BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

444 related articles for article (PubMed ID: 18030348)

  • 1. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.
    Thedieck K; Polak P; Kim ML; Molle KD; Cohen A; Jenö P; Arrieumerlou C; Hall MN
    PLoS One; 2007 Nov; 2(11):e1217. PubMed ID: 18030348
    [TBL] [Abstract][Full Text] [Related]  

  • 2. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
    Woo SY; Kim DH; Jun CB; Kim YM; Haar EV; Lee SI; Hegg JW; Bandhakavi S; Griffin TJ; Kim DH
    J Biol Chem; 2007 Aug; 282(35):25604-12. PubMed ID: 17599906
    [TBL] [Abstract][Full Text] [Related]  

  • 3. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
    Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
    Oshiro N; Takahashi R; Yoshino K; Tanimura K; Nakashima A; Eguchi S; Miyamoto T; Hara K; Takehana K; Avruch J; Kikkawa U; Yonezawa K
    J Biol Chem; 2007 Jul; 282(28):20329-39. PubMed ID: 17517883
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
    Wang L; Harris TE; Roth RA; Lawrence JC
    J Biol Chem; 2007 Jul; 282(27):20036-44. PubMed ID: 17510057
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction.
    Hong-Brown LQ; Brown CR; Kazi AA; Huber DS; Pruznak AM; Lang CH
    J Cell Biochem; 2010 Apr; 109(6):1172-84. PubMed ID: 20127721
    [TBL] [Abstract][Full Text] [Related]  

  • 7. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.
    Fonseca BD; Smith EM; Lee VH; MacKintosh C; Proud CG
    J Biol Chem; 2007 Aug; 282(34):24514-24. PubMed ID: 17604271
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK; Pizzo SV
    PLoS One; 2012; 7(12):e51735. PubMed ID: 23272152
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.
    Rapley J; Oshiro N; Ortiz-Vega S; Avruch J
    J Biol Chem; 2011 Nov; 286(44):38043-38053. PubMed ID: 21914810
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.
    Wang L; Harris TE; Lawrence JC
    J Biol Chem; 2008 Jun; 283(23):15619-27. PubMed ID: 18372248
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.
    Zhang L; Kimball SR; Jefferson LS; Shenberger JS
    Free Radic Biol Med; 2009 Jun; 46(11):1500-9. PubMed ID: 19281842
    [TBL] [Abstract][Full Text] [Related]  

  • 12. MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress.
    Ozturk DG; Kocak M; Akcay A; Kinoglu K; Kara E; Buyuk Y; Kazan H; Gozuacik D
    Autophagy; 2019 Mar; 15(3):375-390. PubMed ID: 30290719
    [TBL] [Abstract][Full Text] [Related]  

  • 13. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
    Sancak Y; Thoreen CC; Peterson TR; Lindquist RA; Kang SA; Spooner E; Carr SA; Sabatini DM
    Mol Cell; 2007 Mar; 25(6):903-15. PubMed ID: 17386266
    [TBL] [Abstract][Full Text] [Related]  

  • 14. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.
    Xie J; Ponuwei GA; Moore CE; Willars GB; Tee AR; Herbert TP
    Cell Signal; 2011 Dec; 23(12):1927-35. PubMed ID: 21763421
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
    Vander Haar E; Lee SI; Bandhakavi S; Griffin TJ; Kim DH
    Nat Cell Biol; 2007 Mar; 9(3):316-23. PubMed ID: 17277771
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of PRAS40 in Akt and mTOR signaling in health and disease.
    Wiza C; Nascimento EB; Ouwens DM
    Am J Physiol Endocrinol Metab; 2012 Jun; 302(12):E1453-60. PubMed ID: 22354785
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
    Sato T; Nakashima A; Guo L; Tamanoi F
    J Biol Chem; 2009 May; 284(19):12783-91. PubMed ID: 19299511
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.
    Völkers M; Konstandin MH; Doroudgar S; Toko H; Quijada P; Din S; Joyo A; Ornelas L; Samse K; Thuerauf DJ; Gude N; Glembotski CC; Sussman MA
    Circulation; 2013 Nov; 128(19):2132-44. PubMed ID: 24008870
    [TBL] [Abstract][Full Text] [Related]  

  • 19. AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis.
    Mi W; Ye Q; Liu S; She QB
    Oncotarget; 2015 Jun; 6(16):13962-77. PubMed ID: 25961827
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.
    Toschi A; Lee E; Xu L; Garcia A; Gadir N; Foster DA
    Mol Cell Biol; 2009 Mar; 29(6):1411-20. PubMed ID: 19114562
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.