154 related articles for article (PubMed ID: 18024134)
1. Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.
Grunewald GL; Seim MR; Bhat SR; Wilson ME; Criscione KR
Bioorg Med Chem; 2008 Jan; 16(1):542-59. PubMed ID: 18024134
[TBL] [Abstract][Full Text] [Related]
2. Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
Grunewald GL; Seim MR; Regier RC; Martin JL; Gee CL; Drinkwater N; Criscione KR
J Med Chem; 2006 Sep; 49(18):5424-33. PubMed ID: 16942016
[TBL] [Abstract][Full Text] [Related]
3. Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.
Grunewald GL; Seim MR; Regier RC; Criscione KR
Bioorg Med Chem; 2007 Feb; 15(3):1298-310. PubMed ID: 17126018
[TBL] [Abstract][Full Text] [Related]
4. Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination.
Grunewald GL; Seim MR; Lu J; Makboul M; Criscione KR
J Med Chem; 2006 May; 49(10):2939-52. PubMed ID: 16686536
[TBL] [Abstract][Full Text] [Related]
5. 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.
Grunewald GL; Dahanukar VH; Teoh B; Criscione KR
J Med Chem; 1999 Jun; 42(11):1982-90. PubMed ID: 10354406
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Grunewald GL; Caldwell TM; Li Q; Criscione KR
J Med Chem; 1999 Aug; 42(17):3315-23. PubMed ID: 10464018
[TBL] [Abstract][Full Text] [Related]
7. Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and alpha2-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines.
Grunewald GL; Dahanukar VH; Criscione KR
Bioorg Med Chem; 2001 Aug; 9(8):1957-65. PubMed ID: 11504632
[TBL] [Abstract][Full Text] [Related]
8. Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Grunewald GL; Caldwell TM; Li Q; Dahanukar VH; McNeil B; Criscione KR
J Med Chem; 1999 Oct; 42(21):4351-61. PubMed ID: 10543879
[TBL] [Abstract][Full Text] [Related]
9. 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity.
Grunewald GL; Romero FA; Criscione KR
J Med Chem; 2005 Jan; 48(1):134-40. PubMed ID: 15634007
[TBL] [Abstract][Full Text] [Related]
10. Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity.
Grunewald GL; Lu J; Criscione KR; Okoro CO
Bioorg Med Chem Lett; 2005 Dec; 15(23):5319-23. PubMed ID: 16169723
[TBL] [Abstract][Full Text] [Related]
11. Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor.
Romero FA; Vodonick SM; Criscione KR; McLeish MJ; Grunewald GL
J Med Chem; 2004 Aug; 47(18):4483-93. PubMed ID: 15317460
[TBL] [Abstract][Full Text] [Related]
12. Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
Grunewald GL; Romero FA; Seim MR; Criscione KR; Deupree JD; Spackman CC; Bylund DB
Bioorg Med Chem Lett; 2005 Feb; 15(4):1143-7. PubMed ID: 15686930
[TBL] [Abstract][Full Text] [Related]
13. Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha2-adrenoceptor.
Grunewald GL; Dahanukar VH; Jalluri RK; Criscione KR
J Med Chem; 1999 Jan; 42(1):118-34. PubMed ID: 9888838
[TBL] [Abstract][Full Text] [Related]
14. Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.
Grunewald GL; Sall DJ; Monn JA
J Med Chem; 1988 Feb; 31(2):433-44. PubMed ID: 3339613
[TBL] [Abstract][Full Text] [Related]
15. Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.
Wu Q; Gee CL; Lin F; Tyndall JD; Martin JL; Grunewald GL; McLeish MJ
J Med Chem; 2005 Nov; 48(23):7243-52. PubMed ID: 16279783
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.
Grunewald GL; Sall DJ; Monn JA
J Med Chem; 1988 Apr; 31(4):824-30. PubMed ID: 3351861
[TBL] [Abstract][Full Text] [Related]
17. 1,3-Dimethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as probes for the binding orientation of tetrahydroisoquinoline at the active site of phenylethanolamine N-methyltransferase.
Grunewald GL; Caldwell TM; Li Q; Criscione KR
Bioorg Med Chem; 1999 May; 7(5):869-80. PubMed ID: 10400340
[TBL] [Abstract][Full Text] [Related]
18. Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.
Grunewald GL; Caldwell TM; Dahanukar VH; Jalluri RK; Criscione KR
Bioorg Med Chem Lett; 1999 Feb; 9(3):481-6. PubMed ID: 10091706
[TBL] [Abstract][Full Text] [Related]
19. Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.
Grunewald GL; Dahanukar VH; Caldwell TM; Criscione KR
J Med Chem; 1997 Dec; 40(25):3997-4005. PubMed ID: 9406590
[TBL] [Abstract][Full Text] [Related]
20. Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine
Lu J; Bart AG; Wu Q; Criscione KR; McLeish MJ; Scott EE; Grunewald GL
J Med Chem; 2020 Nov; 63(22):13878-13898. PubMed ID: 33147410
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
