202 related articles for article (PubMed ID: 17978171)
1. Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen.
Blue R; Murcia M; Karan C; Jirousková M; Coller BS
Blood; 2008 Feb; 111(3):1248-56. PubMed ID: 17978171
[TBL] [Abstract][Full Text] [Related]
2. Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.
Blue R; Kowalska MA; Hirsch J; Murcia M; Janczak CA; Harrington A; Jirouskova M; Li J; Fuentes R; Thornton MA; Filizola M; Poncz M; Coller BS
Blood; 2009 Jul; 114(1):195-201. PubMed ID: 19414864
[TBL] [Abstract][Full Text] [Related]
3. Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3.
Blue R; Li J; Steinberger J; Murcia M; Filizola M; Coller BS
J Biol Chem; 2010 Jun; 285(23):17604-13. PubMed ID: 20363746
[TBL] [Abstract][Full Text] [Related]
4. A unique interaction between alphaIIb and beta3 in the head region is essential for outside-in signaling-related functions of alphaIIbbeta3 integrin.
Hauschner H; Landau M; Seligsohn U; Rosenberg N
Blood; 2010 Jun; 115(22):4542-50. PubMed ID: 20308600
[TBL] [Abstract][Full Text] [Related]
5. Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.
Yin H; Litvinov RI; Vilaire G; Zhu H; Li W; Caputo GA; Moore DT; Lear JD; Weisel JW; Degrado WF; Bennett JS
J Biol Chem; 2006 Dec; 281(48):36732-41. PubMed ID: 17032655
[TBL] [Abstract][Full Text] [Related]
6. Integrin αIIb-mediated PI3K/Akt activation in platelets.
Niu H; Chen X; Gruppo RA; Li D; Wang Y; Zhang L; Wang K; Chai W; Sun Y; Ding Z; Gartner TK; Liu J
PLoS One; 2012; 7(10):e47356. PubMed ID: 23082158
[TBL] [Abstract][Full Text] [Related]
7. Comparative efficacy of fibrinogen and platelet supplementation on the in vitro reversibility of competitive glycoprotein IIb/IIIa receptor-directed platelet inhibition.
Li YF; Spencer FA; Becker RC
Am Heart J; 2002 Apr; 143(4):725-32. PubMed ID: 11923812
[TBL] [Abstract][Full Text] [Related]
8. Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen-integrin α
Hsia CH; Lu WJ; Lin KH; Chou DS; Geraldine P; Jayakuma T; Chang NC; Sheu JR
J Cell Mol Med; 2018 Apr; 22(4):2142-2152. PubMed ID: 29369482
[TBL] [Abstract][Full Text] [Related]
9. A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states.
Longhurst CM; White MM; Wilkinson DA; Jennings LK
Eur J Biochem; 1999 Jul; 263(1):104-11. PubMed ID: 10429193
[TBL] [Abstract][Full Text] [Related]
10. A naturally occurring point mutation in the beta3 integrin MIDAS-like domain affects differently alphavbeta3 and alphaIIIbbeta3 receptor function.
Morel-Kopp MC; Melchior C; Chen P; Ammerlaan W; Lecompte T; Kaplan C; Kieffer N
Thromb Haemost; 2001 Dec; 86(6):1425-34. PubMed ID: 11776310
[TBL] [Abstract][Full Text] [Related]
11. Platelet glycoprotein IIb/IIIa antagonists: lessons learned from clinical trials and future directions.
Leclerc JR
Crit Care Med; 2002 May; 30(5 Suppl):S332-40. PubMed ID: 12004256
[TBL] [Abstract][Full Text] [Related]
12. Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in platelets.
Naik MU; Naik TU; Summer R; Naik UP
PLoS One; 2017; 12(5):e0176602. PubMed ID: 28542214
[TBL] [Abstract][Full Text] [Related]
13. A Ser752-->Pro substitution in the cytoplasmic domain of beta3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the alphaIIbbeta3 integrin and the platelet granule pool of fibrinogen.
Nurden P; Poujol C; Winckler J; Combrié R; Caen JP; Nurden AT
Br J Haematol; 2002 Sep; 118(4):1143-51. PubMed ID: 12199799
[TBL] [Abstract][Full Text] [Related]
14. Swing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogen.
Cheng M; Li J; Negri A; Coller BS
PLoS One; 2013; 8(12):e81609. PubMed ID: 24349096
[TBL] [Abstract][Full Text] [Related]
15. Calreticulin-independent regulation of the platelet integrin alphaIIbbeta3 by the KVGFFKR alphaIIb-cytoplasmic motif.
Reilly D; Larkin D; Devocelle M; Fitzgerald DJ; Moran N
Platelets; 2004 Feb; 15(1):43-54. PubMed ID: 14985176
[TBL] [Abstract][Full Text] [Related]
16. Critical residues for ligand binding in blade 2 of the propeller domain of the integrin alphaIIb subunit.
Tamura T; Hato T; Yamanouchi J; Fujita S
Thromb Haemost; 2004 Jan; 91(1):111-8. PubMed ID: 14691576
[TBL] [Abstract][Full Text] [Related]
17. Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation.
Mitchell WB; Li J; Murcia M; Valentin N; Newman PJ; Coller BS
Blood; 2007 May; 109(9):3725-32. PubMed ID: 17209052
[TBL] [Abstract][Full Text] [Related]
18. Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller.
Basani RB; Zhu H; Thornton MA; Soto CS; Degrado WF; Kowalska MA; Bennett JS; Poncz M
Blood; 2009 Jan; 113(4):902-10. PubMed ID: 18987357
[TBL] [Abstract][Full Text] [Related]
19. Mutations in and near the second calcium-binding domain of integrin alphaIIb affect the structure and function of integrin alphaIIbbeta3.
Gidwitz S; Temple B; White GC
Biochem J; 2004 Apr; 379(Pt 2):449-59. PubMed ID: 14670082
[TBL] [Abstract][Full Text] [Related]
20. Tyr178 of beta3 is critical for alphaIIb maturation and macromolecular ligand binding to alphaIIbbeta3.
Sun CX; Chen P; Lu W; Liu JN
Thromb Res; 2008; 122(2):203-10. PubMed ID: 18201749
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
