BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

78 related articles for article (PubMed ID: 18005660)

  • 1. The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.
    Muñoz-Martínez F; Torres C; Castanys S; Gamarro F
    Biochim Biophys Acta; 2008 Feb; 1778(2):530-40. PubMed ID: 18005660
    [TBL] [Abstract][Full Text] [Related]  

  • 2. CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells.
    Muñoz-Martínez F; Torres C; Castanys S; Gamarro F
    Biochem Pharmacol; 2010 Sep; 80(6):793-800. PubMed ID: 20510206
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.
    Vink SR; van der Luit AH; Klarenbeek JB; Verheij M; van Blitterswijk WJ
    Biochem Pharmacol; 2007 Nov; 74(10):1456-65. PubMed ID: 17803969
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Anticancer mechanisms and clinical application of alkylphospholipids.
    van Blitterswijk WJ; Verheij M
    Biochim Biophys Acta; 2013 Mar; 1831(3):663-74. PubMed ID: 23137567
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.
    van der Luit AH; Vink SR; Klarenbeek JB; Perrissoud D; Solary E; Verheij M; van Blitterswijk WJ
    Mol Cancer Ther; 2007 Aug; 6(8):2337-45. PubMed ID: 17699729
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma.
    Kumar A; Fillmore HL; Kadian R; Broaddus WC; Tye GW; Van Meter TE
    Mol Cancer Res; 2009 Nov; 7(11):1813-21. PubMed ID: 19887560
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.
    Chiarini F; Del Sole M; Mongiorgi S; Gaboardi GC; Cappellini A; Mantovani I; Follo MY; McCubrey JA; Martelli AM
    Leukemia; 2008 Jun; 22(6):1106-16. PubMed ID: 18385752
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid.
    Vink SR; Schellens JH; van Blitterswijk WJ; Verheij M
    Invest New Drugs; 2005 Aug; 23(4):279-86. PubMed ID: 16012787
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.
    Patel V; Lahusen T; Sy T; Sausville EA; Gutkind JS; Senderowicz AM
    Cancer Res; 2002 Mar; 62(5):1401-9. PubMed ID: 11888912
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism.
    Elrod HA; Yue P; Khuri FR; Sun SY
    Mol Cancer Ther; 2009 Sep; 8(9):2575-85. PubMed ID: 19755515
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts.
    Vink SR; Lagerwerf S; Mesman E; Schellens JH; Begg AC; van Blitterswijk WJ; Verheij M
    Clin Cancer Res; 2006 Mar; 12(5):1615-22. PubMed ID: 16533789
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines.
    Dasmahapatra GP; Didolkar P; Alley MC; Ghosh S; Sausville EA; Roy KK
    Clin Cancer Res; 2004 Aug; 10(15):5242-52. PubMed ID: 15297428
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine.
    Hanson PK; Malone L; Birchmore JL; Nichols JW
    J Biol Chem; 2003 Sep; 278(38):36041-50. PubMed ID: 12842877
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation.
    Engel JB; Honig A; Schönhals T; Weidler C; Häusler S; Krockenberger M; Grunewald TG; Dombrowski Y; Rieger L; Dietl J; Wischhusen J
    Eur J Obstet Gynecol Reprod Biol; 2008 Nov; 141(1):64-9. PubMed ID: 18687514
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Upregulation of the eIF4E signaling pathway contributes to the progression of gastric cancer, and targeting eIF4E by perifosine inhibits cell growth.
    Liang S; Guo R; Zhang Z; Liu D; Xu H; Xu Z; Wang X; Yang L
    Oncol Rep; 2013 Jun; 29(6):2422-30. PubMed ID: 23588929
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Current view on the mechanism of action of perifosine in cancer.
    Fensterle J; Aicher B; Seipelt I; Teifel M; Engel J
    Anticancer Agents Med Chem; 2014 May; 14(4):629-35. PubMed ID: 24628236
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells.
    Papa V; Tazzari PL; Chiarini F; Cappellini A; Ricci F; Billi AM; Evangelisti C; Ottaviani E; Martinelli G; Testoni N; McCubrey JA; Martelli AM
    Leukemia; 2008 Jan; 22(1):147-60. PubMed ID: 17928881
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Basic fibroblast growth factor modulates the aminophospholipid translocase activity present in the plasma membrane of bovine aortic endothelial cells.
    Julien M; Tournier JF; Tocanne JF
    Eur J Biochem; 1995 May; 230(1):287-97. PubMed ID: 7601112
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Protein-mediated inward translocation of phospholipids occurs in both the apical and basolateral plasma membrane domains of epithelial cells.
    Pomorski T; Herrmann A; Müller P; van Meer G; Burger K
    Biochemistry; 1999 Jan; 38(1):142-50. PubMed ID: 9890892
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition.
    Burgeiro A; Pereira CV; Carvalho FS; Pereira GC; Mollinedo F; Oliveira PJ
    Mitochondrion; 2013 Jan; 13(1):25-35. PubMed ID: 23164800
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.