BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

324 related articles for article (PubMed ID: 17992257)

  • 1. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis.
    Hickey MM; Lam JC; Bezman NA; Rathmell WK; Simon MC
    J Clin Invest; 2007 Dec; 117(12):3879-89. PubMed ID: 17992257
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.
    Hickey MM; Richardson T; Wang T; Mosqueira M; Arguiri E; Yu H; Yu QC; Solomides CC; Morrisey EE; Khurana TS; Christofidou-Solomidou M; Simon MC
    J Clin Invest; 2010 Mar; 120(3):827-39. PubMed ID: 20197624
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia.
    van Rooijen E; Voest EE; Logister I; Korving J; Schwerte T; Schulte-Merker S; Giles RH; van Eeden FJ
    Blood; 2009 Jun; 113(25):6449-60. PubMed ID: 19304954
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The homozygous VHL(D126N) missense mutation is associated with dramatically elevated erythropoietin levels, consequent polycythemia, and early onset severe pulmonary hypertension.
    Sarangi S; Lanikova L; Kapralova K; Acharya S; Swierczek S; Lipton JM; Wolfe L; Prchal JT
    Pediatr Blood Cancer; 2014 Nov; 61(11):2104-6. PubMed ID: 24729484
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W).
    Tomasic NL; Piterkova L; Huff C; Bilic E; Yoon D; Miasnikova GY; Sergueeva AI; Niu X; Nekhai S; Gordeuk V; Prchal JT
    Haematologica; 2013 Apr; 98(4):560-7. PubMed ID: 23403324
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism.
    McClain DA; Abuelgasim KA; Nouraie M; Salomon-Andonie J; Niu X; Miasnikova G; Polyakova LA; Sergueeva A; Okhotin DJ; Cherqaoui R; Okhotin D; Cox JE; Swierczek S; Song J; Simon MC; Huang J; Simcox JA; Yoon D; Prchal JT; Gordeuk VR
    J Mol Med (Berl); 2013 Jan; 91(1):59-67. PubMed ID: 23015148
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M; Haas R; Brauch H; Acker T; Flamme I; Plate KH
    Oncogene; 2000 Nov; 19(48):5435-43. PubMed ID: 11114720
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing.
    Zhang X; Zhang W; Ma SF; Miasniakova G; Sergueeva A; Ammosova T; Xu M; Nekhai S; Nourai M; Wade MS; Prchal JT; Garcia JGN; Machado RF; Gordeuk VR
    Blood Cells Mol Dis; 2014 Jan; 52(1):35-45. PubMed ID: 23993337
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis.
    Semenza GL
    Blood; 2009 Sep; 114(10):2015-9. PubMed ID: 19494350
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia.
    Pastore Y; Jedlickova K; Guan Y; Liu E; Fahner J; Hasle H; Prchal JF; Prchal JT
    Am J Hum Genet; 2003 Aug; 73(2):412-9. PubMed ID: 12844285
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors.
    Gordeuk VR; Sergueeva AI; Miasnikova GY; Okhotin D; Voloshin Y; Choyke PL; Butman JA; Jedlickova K; Prchal JT; Polyakova LA
    Blood; 2004 May; 103(10):3924-32. PubMed ID: 14726398
    [TBL] [Abstract][Full Text] [Related]  

  • 12. VHL gene methylation contributes to excessive erythrocytosis in chronic mountain sickness rat model by upregulating the HIF-2α/EPO pathway.
    Yang M; Zhu M; Song K; Wuren T; Yan J; Ge RL; Ji L; Cui S
    Life Sci; 2021 Feb; 266():118873. PubMed ID: 33309718
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The relationship of erythropoietin overexpression with von Hippel-Lindau tumour suppressor gene mutations between hypoxia-inducible factor-1α and -2α in sporadic clear cell renal carcinoma.
    Gong K; Zhang N; Zhang K; Na Y
    Int J Mol Med; 2010 Dec; 26(6):907-12. PubMed ID: 21042786
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation.
    Formenti F; Beer PA; Croft QP; Dorrington KL; Gale DP; Lappin TR; Lucas GS; Maher ER; Maxwell PH; McMullin MF; O'Connor DF; Percy MJ; Pugh CW; Ratcliffe PJ; Smith TG; Talbot NP; Robbins PA
    FASEB J; 2011 Jun; 25(6):2001-11. PubMed ID: 21389259
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression.
    Gordeuk VR; Miasnikova GY; Sergueeva AI; Niu X; Nouraie M; Okhotin DJ; Polyakova LA; Ammosova T; Nekhai S; Ganz T; Prchal JT
    Blood; 2011 Nov; 118(19):5278-82. PubMed ID: 21876117
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Therapeutic inhibition of HIF-2α reverses polycythemia and pulmonary hypertension in murine models of human diseases.
    Ghosh MC; Zhang DL; Ollivierre WH; Noguchi A; Springer DA; Linehan WM; Rouault TA
    Blood; 2021 May; 137(18):2509-2519. PubMed ID: 33512384
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Action of hypoxia-inducible factor in liver and kidney from mice with Pax8-rtTA-based deletion of von Hippel-Lindau protein.
    Mathia S; Paliege A; Koesters R; Peters H; Neumayer HH; Bachmann S; Rosenberger C
    Acta Physiol (Oxf); 2013 Mar; 207(3):565-76. PubMed ID: 23384425
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Altered cytokine profiles in patients with Chuvash polycythemia.
    Niu X; Miasnikova GY; Sergueeva AI; Polyakova LA; Okhotin DJ; Tuktanov NV; Nouraie M; Ammosova T; Nekhai S; Gordeuk VR
    Am J Hematol; 2009 Feb; 84(2):74-8. PubMed ID: 19062180
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations.
    Rathmell WK; Hickey MM; Bezman NA; Chmielecki CA; Carraway NC; Simon MC
    Cancer Res; 2004 Dec; 64(23):8595-603. PubMed ID: 15574766
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.
    Russell RC; Sufan RI; Zhou B; Heir P; Bunda S; Sybingco SS; Greer SN; Roche O; Heathcote SA; Chow VW; Boba LM; Richmond TD; Hickey MM; Barber DL; Cheresh DA; Simon MC; Irwin MS; Kim WY; Ohh M
    Nat Med; 2011 Jun; 17(7):845-53. PubMed ID: 21685897
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.