These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

265 related articles for article (PubMed ID: 17987523)

  • 1. Recent progress in the development of allosteric modulators of mGluR5.
    Rodriguez AL; Williams R
    Curr Opin Drug Discov Devel; 2007 Nov; 10(6):715-22. PubMed ID: 17987523
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Recent progress in the discovery and development of negative allosteric modulators of mGluR5.
    Lindsley CW; Emmitte KA
    Curr Opin Drug Discov Devel; 2009 Jul; 12(4):446-57. PubMed ID: 19562641
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
    Duplantier AJ; Efremov I; Candler J; Doran AC; Ganong AH; Haas JA; Hanks AN; Kraus KG; Lazzaro JT; Lu J; Maklad N; McCarthy SA; O'Sullivan TJ; Rogers BN; Siuciak JA; Spracklin DK; Zhang L
    Bioorg Med Chem Lett; 2009 May; 19(9):2524-9. PubMed ID: 19328692
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential.
    Kew JN
    Pharmacol Ther; 2004 Dec; 104(3):233-44. PubMed ID: 15556676
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
    O'Brien JA; Lemaire W; Chen TB; Chang RS; Jacobson MA; Ha SN; Lindsley CW; Schaffhauser HJ; Sur C; Pettibone DJ; Conn PJ; Williams DL
    Mol Pharmacol; 2003 Sep; 64(3):731-40. PubMed ID: 12920211
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.
    Zhang L; Rogers BN; Duplantier AJ; McHardy SF; Efremov I; Berke H; Qian W; Zhang AQ; Maklad N; Candler J; Doran AC; Lazzaro JT; Ganong AH
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5493-6. PubMed ID: 18812259
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists.
    Johnson MP; Nisenbaum ES; Large TH; Emkey R; Baez M; Kingston AE
    Biochem Soc Trans; 2004 Nov; 32(Pt 5):881-7. PubMed ID: 15494040
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.
    Xiong H; Brugel TA; Balestra M; Brown DG; Brush KA; Hightower C; Hinkley L; Hoesch V; Kang J; Koether GM; McCauley JP; McLaren FM; Panko LM; Simpson TR; Smith RW; Woods JM; Brockel B; Chhajlani V; Gadient RA; Spear N; Sygowski LA; Zhang M; Arora J; Breysse N; Wilson JM; Isaac M; Slassi A; King MM
    Bioorg Med Chem Lett; 2010 Dec; 20(24):7381-4. PubMed ID: 21067920
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1.
    Noeske T; Trifanova D; Kauss V; Renner S; Parsons CG; Schneider G; Weil T
    Bioorg Med Chem; 2009 Aug; 17(15):5708-15. PubMed ID: 19574055
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.
    Zhao Z; Wisnoski DD; O'Brien JA; Lemaire W; Williams DL; Jacobson MA; Wittman M; Ha SN; Schaffhauser H; Sur C; Pettibone DJ; Duggan ME; Conn PJ; Hartman GD; Lindsley CW
    Bioorg Med Chem Lett; 2007 Mar; 17(5):1386-91. PubMed ID: 17210250
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
    Lindsley CW; Wisnoski DD; Leister WH; O'brien JA; Lemaire W; Williams DL; Burno M; Sur C; Kinney GG; Pettibone DJ; Tiller PR; Smith S; Duggan ME; Hartman GD; Conn PJ; Huff JR
    J Med Chem; 2004 Nov; 47(24):5825-8. PubMed ID: 15537338
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction.
    Carroll FI
    Ann N Y Acad Sci; 2008 Oct; 1141():221-32. PubMed ID: 18991960
    [TBL] [Abstract][Full Text] [Related]  

  • 13. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
    Chen Y; Goudet C; Pin JP; Conn PJ
    Mol Pharmacol; 2008 Mar; 73(3):909-18. PubMed ID: 18056795
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Metabotropic glutamate receptors for new treatments in schizophrenia.
    Herman EJ; Bubser M; Conn PJ; Jones CK
    Handb Exp Pharmacol; 2012; (213):297-365. PubMed ID: 23027420
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.
    Ritzén A; Mathiesen JM; Thomsen C
    Basic Clin Pharmacol Toxicol; 2005 Oct; 97(4):202-13. PubMed ID: 16176554
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Efficacy switching SAR of mGluR5 allosteric modulators: highly potent positive and negative modulators from one chemotype.
    Sams AG; Mikkelsen GK; Brodbeck RM; Pu X; Ritzén A
    Bioorg Med Chem Lett; 2011 Jun; 21(11):3407-10. PubMed ID: 21531137
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders.
    Gregory KJ; Noetzel MJ; Niswender CM
    Prog Mol Biol Transl Sci; 2013; 115():61-121. PubMed ID: 23415092
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.
    Ritzén A; Sindet R; Hentzer M; Svendsen N; Brodbeck RM; Bundgaard C
    Bioorg Med Chem Lett; 2009 Jun; 19(12):3275-8. PubMed ID: 19443216
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.
    Sharma S; Rodriguez AL; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4098-101. PubMed ID: 18550372
    [TBL] [Abstract][Full Text] [Related]  

  • 20. mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents.
    Rocher JP; Bonnet B; Boléa C; Lütjens R; Le Poul E; Poli S; Epping-Jordan M; Bessis AS; Ludwig B; Mutel V
    Curr Top Med Chem; 2011; 11(6):680-95. PubMed ID: 21261592
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.