These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 18033714)

  • 1. Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis.
    Crane CM; Hirsch AK; Alphey MS; Sgraja T; Lauw S; Illarionova V; Rohdich F; Eisenreich W; Hunter WN; Bacher A; Diederich F
    ChemMedChem; 2008 Jan; 3(1):91-101. PubMed ID: 18033714
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.
    Hirsch AK; Lauw S; Gersbach P; Schweizer WB; Rohdich F; Eisenreich W; Bacher A; Diederich F
    ChemMedChem; 2007 Jun; 2(6):806-10. PubMed ID: 17361977
    [No Abstract]   [Full Text] [Related]  

  • 3. Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis.
    Hirsch AK; Alphey MS; Lauw S; Seet M; Barandun L; Eisenreich W; Rohdich F; Hunter WN; Bacher A; Diederich F
    Org Biomol Chem; 2008 Aug; 6(15):2719-30. PubMed ID: 18633530
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis.
    Shan S; Chen X; Liu T; Zhao H; Rao Z; Lou Z
    FASEB J; 2011 May; 25(5):1577-84. PubMed ID: 21282208
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.
    Crane CM; Kaiser J; Ramsden NL; Lauw S; Rohdich F; Eisenreich W; Hunter WN; Bacher A; Diederich F
    Angew Chem Int Ed Engl; 2006 Feb; 45(7):1069-74. PubMed ID: 16392111
    [No Abstract]   [Full Text] [Related]  

  • 6. Crystal structure of the bifunctional ATP sulfurylase-APS kinase from the chemolithotrophic thermophile Aquifex aeolicus.
    Yu Z; Lansdon EB; Segel IH; Fisher AJ
    J Mol Biol; 2007 Jan; 365(3):732-43. PubMed ID: 17095009
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.
    Richard SB; Bowman ME; Kwiatkowski W; Kang I; Chow C; Lillo AM; Cane DE; Noel JP
    Nat Struct Biol; 2001 Jul; 8(7):641-8. PubMed ID: 11427897
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.
    Lu H; Tonge PJ
    Acc Chem Res; 2008 Jan; 41(1):11-20. PubMed ID: 18193820
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods.
    Illarionova V; Kaiser J; Ostrozhenkova E; Bacher A; Fischer M; Eisenreich W; Rohdich F
    J Org Chem; 2006 Nov; 71(23):8824-34. PubMed ID: 17081012
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.
    Steinbacher S; Kaiser J; Wungsintaweekul J; Hecht S; Eisenreich W; Gerhardt S; Bacher A; Rohdich F
    J Mol Biol; 2002 Feb; 316(1):79-88. PubMed ID: 11829504
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target.
    Andreassi JL; Dabovic K; Leyh TS
    Biochemistry; 2004 Dec; 43(51):16461-6. PubMed ID: 15610040
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characteristics of the Plasmodium falciparum PK5 ATP-binding site: implications for the design of novel antimalarial agents.
    Keenan SM; Welsh WJ
    J Mol Graph Model; 2004 Jan; 22(3):241-7. PubMed ID: 14629982
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based drug design: exploring the proper filling of apolar pockets at enzyme active sites.
    Zürcher M; Diederich F
    J Org Chem; 2008 Jun; 73(12):4345-61. PubMed ID: 18510366
    [TBL] [Abstract][Full Text] [Related]  

  • 14. (R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode.
    Mueller MM; Sperl S; Stürzebecher J; Bode W; Moroder L
    Biol Chem; 2002; 383(7-8):1185-91. PubMed ID: 12437104
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Invariance and variability in bacterial PanK: a study based on the crystal structure of Mycobacterium tuberculosis PanK.
    Das S; Kumar P; Bhor V; Surolia A; Vijayan M
    Acta Crystallogr D Biol Crystallogr; 2006 Jun; 62(Pt 6):628-38. PubMed ID: 16699190
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods.
    Kemp LE; Alphey MS; Bond CS; Ferguson MA; Hecht S; Bacher A; Eisenreich W; Rohdich F; Hunter WN
    Acta Crystallogr D Biol Crystallogr; 2005 Jan; 61(Pt 1):45-52. PubMed ID: 15608374
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site.
    Gayathri P; Banerjee M; Vijayalakshmi A; Balaram H; Balaram P; Murthy MR
    Acta Crystallogr D Biol Crystallogr; 2009 Aug; 65(Pt 8):847-57. PubMed ID: 19622869
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Plasmepsin inhibitors: design, synthesis, inhibitory studies and crystal structure analysis.
    Kesavulu MM; Prakasha Gowda AS; Ramya TN; Surolia N; Suguna K
    J Pept Res; 2005 Oct; 66(4):211-9. PubMed ID: 16138859
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, and evaluation of gamma-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of gamma-glutamyl transpeptidase.
    Han L; Hiratake J; Kamiyama A; Sakata K
    Biochemistry; 2007 Feb; 46(5):1432-47. PubMed ID: 17260973
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid.
    Pereira JH; de Oliveira JS; Canduri F; Dias MV; Palma MS; Basso LA; Santos DS; de Azevedo WF
    Acta Crystallogr D Biol Crystallogr; 2004 Dec; 60(Pt 12 Pt 2):2310-9. PubMed ID: 15583379
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.