106 related articles for article (PubMed ID: 18024786)
1. Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis.
Bedard PW; Clerin V; Sushkova N; Tchernychev B; Antrilli T; Resmini C; Keith JC; Hennan JK; Kaila N; Debernardo S; Janz K; Wang Q; Crandall DL; Schaub RG; Shaw GD; Carter LL
J Pharmacol Exp Ther; 2008 Feb; 324(2):497-506. PubMed ID: 18024786
[TBL] [Abstract][Full Text] [Related]
2. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis.
Myers DD; Henke PK; Bedard PW; Wrobleski SK; Kaila N; Shaw G; Meier TR; Hawley AE; Schaub RG; Wakefield TW
J Vasc Surg; 2006 Sep; 44(3):625-32. PubMed ID: 16950445
[TBL] [Abstract][Full Text] [Related]
3. 2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.
Kaila N; Janz K; Huang A; Moretto A; DeBernardo S; Bedard PW; Tam S; Clerin V; Keith JC; Tsao DH; Sushkova N; Shaw GD; Camphausen RT; Schaub RG; Wang Q
J Med Chem; 2007 Jan; 50(1):40-64. PubMed ID: 17201409
[TBL] [Abstract][Full Text] [Related]
4. Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Huang A; Moretto A; Janz K; Lowe M; Bedard PW; Tam S; Di L; Clerin V; Sushkova N; Tchernychev B; Tsao DH; Keith JC; Shaw GD; Schaub RG; Wang Q; Kaila N
J Med Chem; 2010 Aug; 53(16):6003-17. PubMed ID: 20718494
[TBL] [Abstract][Full Text] [Related]
5. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation.
Myers DD; Wrobleski SK; Longo C; Bedard PW; Kaila N; Shaw GD; Londy FJ; Rohrer SE; Fex BA; Zajkowski PJ; Meier TR; Hawley AE; Farris DM; Ballard NE; Henke PK; Schaub RG; Wakefield TW
Thromb Haemost; 2007 Mar; 97(3):400-7. PubMed ID: 17334507
[TBL] [Abstract][Full Text] [Related]
6. Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation.
Meier TR; Myers DD; Wrobleski SK; Zajkowski PJ; Hawley AE; Bedard PW; Ballard NE; Londy FJ; Kaila N; Vlasuk GP; Schaub RG; Wakefield TW
Thromb Haemost; 2008 Feb; 99(2):343-51. PubMed ID: 18278184
[TBL] [Abstract][Full Text] [Related]
7. Decreased venous thrombosis with an oral inhibitor of P selectin.
Myers DD; Rectenwald JE; Bedard PW; Kaila N; Shaw GD; Schaub RG; Farris DM; Hawley AE; Wrobleski SK; Henke PK; Wakefield TW
J Vasc Surg; 2005 Aug; 42(2):329-36. PubMed ID: 16102635
[TBL] [Abstract][Full Text] [Related]
8. Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models.
Feng Q; Wang M; Muhtar E; Wang Y; Zhu H
Int J Nanomedicine; 2021; 16():5777-5795. PubMed ID: 34471352
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.
Kaila N; Janz K; DeBernardo S; Bedard PW; Camphausen RT; Tam S; Tsao DH; Keith JC; Nickerson-Nutter C; Shilling A; Young-Sciame R; Wang Q
J Med Chem; 2007 Jan; 50(1):21-39. PubMed ID: 17201408
[TBL] [Abstract][Full Text] [Related]
10. P-selectin antagonism reduces thrombus formation in humans.
Chelliah R; Lucking AJ; Tattersall L; Daga S; Beresford-Cleary NJ; Cortas K; Fox KA; Feuerstein GZ; Connolly TM; Newby DE
J Thromb Haemost; 2009 Nov; 7(11):1915-9. PubMed ID: 19691482
[TBL] [Abstract][Full Text] [Related]
11. Soluble P-selectin antagonist mediates rolling velocity and adhesion of leukocytes in acutely inflamed venules.
Eppihimer MJ; Schaub RG
Microcirculation; 2001 Feb; 8(1):15-24. PubMed ID: 11296849
[TBL] [Abstract][Full Text] [Related]
12. A new way to treat proximal deep venous thrombosis using E-selectin inhibition.
Myers D; Lester P; Adili R; Hawley A; Durham L; Dunivant V; Reynolds G; Crego K; Zimmerman Z; Sood S; Sigler R; Fogler W; Magnani J; Holinstat M; Wakefield T
J Vasc Surg Venous Lymphat Disord; 2020 Mar; 8(2):268-278. PubMed ID: 32067728
[TBL] [Abstract][Full Text] [Related]
13. E-selectin inhibition with GMI-1271 decreases venous thrombosis without profoundly affecting tail vein bleeding in a mouse model.
Culmer DL; Dunbar ML; Hawley AE; Sood S; Sigler RE; Henke PK; Wakefield TW; Magnani JL; Myers DD
Thromb Haemost; 2017 Jun; 117(6):1171-1181. PubMed ID: 28300869
[TBL] [Abstract][Full Text] [Related]
14. P-selectin inhibition therapeutically promotes thrombus resolution and prevents vein wall fibrosis better than enoxaparin and an inhibitor to von Willebrand factor.
Diaz JA; Wrobleski SK; Alvarado CM; Hawley AE; Doornbos NK; Lester PA; Lowe SE; Gabriel JE; Roelofs KJ; Henke PK; Schaub RG; Wakefield TW; Myers DD
Arterioscler Thromb Vasc Biol; 2015 Apr; 35(4):829-37. PubMed ID: 25657307
[TBL] [Abstract][Full Text] [Related]
15. Novel microspheres reduce the formation of deep venous thrombosis and repair the vascular wall in a rat model.
Dai B; Li L; Li Q; Song X; Chen D; Dai J; Yao Y; Yan W; Teng H; Yang F; Xu Z; Jiang Q
Blood Coagul Fibrinolysis; 2017 Jul; 28(5):398-406. PubMed ID: 28306627
[TBL] [Abstract][Full Text] [Related]
16. The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor, in rat models of venous and arterial thrombosis.
Cho JH; Yun CH; Seo HS; Koga T; Dan T; Koo BA; Kim HY
Thromb Haemost; 2001 Dec; 86(6):1512-20. PubMed ID: 11776321
[TBL] [Abstract][Full Text] [Related]
17. Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression.
Jin H; Gebska MA; Blokhin IO; Wilson KM; Ketsawatsomkron P; Chauhan AK; Keen HL; Sigmund CD; Lentz SR
Arterioscler Thromb Vasc Biol; 2015 Apr; 35(4):838-44. PubMed ID: 25675995
[TBL] [Abstract][Full Text] [Related]
18. E-selectin blockade decreases adventitial inflammation and attenuates intimal hyperplasia in rat carotid arteries after balloon injury.
Gotoh R; Suzuki J; Kosuge H; Kakuta T; Sakamoto S; Yoshida M; Isobe M
Arterioscler Thromb Vasc Biol; 2004 Nov; 24(11):2063-8. PubMed ID: 15388522
[TBL] [Abstract][Full Text] [Related]
19. No detectable endothelial- or leukocyte-derived L-selectin ligand activity on the endothelium in inflamed cremaster muscle venules.
Eriksson EE
J Leukoc Biol; 2008 Jul; 84(1):93-103. PubMed ID: 18381812
[TBL] [Abstract][Full Text] [Related]
20. Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression.
Lindenblatt N; Schareck W; Belusa L; Nickels RM; Menger MD; Vollmar B
Thromb Haemost; 2003 Nov; 90(5):882-92. PubMed ID: 14597984
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]