291 related articles for article (PubMed ID: 18032377)
1. Identification of gamma-secretase inhibitor potency determinants on presenilin.
Zhao B; Yu M; Neitzel M; Marugg J; Jagodzinski J; Lee M; Hu K; Schenk D; Yednock T; Basi G
J Biol Chem; 2008 Feb; 283(5):2927-38. PubMed ID: 18032377
[TBL] [Abstract][Full Text] [Related]
2. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
[TBL] [Abstract][Full Text] [Related]
3. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.
Czirr E; Leuchtenberger S; Dorner-Ciossek C; Schneider A; Jucker M; Koo EH; Pietrzik CU; Baumann K; Weggen S
J Biol Chem; 2007 Aug; 282(34):24504-13. PubMed ID: 17573346
[TBL] [Abstract][Full Text] [Related]
4. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
[TBL] [Abstract][Full Text] [Related]
5. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
Page RM; Baumann K; Tomioka M; Pérez-Revuelta BI; Fukumori A; Jacobsen H; Flohr A; Luebbers T; Ozmen L; Steiner H; Haass C
J Biol Chem; 2008 Jan; 283(2):677-83. PubMed ID: 17962197
[TBL] [Abstract][Full Text] [Related]
6. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.
Marinangeli C; Tasiaux B; Opsomer R; Hage S; Sodero AO; Dewachter I; Octave JN; Smith SO; Constantinescu SN; Kienlen-Campard P
J Biol Chem; 2015 Mar; 290(11):7169-84. PubMed ID: 25614624
[TBL] [Abstract][Full Text] [Related]
7. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
[TBL] [Abstract][Full Text] [Related]
8. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
Lammich S; Okochi M; Takeda M; Kaether C; Capell A; Zimmer AK; Edbauer D; Walter J; Steiner H; Haass C
J Biol Chem; 2002 Nov; 277(47):44754-9. PubMed ID: 12223485
[TBL] [Abstract][Full Text] [Related]
9. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
Pintchovski SA; Schenk DB; Basi GS
Curr Alzheimer Res; 2013 Jan; 10(1):4-10. PubMed ID: 22950863
[TBL] [Abstract][Full Text] [Related]
10. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
Fukumori A; Fluhrer R; Steiner H; Haass C
J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
[TBL] [Abstract][Full Text] [Related]
11. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
[TBL] [Abstract][Full Text] [Related]
12. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
[TBL] [Abstract][Full Text] [Related]
13. Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.
Borgegård T; Gustavsson S; Nilsson C; Parpal S; Klintenberg R; Berg AL; Rosqvist S; Serneels L; Svensson S; Olsson F; Jin S; Yan H; Wanngren J; Jureus A; Ridderstad-Wollberg A; Wollberg P; Stockling K; Karlström H; Malmberg A; Lund J; Arvidsson PI; De Strooper B; Lendahl U; Lundkvist J
J Neurosci; 2012 Nov; 32(48):17297-305. PubMed ID: 23197721
[TBL] [Abstract][Full Text] [Related]
14. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
15. Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase.
Eccles MK; Main N; Carlessi R; Armstrong AM; Sabale M; Roberts-Mok B; Tirnitz-Parker JEE; Agostino M; Groth D; Fraser PE; Verdile G
FASEB J; 2024 Jan; 38(1):e23396. PubMed ID: 38156414
[TBL] [Abstract][Full Text] [Related]
16. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
[TBL] [Abstract][Full Text] [Related]
17. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Heilig EA; Xia W; Shen J; Kelleher RJ
J Biol Chem; 2010 Jul; 285(29):22350-9. PubMed ID: 20460383
[TBL] [Abstract][Full Text] [Related]
18. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
[TBL] [Abstract][Full Text] [Related]
19. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
[TBL] [Abstract][Full Text] [Related]
20. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
Islam S; Sun Y; Gao Y; Nakamura T; Noorani AA; Li T; Wong PC; Kimura N; Matsubara E; Kasuga K; Ikeuchi T; Tomita T; Zou K; Michikawa M
J Neurosci; 2022 Feb; 42(8):1574-1586. PubMed ID: 34987110
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
