BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 17987111)

  • 1. The R403Q myosin mutation implicated in familial hypertrophic cardiomyopathy causes disorder at the actomyosin interface.
    Volkmann N; Lui H; Hazelwood L; Trybus KM; Lowey S; Hanein D
    PLoS One; 2007 Nov; 2(11):e1123. PubMed ID: 17987111
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.
    Lowey S; Bretton V; Gulick J; Robbins J; Trybus KM
    J Biol Chem; 2013 May; 288(21):14780-7. PubMed ID: 23580644
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.
    Lowey S; Lesko LM; Rovner AS; Hodges AR; White SL; Low RB; Rincon M; Gulick J; Robbins J
    J Biol Chem; 2008 Jul; 283(29):20579-89. PubMed ID: 18480046
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hypertrophic cardiomyopathy R403Q mutation in rabbit β-myosin reduces contractile function at the molecular and myofibrillar levels.
    Lowey S; Bretton V; Joel PB; Trybus KM; Gulick J; Robbins J; Kalganov A; Cornachione AS; Rassier DE
    Proc Natl Acad Sci U S A; 2018 Oct; 115(44):11238-11243. PubMed ID: 30322937
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy.
    Yamashita H; Tyska MJ; Warshaw DM; Lowey S; Trybus KM
    J Biol Chem; 2000 Sep; 275(36):28045-52. PubMed ID: 10882745
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Point mutations in human beta cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: an ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly.
    Becker KD; Gottshall KR; Hickey R; Perriard JC; Chien KR
    J Cell Biol; 1997 Apr; 137(1):131-40. PubMed ID: 9105042
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biological, biochemical, and kinetic effects of mutations of the cardiomyopathy loop of Dictyostelium myosin II: importance of ALA400.
    Liu X; Shu S; Kovács M; Korn ED
    J Biol Chem; 2005 Jul; 280(29):26974-83. PubMed ID: 15897189
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional consequences of mutations in the myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy.
    Lowey S
    Trends Cardiovasc Med; 2002 Nov; 12(8):348-54. PubMed ID: 12536121
    [TBL] [Abstract][Full Text] [Related]  

  • 9. R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level.
    Palmiter KA; Tyska MJ; Haeberle JR; Alpert NR; Fananapazir L; Warshaw DM
    J Muscle Res Cell Motil; 2000; 21(7):609-20. PubMed ID: 11227787
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
    Blanchard E; Seidman C; Seidman JG; LeWinter M; Maughan D
    Circ Res; 1999 Mar; 84(4):475-83. PubMed ID: 10066683
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.
    Nag S; Sommese RF; Ujfalusi Z; Combs A; Langer S; Sutton S; Leinwand LA; Geeves MA; Ruppel KM; Spudich JA
    Sci Adv; 2015 Oct; 1(9):e1500511. PubMed ID: 26601291
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils.
    Belus A; Piroddi N; Scellini B; Tesi C; D'Amati G; Girolami F; Yacoub M; Cecchi F; Olivotto I; Poggesi C
    J Physiol; 2008 Aug; 586(15):3639-44. PubMed ID: 18565996
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium.
    Palmer BM; Fishbaugher DE; Schmitt JP; Wang Y; Alpert NR; Seidman CE; Seidman JG; VanBuren P; Maughan DW
    Am J Physiol Heart Circ Physiol; 2004 Jul; 287(1):H91-9. PubMed ID: 15001446
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evidence for cleft closure in actomyosin upon ADP release.
    Volkmann N; Hanein D; Ouyang G; Trybus KM; DeRosier DJ; Lowey S
    Nat Struct Biol; 2000 Dec; 7(12):1147-55. PubMed ID: 11101898
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The left and right ventricle of a patient with a R723G mutation of the beta-myosin heavy chain and severe hypertrophic cardiomyopathy show no differences in the expression of myosin mRNA.
    Borchert B; Tripathi S; Francino A; Navarro-Lopez F; Kraft T
    Cardiol J; 2010; 17(5):518-22. PubMed ID: 20865685
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry.
    Greenberg MJ; Kazmierczak K; Szczesna-Cordary D; Moore JR
    Proc Natl Acad Sci U S A; 2010 Oct; 107(40):17403-8. PubMed ID: 20855589
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutations in the motor domain modulate myosin activity and myofibril organization.
    Wang Q; Moncman CL; Winkelmann DA
    J Cell Sci; 2003 Oct; 116(Pt 20):4227-38. PubMed ID: 12953063
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy.
    Straceski AJ; Geisterfer-Lowrance A; Seidman CE; Seidman JG; Leinwand LA
    Proc Natl Acad Sci U S A; 1994 Jan; 91(2):589-93. PubMed ID: 8290568
    [TBL] [Abstract][Full Text] [Related]  

  • 19. E22K mutation of RLC that causes familial hypertrophic cardiomyopathy in heterozygous mouse myocardium: effect on cross-bridge kinetics.
    Dumka D; Talent J; Akopova I; Guzman G; Szczesna-Cordary D; Borejdo J
    Am J Physiol Heart Circ Physiol; 2006 Nov; 291(5):H2098-106. PubMed ID: 16751284
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy.
    Tyska MJ; Hayes E; Giewat M; Seidman CE; Seidman JG; Warshaw DM
    Circ Res; 2000 Apr; 86(7):737-44. PubMed ID: 10764406
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.