BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

491 related articles for article (PubMed ID: 17998298)

  • 1. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.
    Svecova L; Vrzal R; Burysek L; Anzenbacherova E; Cerveny L; Grim J; Trejtnar F; Kunes J; Pour M; Staud F; Anzenbacher P; Dvorak Z; Pavek P
    Drug Metab Dispos; 2008 Feb; 36(2):339-48. PubMed ID: 17998298
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
    Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T; Chiang JY
    Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Drug-drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibition.
    Dvorak Z
    Toxicol Lett; 2011 Apr; 202(2):129-32. PubMed ID: 21333771
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
    Koyano S; Kurose K; Saito Y; Ozawa S; Hasegawa R; Komamura K; Ueno K; Kamakura S; Kitakaze M; Nakajima T; Matsumoto K; Akasawa A; Saito H; Sawada J
    Drug Metab Dispos; 2004 Jan; 32(1):149-54. PubMed ID: 14709632
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes.
    Song X; Xie M; Zhang H; Li Y; Sachdeva K; Yan B
    Drug Metab Dispos; 2004 Jan; 32(1):35-42. PubMed ID: 14709618
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
    Kim S; Dinchuk JE; Anthony MN; Orcutt T; Zoeckler ME; Sauer MB; Mosure KW; Vuppugalla R; Grace JE; Simmermacher J; Dulac HA; Pizzano J; Sinz M
    Drug Metab Dispos; 2010 Jan; 38(1):16-24. PubMed ID: 19833845
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
    Chang HY; Chen CJ; Ma WC; Cheng WK; Lin YN; Lee YR; Chen JJ; Lim YP
    Phytomedicine; 2017 Dec; 36():37-49. PubMed ID: 29157826
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.
    Sane RS; Buckley DJ; Buckley AR; Nallani SC; Desai PB
    Drug Metab Dispos; 2008 May; 36(5):946-54. PubMed ID: 18299335
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha.
    Liu FJ; Song X; Yang D; Deng R; Yan B
    Biochem J; 2008 Jan; 409(1):243-50. PubMed ID: 17764444
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction.
    Lim YP; Kuo SC; Lai ML; Huang JD
    Pharmacogenet Genomics; 2009 Jan; 19(1):11-24. PubMed ID: 19077665
    [TBL] [Abstract][Full Text] [Related]  

  • 12. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells.
    Tan H; Xu C; Zeng H; Wang Y; Li Y; Fan X; Chen P; Jiang Y; Chen X; Huang M; Bi H
    J Pharmacol Sci; 2016 Feb; 130(2):66-71. PubMed ID: 26782648
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
    Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
    Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.
    Rasmussen MK; Daujat-Chavanieu M; Gerbal-Chaloin S
    Toxicol Lett; 2017 Aug; 277():1-8. PubMed ID: 28571685
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.
    Fang HL; Strom SC; Ellis E; Duanmu Z; Fu J; Duniec-Dmuchowski Z; Falany CN; Falany JL; Kocarek TA; Runge-Morris M
    J Pharmacol Exp Ther; 2007 Nov; 323(2):586-98. PubMed ID: 17687072
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1.
    Lim YP; Huang JD
    Pharmacogenet Genomics; 2007 May; 17(5):369-82. PubMed ID: 17429319
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics.
    Takeshita A; Taguchi M; Koibuchi N; Ozawa Y
    J Biol Chem; 2002 Sep; 277(36):32453-8. PubMed ID: 12072427
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.
    Duret C; Daujat-Chavanieu M; Pascussi JM; Pichard-Garcia L; Balaguer P; Fabre JM; Vilarem MJ; Maurel P; Gerbal-Chaloin S
    Mol Pharmacol; 2006 Jul; 70(1):329-39. PubMed ID: 16608920
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system.
    Raucy J; Warfe L; Yueh MF; Allen SW
    J Pharmacol Exp Ther; 2002 Oct; 303(1):412-23. PubMed ID: 12235278
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element.
    El-Sankary W; Bombail V; Gibson GG; Plant N
    Drug Metab Dispos; 2002 Sep; 30(9):1029-34. PubMed ID: 12167569
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 25.