BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

591 related articles for article (PubMed ID: 18056795)

  • 61. Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor.
    Heitman LH; Ye K; Oosterom J; Ijzerman AP
    Mol Pharmacol; 2008 Jun; 73(6):1808-15. PubMed ID: 18344315
    [TBL] [Abstract][Full Text] [Related]  

  • 62. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.
    Iso Y; Grajkowska E; Wroblewski JT; Davis J; Goeders NE; Johnson KM; Sanker S; Roth BL; Tueckmantel W; Kozikowski AP
    J Med Chem; 2006 Feb; 49(3):1080-100. PubMed ID: 16451073
    [TBL] [Abstract][Full Text] [Related]  

  • 63. Blockade of glutamate transporters leads to potentiation of NMDA receptor current in layer V pyramidal neurons of the rat prefrontal cortex via group II metabotropic glutamate receptor activation.
    Oliveira JF; Krügel U; Köles L; Illes P; Wirkner K
    Neuropharmacology; 2008 Sep; 55(4):447-53. PubMed ID: 18680754
    [TBL] [Abstract][Full Text] [Related]  

  • 64. Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia.
    Bradley SJ; Langmead CJ; Watson JM; Challiss RA
    Mol Pharmacol; 2011 May; 79(5):874-85. PubMed ID: 21321061
    [TBL] [Abstract][Full Text] [Related]  

  • 65. Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist.
    Gonsiorek W; Fan X; Hesk D; Fossetta J; Qiu H; Jakway J; Billah M; Dwyer M; Chao J; Deno G; Taveras A; Lundell DJ; Hipkin RW
    J Pharmacol Exp Ther; 2007 Aug; 322(2):477-85. PubMed ID: 17496166
    [TBL] [Abstract][Full Text] [Related]  

  • 66. Computational analysis of negative and positive allosteric modulator binding and function in metabotropic glutamate receptor 5 (in)activation.
    Dalton JA; Gómez-Santacana X; Llebaria A; Giraldo J
    J Chem Inf Model; 2014 May; 54(5):1476-87. PubMed ID: 24793143
    [TBL] [Abstract][Full Text] [Related]  

  • 67. Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5.
    Lucatelli C; Honer M; Salazar JF; Ross TL; Schubiger PA; Ametamey SM
    Nucl Med Biol; 2009 Aug; 36(6):613-22. PubMed ID: 19647167
    [TBL] [Abstract][Full Text] [Related]  

  • 68. The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices.
    Liu F; Zhang G; Hornby G; Vasylyev D; Bowlby M; Park K; Gilbert A; Marquis K; Andree TH
    Eur J Pharmacol; 2006 May; 536(3):262-8. PubMed ID: 16600209
    [TBL] [Abstract][Full Text] [Related]  

  • 69. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.
    Pollard M; Bartolome JM; Conn PJ; Steckler T; Shaban H
    J Psychopharmacol; 2014 Oct; 28(10):935-46. PubMed ID: 25031220
    [TBL] [Abstract][Full Text] [Related]  

  • 70. Molecular determinants of metabotropic glutamate receptor 1B trafficking.
    Chan WY; Soloviev MM; Ciruela F; McIlhinney RA
    Mol Cell Neurosci; 2001 Mar; 17(3):577-88. PubMed ID: 11273651
    [TBL] [Abstract][Full Text] [Related]  

  • 71. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site.
    Jacobson MA; Kreatsoulas C; Pascarella DM; O'Brien JA; Sur C
    Mol Pharmacol; 2010 Oct; 78(4):648-57. PubMed ID: 20660086
    [TBL] [Abstract][Full Text] [Related]  

  • 72. An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats.
    Ossowska K; Konieczny J; Wardas J; Pietraszek M; Kuter K; Wolfarth S; Pilc A
    Amino Acids; 2007 Feb; 32(2):179-88. PubMed ID: 16699817
    [TBL] [Abstract][Full Text] [Related]  

  • 73. A novel constitutively active mutation in the second cytoplasmic loop of metabotropic glutamate receptor.
    Yamashita T; Kai T; Terakita A; Shichida Y
    J Neurochem; 2004 Oct; 91(2):484-92. PubMed ID: 15447681
    [TBL] [Abstract][Full Text] [Related]  

  • 74. Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
    Tränkle C; Weyand O; Voigtländer U; Mynett A; Lazareno S; Birdsall NJ; Mohr K
    Mol Pharmacol; 2003 Jul; 64(1):180-90. PubMed ID: 12815174
    [TBL] [Abstract][Full Text] [Related]  

  • 75. Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.
    Gregory KJ; Nguyen ED; Reiff SD; Squire EF; Stauffer SR; Lindsley CW; Meiler J; Conn PJ
    Mol Pharmacol; 2013 May; 83(5):991-1006. PubMed ID: 23444015
    [TBL] [Abstract][Full Text] [Related]  

  • 76. Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists.
    Johnson MP; Nisenbaum ES; Large TH; Emkey R; Baez M; Kingston AE
    Biochem Soc Trans; 2004 Nov; 32(Pt 5):881-7. PubMed ID: 15494040
    [TBL] [Abstract][Full Text] [Related]  

  • 77. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors.
    Hemstapat K; Da Costa H; Nong Y; Brady AE; Luo Q; Niswender CM; Tamagnan GD; Conn PJ
    J Pharmacol Exp Ther; 2007 Jul; 322(1):254-64. PubMed ID: 17416742
    [TBL] [Abstract][Full Text] [Related]  

  • 78. Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory.
    Gass JT; Olive MF
    Biol Psychiatry; 2009 Apr; 65(8):717-20. PubMed ID: 19100966
    [TBL] [Abstract][Full Text] [Related]  

  • 79. Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation.
    Jullian N; Brabet I; Pin JP; Acher FC
    J Med Chem; 1999 May; 42(9):1546-55. PubMed ID: 10229625
    [TBL] [Abstract][Full Text] [Related]  

  • 80. Determining calmodulin binding to metabotropic glutamate receptors with distinct protein-interaction methods.
    Lidwell K; Dillon J; Sihota A; O'Connor V; Pilkington B
    Biochem Soc Trans; 2004 Nov; 32(Pt 5):868-70. PubMed ID: 15494036
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 30.