383 related articles for article (PubMed ID: 18004874)
1. BetaQ114N and betaT110V mutations reveal a critically important role of the substrate alpha-carboxylate site in the reaction specificity of tryptophan synthase.
Blumenstein L; Domratcheva T; Niks D; Ngo H; Seidel R; Dunn MF; Schlichting I
Biochemistry; 2007 Dec; 46(49):14100-16. PubMed ID: 18004874
[TBL] [Abstract][Full Text] [Related]
2. Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands.
Ngo H; Kimmich N; Harris R; Niks D; Blumenstein L; Kulik V; Barends TR; Schlichting I; Dunn MF
Biochemistry; 2007 Jul; 46(26):7740-53. PubMed ID: 17559232
[TBL] [Abstract][Full Text] [Related]
3. Allosteric communication in the tryptophan synthase bienzyme complex: roles of the beta-subunit aspartate 305-arginine 141 salt bridge.
Ferrari D; Niks D; Yang LH; Miles EW; Dunn MF
Biochemistry; 2003 Jul; 42(25):7807-18. PubMed ID: 12820890
[TBL] [Abstract][Full Text] [Related]
4. Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60.
Rhee S; Miles EW; Mozzarelli A; Davies DR
Biochemistry; 1998 Jul; 37(30):10653-9. PubMed ID: 9692955
[TBL] [Abstract][Full Text] [Related]
5. Allosteric regulation of tryptophan synthase channeling: the internal aldimine probed by trans-3-indole-3'-acrylate binding.
Casino P; Niks D; Ngo H; Pan P; Brzovic P; Blumenstein L; Barends TR; Schlichting I; Dunn MF
Biochemistry; 2007 Jul; 46(26):7728-39. PubMed ID: 17559231
[TBL] [Abstract][Full Text] [Related]
6. Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes.
Rhee S; Parris KD; Hyde CC; Ahmed SA; Miles EW; Davies DR
Biochemistry; 1997 Jun; 36(25):7664-80. PubMed ID: 9201907
[TBL] [Abstract][Full Text] [Related]
7. beta-Site covalent reactions trigger transitions between open and closed conformations of the tryptophan synthase bienzyme complex.
Pan P; Dunn MF
Biochemistry; 1996 Apr; 35(15):5002-13. PubMed ID: 8664293
[TBL] [Abstract][Full Text] [Related]
8. Mechanisms of monovalent cation action in enzyme catalysis: the first stage of the tryptophan synthase beta-reaction.
Woehl E; Dunn MF
Biochemistry; 1999 Jun; 38(22):7118-30. PubMed ID: 10353822
[TBL] [Abstract][Full Text] [Related]
9. Allosteric regulation of tryptophan synthase: effects of pH, temperature, and alpha-subunit ligands on the equilibrium distribution of pyridoxal 5'-phosphate-L-serine intermediates.
Peracchi A; Bettati S; Mozzarelli A; Rossi GL; Miles EW; Dunn MF
Biochemistry; 1996 Feb; 35(6):1872-80. PubMed ID: 8639669
[TBL] [Abstract][Full Text] [Related]
10. Affinities of phosphorylated substrates for the E. coli tryptophan synthase alpha-subunit: roles of Ser-235 and helix-8' dipole.
Sarker KD; Hardman JK
Proteins; 1995 Feb; 21(2):130-9. PubMed ID: 7777488
[TBL] [Abstract][Full Text] [Related]
11. Evidence of a low-barrier hydrogen bond in the tryptophan synthase catalytic mechanism.
Hur O; Leja C; Dunn MF
Biochemistry; 1996 Jun; 35(23):7378-86. PubMed ID: 8652514
[TBL] [Abstract][Full Text] [Related]
12. Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity.
Ferrari D; Yang LH; Miles EW; Dunn MF
Biochemistry; 2001 Jun; 40(25):7421-32. PubMed ID: 11412095
[TBL] [Abstract][Full Text] [Related]
13. Loop closure and intersubunit communication in tryptophan synthase.
Schneider TR; Gerhardt E; Lee M; Liang PH; Anderson KS; Schlichting I
Biochemistry; 1998 Apr; 37(16):5394-406. PubMed ID: 9548921
[TBL] [Abstract][Full Text] [Related]
14. Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes.
Chattopadhyay A; Meier M; Ivaninskii S; Burkhard P; Speroni F; Campanini B; Bettati S; Mozzarelli A; Rabeh WM; Li L; Cook PF
Biochemistry; 2007 Jul; 46(28):8315-30. PubMed ID: 17583914
[TBL] [Abstract][Full Text] [Related]
15. The reaction of indole with the aminoacrylate intermediate of Salmonella typhimurium tryptophan synthase: observation of a primary kinetic isotope effect with 3-[(2)H]indole.
Cash MT; Miles EW; Phillips RS
Arch Biochem Biophys; 2004 Dec; 432(2):233-43. PubMed ID: 15542062
[TBL] [Abstract][Full Text] [Related]
16. Cooperative fluctuations and subunit communication in tryptophan synthase.
Bahar I; Jernigan RL
Biochemistry; 1999 Mar; 38(12):3478-90. PubMed ID: 10090734
[TBL] [Abstract][Full Text] [Related]
17. Circular dichroism studies of the coenzyme environment in the active sites of mutant forms of the beta-subunit in the tryptophan synthase alpha 2 beta 2 complex.
Kayastha AM; Sawa Y; Nagata S; Kanzaki H; Miles EW
Indian J Biochem Biophys; 1991; 28(5-6):352-7. PubMed ID: 1812066
[TBL] [Abstract][Full Text] [Related]
18. Mutations in the contact region between the alpha and beta subunits of tryptophan synthase alter subunit interaction and intersubunit communication.
Rowlett R; Yang LH; Ahmed SA; McPhie P; Jhee KH; Miles EW
Biochemistry; 1998 Mar; 37(9):2961-8. PubMed ID: 9485448
[TBL] [Abstract][Full Text] [Related]
19. Tryptophan synthase: the workings of a channeling nanomachine.
Dunn MF; Niks D; Ngo H; Barends TR; Schlichting I
Trends Biochem Sci; 2008 Jun; 33(6):254-64. PubMed ID: 18486479
[TBL] [Abstract][Full Text] [Related]
20. Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium.
Burkhard P; Tai CH; Ristroph CM; Cook PF; Jansonius JN
J Mol Biol; 1999 Aug; 291(4):941-53. PubMed ID: 10452898
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
