RJ; McClanahan T; Thomas Peterson J; Welch KM; Edmunds JJ Chem Biol Drug Des; 2007 Jun; 69(6):444-50. PubMed ID: 17581239 [TBL] [Abstract][Full Text] [Related]
12. 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs. Jia ZJ; Wu Y; Huang W; Zhang P; Clizbe LA; Goldman EA; Sinha U; Arfsten AE; Edwards ST; Alphonso M; Hutchaleelaha A; Scarborough RM; Zhu BY Bioorg Med Chem Lett; 2004 Mar; 14(5):1221-7. PubMed ID: 14980670 [TBL] [Abstract][Full Text] [Related]
13. The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor. Kohrt JT; Bigge CF; Bryant JW; Casimiro-Garcia A; Chi L; Cody WL; Dahring T; Dudley DA; Filipski KJ; Haarer S; Heemstra R; Janiczek N; Narasimhan L; McClanahan T; Peterson JT; Sahasrabudhe V; Schaum R; Van Huis CA; Welch KM; Zhang E; Leadley RJ; Edmunds JJ Chem Biol Drug Des; 2007 Aug; 70(2):100-12. PubMed ID: 17683371 [TBL] [Abstract][Full Text] [Related]
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15. Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa. Fevig JM; Cacciola J; Buriak J; Rossi KA; Knabb RM; Luettgen JM; Wong PC; Bai SA; Wexler RR; Lam PY Bioorg Med Chem Lett; 2006 Jul; 16(14):3755-60. PubMed ID: 16682200 [TBL] [Abstract][Full Text] [Related]
16. Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors. Imaeda Y; Miyawaki T; Sakamoto H; Itoh F; Konishi N; Hiroe K; Kawamura M; Tanaka T; Kubo K Bioorg Med Chem; 2008 Mar; 16(5):2243-60. PubMed ID: 18077174 [TBL] [Abstract][Full Text] [Related]
17. Parallel synthesis and structure-activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors. Bauer SM; Goldman EA; Huang W; Su T; Wang L; Woolfrey J; Wu Y; Zuckett JF; Arfsten A; Huang B; Kothule J; Lin J; May B; Sinha U; Wong PW; Hutchaleelaha A; Scarborough RM; Zhu BY Bioorg Med Chem Lett; 2004 Aug; 14(15):4045-50. PubMed ID: 15225723 [TBL] [Abstract][Full Text] [Related]
18. SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa. Qiao JX; Chang CH; Cheney DL; Morin PE; Wang GZ; King SR; Wang TC; Rendina AR; Luettgen JM; Knabb RM; Wexler RR; Lam PY Bioorg Med Chem Lett; 2007 Aug; 17(16):4419-27. PubMed ID: 17588746 [TBL] [Abstract][Full Text] [Related]
19. Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs. Young RJ; Borthwick AD; Brown D; Burns-Kurtis CL; Campbell M; Chan C; Charbaut M; Chung CW; Convery MA; Kelly HA; Paul King N; Kleanthous S; Mason AM; Pateman AJ; Patikis AN; Pinto IL; Pollard DR; Senger S; Shah GP; Toomey JR; Watson NS; Weston HE Bioorg Med Chem Lett; 2008 Jan; 18(1):23-7. PubMed ID: 18054228 [TBL] [Abstract][Full Text] [Related]
20. Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. Ye B; Arnaiz DO; Chou YL; Griedel BD; Karanjawala R; Lee W; Morrissey MM; Sacchi KL; Sakata ST; Shaw KJ; Wu SC; Zhao Z; Adler M; Cheeseman S; Dole WP; Ewing J; Fitch R; Lentz D; Liang A; Light D; Morser J; Post J; Rumennik G; Subramanyam B; Sullivan ME; Vergona R; Walters J; Wang YX; White KA; Whitlow M; Kochanny MJ J Med Chem; 2007 Jun; 50(13):2967-80. PubMed ID: 17536795 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]