183 related articles for article (PubMed ID: 18032380)
1. Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change.
Li YC; Chiang CW; Yeh HC; Hsu PY; Whitby FG; Wang LH; Chan NL
J Biol Chem; 2008 Feb; 283(5):2917-26. PubMed ID: 18032380
[TBL] [Abstract][Full Text] [Related]
2. Probing the interaction between prostacyclin synthase and prostaglandin H2 analogues or inhibitors via a combination of resonance Raman spectroscopy and molecular dynamics simulation approaches.
Chao WC; Lu JF; Wang JS; Yang HC; Chen HH; Lan YK; Yu YC; Chou PT; Wang LH
J Am Chem Soc; 2011 Nov; 133(46):18870-9. PubMed ID: 21978190
[TBL] [Abstract][Full Text] [Related]
3. Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase.
Yeh HC; Hsu PY; Wang JS; Tsai AL; Wang LH
Biochim Biophys Acta; 2005 Dec; 1738(1-3):121-32. PubMed ID: 16406803
[TBL] [Abstract][Full Text] [Related]
4. Crystal structure of the human prostacyclin synthase.
Chiang CW; Yeh HC; Wang LH; Chan NL
J Mol Biol; 2006 Dec; 364(3):266-74. PubMed ID: 17020766
[TBL] [Abstract][Full Text] [Related]
5. Topology of catalytic portion of prostaglandin I(2) synthase: identification by molecular modeling-guided site-specific antibodies.
Lin YZ; Deng H; Ruan KH
Arch Biochem Biophys; 2000 Jul; 379(2):188-97. PubMed ID: 10898934
[TBL] [Abstract][Full Text] [Related]
6. Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin.
Ruan KH; Wu J; Cervantes V
Biochemistry; 2008 Jan; 47(2):680-8. PubMed ID: 18081314
[TBL] [Abstract][Full Text] [Related]
7. Identification of the residues in the helix F/G loop important to catalytic function of membrane-bound prostacyclin synthase.
Deng H; Wu J; So SP; Ruan KH
Biochemistry; 2003 May; 42(19):5609-17. PubMed ID: 12741817
[TBL] [Abstract][Full Text] [Related]
8. Cellular and molecular biology of prostacyclin synthase.
Wu KK; Liou JY
Biochem Biophys Res Commun; 2005 Dec; 338(1):45-52. PubMed ID: 16115610
[TBL] [Abstract][Full Text] [Related]
9. Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase.
Li L; Chang Z; Pan Z; Fu ZQ; Wang X
Proc Natl Acad Sci U S A; 2008 Sep; 105(37):13883-8. PubMed ID: 18787124
[TBL] [Abstract][Full Text] [Related]
10. Purification and characterization of recombinant human prostacyclin synthase.
Wada M; Yokoyama C; Hatae T; Shimonishi M; Nakamura M; Imai Y; Ullrich V; Tanabe T
J Biochem; 2004 Apr; 135(4):455-63. PubMed ID: 15115769
[TBL] [Abstract][Full Text] [Related]
11. Characterization of the secondary structure and membrane interaction of the putative membrane anchor domains of prostaglandin I2 synthase and cytochrome P450 2C1.
Lin Y; Wu KK; Ruan KH
Arch Biochem Biophys; 1998 Apr; 352(1):78-84. PubMed ID: 9521818
[TBL] [Abstract][Full Text] [Related]
12. Molecular cloning and characterization of bovine prostacyclin synthase.
Pereira B; Wu KK; Wang LH
Biochem Biophys Res Commun; 1994 Aug; 203(1):59-66. PubMed ID: 8074709
[TBL] [Abstract][Full Text] [Related]
13. Substrate access channel topology in membrane-bound prostacyclin synthase.
Deng H; Huang A; So SP; Lin YZ; Ruan KH
Biochem J; 2002 Mar; 362(Pt 3):545-51. PubMed ID: 11879180
[TBL] [Abstract][Full Text] [Related]
14. The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase.
Ruan KH; Deng H; Wu J; So SP
Arch Biochem Biophys; 2005 Mar; 435(2):372-81. PubMed ID: 15708381
[TBL] [Abstract][Full Text] [Related]
15. Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate.
Yeh HC; Gerfen GJ; Wang JS; Tsai AL; Wang LH
Biochemistry; 2009 Feb; 48(5):917-28. PubMed ID: 19187034
[TBL] [Abstract][Full Text] [Related]
16. Prostacyclin synthase active sites. Identification by molecular modeling-guided site-directed mutagenesis.
Shyue SK; Ruan KH; Wang LH; Wu KK
J Biol Chem; 1997 Feb; 272(6):3657-62. PubMed ID: 9013619
[TBL] [Abstract][Full Text] [Related]
17. Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2.
Akasaka H; So SP; Ruan KH
Biochemistry; 2015 Jun; 54(23):3707-15. PubMed ID: 25988363
[TBL] [Abstract][Full Text] [Related]
18. Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin.
Ruan KH; Deng H; So SP
Biochemistry; 2006 Nov; 45(47):14003-11. PubMed ID: 17115695
[TBL] [Abstract][Full Text] [Related]
19. A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding.
Modi S; Paine MJ; Sutcliffe MJ; Lian LY; Primrose WU; Wolf CR; Roberts GC
Biochemistry; 1996 Apr; 35(14):4540-50. PubMed ID: 8605204
[TBL] [Abstract][Full Text] [Related]
20. Theoretical study of the ligand-CYP2B4 complexes: effect of structure on binding free energies and heme spin state.
Harris DL; Park JY; Gruenke L; Waskell L
Proteins; 2004 Jun; 55(4):895-914. PubMed ID: 15146488
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
