BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

259 related articles for article (PubMed ID: 18038968)

  • 1. (S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.
    Bell MG; Gernert DL; Grese TA; Belvo MD; Borromeo PS; Kelley SA; Kennedy JH; Kolis SP; Lander PA; Richey R; Sharp VS; Stephenson GA; Williams JD; Yu H; Zimmerman KM; Steinberg MI; Jadhav PK
    J Med Chem; 2007 Dec; 50(26):6443-5. PubMed ID: 18038968
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists.
    Arhancet GB; Woodard SS; Iyanar K; Case BL; Woerndle R; Dietz JD; Garland DJ; Collins JT; Payne MA; Blinn JR; Pomposiello SI; Hu X; Heron MI; Huang HC; Lee LF
    J Med Chem; 2010 Aug; 53(16):5970-8. PubMed ID: 20672820
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptor antagonists.
    Hategan G; Polozov AM; Zeller W; Cao H; Mishra RK; Kiselyov AS; Ramirez J; Halldorsdottir G; Andrésson T; Gurney ME; Singh J
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6797-800. PubMed ID: 19836233
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.
    Hasui T; Matsunaga N; Ora T; Ohyabu N; Nishigaki N; Imura Y; Igata Y; Matsui H; Motoyaji T; Tanaka T; Habuka N; Sogabe S; Ono M; Siedem CS; Tang TP; Gauthier C; De Meese LA; Boyd SA; Fukumoto S
    J Med Chem; 2011 Dec; 54(24):8616-31. PubMed ID: 22074142
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.
    Cole DC; Lennox WJ; Lombardi S; Ellingboe JW; Bernotas RC; Tawa GJ; Mazandarani H; Smith DL; Zhang G; Coupet J; Schechter LE
    J Med Chem; 2005 Jan; 48(2):353-6. PubMed ID: 15658848
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design.
    Raboisson P; Desjarlais RL; Reed R; Lattanze J; Chaikin M; Manthey CL; Tomczuk BE; Marugán JJ
    Eur J Med Chem; 2007 Mar; 42(3):334-43. PubMed ID: 17184884
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent.
    Shetty RS; Lee Y; Liu B; Husain A; Joseph RW; Lu Y; Nelson D; Mihelcic J; Chao W; Moffett KK; Schumacher A; Flubacher D; Stojanovic A; Bukhtiyarova M; Williams K; Lee KJ; Ochman AR; Saporito MS; Moore WR; Flynn GA; Dorsey BD; Springman EB; Fujimoto T; Kelly MJ
    J Med Chem; 2011 Jan; 54(1):179-200. PubMed ID: 21126027
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and antihypertensive activity evaluation of indole derivatives N-acetamido substituted.
    Grasso S; Molica C; Monforte AM; Monforte P; Zappalà M; Monforte MT; Trovato A
    Farmaco; 1995 Feb; 50(2):113-7. PubMed ID: 7766275
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.
    Hasui T; Ohyabu N; Ohra T; Fuji K; Sugimoto T; Fujimoto J; Asano K; Oosawa M; Shiotani S; Nishigaki N; Kusumoto K; Matsui H; Mizukami A; Habuka N; Sogabe S; Endo S; Ono M; Siedem CS; Tang TP; Gauthier C; De Meese LA; Boyd SA; Fukumoto S
    Bioorg Med Chem; 2014 Oct; 22(19):5428-45. PubMed ID: 25187277
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.
    Casimiro-Garcia A; Filzen GF; Flynn D; Bigge CF; Chen J; Davis JA; Dudley DA; Edmunds JJ; Esmaeil N; Geyer A; Heemstra RJ; Jalaie M; Ohren JF; Ostroski R; Ellis T; Schaum RP; Stoner C
    J Med Chem; 2011 Jun; 54(12):4219-33. PubMed ID: 21557540
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.
    Frost JM; Dart MJ; Tietje KR; Garrison TR; Grayson GK; Daza AV; El-Kouhen OF; Miller LN; Li L; Yao BB; Hsieh GC; Pai M; Zhu CZ; Chandran P; Meyer MD
    J Med Chem; 2008 Mar; 51(6):1904-12. PubMed ID: 18311894
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors.
    Terasaka T; Kinoshita T; Kuno M; Seki N; Tanaka K; Nakanishi I
    J Med Chem; 2004 Jul; 47(15):3730-43. PubMed ID: 15239652
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.
    Baron BM; Cregge RJ; Farr RA; Friedrich D; Gross RS; Harrison BL; Janowick DA; Matthews D; McCloskey TC; Meikrantz S; Nyce PL; Vaz R; Metz WA
    J Med Chem; 2005 Feb; 48(4):995-1018. PubMed ID: 15715469
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
    May JA; Chen HH; Rusinko A; Lynch VM; Sharif NA; McLaughlin MA
    J Med Chem; 2003 Sep; 46(19):4188-95. PubMed ID: 12954071
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 1-[(Imidazolidin-2-yl)imino]indazole. Highly alpha 2/I1 selective agonist: synthesis, X-ray structure, and biological activity.
    Saczewski F; Kornicka A; Rybczyńska A; Hudson AL; Miao SS; Gdaniec M; Boblewski K; Lehmann A
    J Med Chem; 2008 Jun; 51(12):3599-608. PubMed ID: 18517187
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of N-(4'-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication.
    Chen G; Ren H; Turpoff A; Arefolov A; Wilde R; Takasugi J; Khan A; Almstead N; Gu Z; Komatsu T; Freund C; Breslin J; Colacino J; Hedrick J; Weetall M; Karp GM
    Bioorg Med Chem Lett; 2013 Jul; 23(13):3942-6. PubMed ID: 23683596
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The discovery of a potent orally efficacious indole androgen receptor antagonist through in vivo screening.
    Lanter JC; Fiordeliso JJ; Jiang W; Allan GF; Lai MT; Linton O; Hahn do W; Lundeen SG; Sui Z
    Bioorg Med Chem Lett; 2007 Jan; 17(1):123-6. PubMed ID: 17071085
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator.
    Ward SE; Harries M; Aldegheri L; Andreotti D; Ballantine S; Bax BD; Harris AJ; Harker AJ; Lund J; Melarange R; Mingardi A; Mookherjee C; Mosley J; Neve M; Oliosi B; Profeta R; Smith KJ; Smith PW; Spada S; Thewlis KM; Yusaf SP
    J Med Chem; 2010 Aug; 53(15):5801-12. PubMed ID: 20614889
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and alpha-adrenolytic activity.
    Kulig K; Sapa J; Nowaczyk A; Filipek B; Malawska B
    Eur J Med Chem; 2009 Oct; 44(10):3994-4003. PubMed ID: 19447527
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 2-(2,3-Dihydro-1H-indol-3-yl)ethanol: synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis.
    Frydenvang K; Sommer MB; Heckmann D; Nielsen O; Bang-Andersen B
    Chirality; 2004 Feb; 16(2):126-30. PubMed ID: 14712476
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.