161 related articles for article (PubMed ID: 18056281)
1. Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.
Ray AS; Vela JE; Boojamra CG; Zhang L; Hui H; Callebaut C; Stray K; Lin KY; Gao Y; Mackman RL; Cihlar T
Antimicrob Agents Chemother; 2008 Feb; 52(2):648-54. PubMed ID: 18056281
[TBL] [Abstract][Full Text] [Related]
2. Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
Cihlar T; Ray AS; Boojamra CG; Zhang L; Hui H; Laflamme G; Vela JE; Grant D; Chen J; Myrick F; White KL; Gao Y; Lin KY; Douglas JL; Parkin NT; Carey A; Pakdaman R; Mackman RL
Antimicrob Agents Chemother; 2008 Feb; 52(2):655-65. PubMed ID: 18056282
[TBL] [Abstract][Full Text] [Related]
3. Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.
Birkus G; Kutty N; He GX; Mulato A; Lee W; McDermott M; Cihlar T
Mol Pharmacol; 2008 Jul; 74(1):92-100. PubMed ID: 18430788
[TBL] [Abstract][Full Text] [Related]
4. Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors.
García-Lerma JG; Aung W; Cong ME; Zheng Q; Youngpairoj AS; Mitchell J; Holder A; Martin A; Kuklenyik S; Luo W; Lin CY; Hanson DL; Kersh E; Pau CP; Ray AS; Rooney JF; Lee WA; Heneine W
J Virol; 2011 Jul; 85(13):6610-7. PubMed ID: 21525346
[TBL] [Abstract][Full Text] [Related]
5. Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.
Mackman RL; Ray AS; Hui HC; Zhang L; Birkus G; Boojamra CG; Desai MC; Douglas JL; Gao Y; Grant D; Laflamme G; Lin KY; Markevitch DY; Mishra R; McDermott M; Pakdaman R; Petrakovsky OV; Vela JE; Cihlar T
Bioorg Med Chem; 2010 May; 18(10):3606-17. PubMed ID: 20409721
[TBL] [Abstract][Full Text] [Related]
6. Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood.
Eisenberg EJ; He GX; Lee WA
Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):1091-8. PubMed ID: 11562963
[TBL] [Abstract][Full Text] [Related]
7. Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.
Cihlar T; Laflamme G; Fisher R; Carey AC; Vela JE; Mackman R; Ray AS
Antimicrob Agents Chemother; 2009 Jan; 53(1):150-6. PubMed ID: 19001108
[TBL] [Abstract][Full Text] [Related]
8. Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue.
Dobard C; Sharma S; Martin A; Pau CP; Holder A; Kuklenyik Z; Lipscomb J; Hanson DL; Smith J; Novembre FJ; García-Lerma JG; Heneine W
J Virol; 2012 Jan; 86(2):718-25. PubMed ID: 22072766
[TBL] [Abstract][Full Text] [Related]
9. Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA.
Robbins BL; Srinivas RV; Kim C; Bischofberger N; Fridland A
Antimicrob Agents Chemother; 1998 Mar; 42(3):612-7. PubMed ID: 9517941
[TBL] [Abstract][Full Text] [Related]
10. Simultaneous determination of tenofovir alafenamide and its active metabolites tenofovir and tenofovir diphosphate in HBV-infected hepatocyte with a sensitive LC-MS/MS method.
Ouyang B; Zhou F; Zhen L; Peng Y; Sun J; Chen Q; Jin X; Wang G; Zhang J
J Pharm Biomed Anal; 2017 Nov; 146():147-153. PubMed ID: 28881311
[TBL] [Abstract][Full Text] [Related]
11. Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.
Frangeul A; Bussetta C; Deval J; Barral K; Alvarez K; Canard B
Antivir Ther; 2008; 13(1):115-24. PubMed ID: 18389906
[TBL] [Abstract][Full Text] [Related]
12. Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.
Lee WA; He GX; Eisenberg E; Cihlar T; Swaminathan S; Mulato A; Cundy KC
Antimicrob Agents Chemother; 2005 May; 49(5):1898-906. PubMed ID: 15855512
[TBL] [Abstract][Full Text] [Related]
13. Characterization of HIV-1 Resistance to Tenofovir Alafenamide In Vitro.
Margot NA; Johnson A; Miller MD; Callebaut C
Antimicrob Agents Chemother; 2015 Oct; 59(10):5917-24. PubMed ID: 26149983
[TBL] [Abstract][Full Text] [Related]
14. In vitro evaluation of the anti-HIV activity and metabolic interactions of tenofovir and emtricitabine.
Borroto-Esoda K; Vela JE; Myrick F; Ray AS; Miller MD
Antivir Ther; 2006; 11(3):377-84. PubMed ID: 16759055
[TBL] [Abstract][Full Text] [Related]
15. Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.
Birkus G; Wang R; Liu X; Kutty N; MacArthur H; Cihlar T; Gibbs C; Swaminathan S; Lee W; McDermott M
Antimicrob Agents Chemother; 2007 Feb; 51(2):543-50. PubMed ID: 17145787
[TBL] [Abstract][Full Text] [Related]
16. Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus.
Ray AS; Fordyce MW; Hitchcock MJ
Antiviral Res; 2016 Jan; 125():63-70. PubMed ID: 26640223
[TBL] [Abstract][Full Text] [Related]
17. Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors.
Birkus G; Bam RA; Willkom M; Frey CR; Tsai L; Stray KM; Yant SR; Cihlar T
Antimicrob Agents Chemother; 2016 Jan; 60(1):316-22. PubMed ID: 26503655
[TBL] [Abstract][Full Text] [Related]
18. Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection.
Kiser JJ; Fletcher CV; Flynn PM; Cunningham CK; Wilson CM; Kapogiannis BG; Major-Wilson H; Viani RM; Liu NX; Muenz LR; Harris DR; Havens PL;
Antimicrob Agents Chemother; 2008 Feb; 52(2):631-7. PubMed ID: 18025112
[TBL] [Abstract][Full Text] [Related]
19. Anti-HIV Nucleoside Phosphonate GS-9148 and Its Prodrug GS-9131: Scale Up of a 2'-F Modified Cyclic Nucleoside Phosphonate and Synthesis of Selected Amidate Prodrugs.
Mackman RL
Curr Protoc Nucleic Acid Chem; 2014 Mar; 56():14.10.1-21. PubMed ID: 25606977
[TBL] [Abstract][Full Text] [Related]
20. Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells.
Robbins BL; Wilcox CK; Fridland A; Rodman JH
Pharmacotherapy; 2003 Jun; 23(6):695-701. PubMed ID: 12820810
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
