BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

234 related articles for article (PubMed ID: 18056975)

  • 1. Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease.
    Cox LS; Clancy DJ; Boubriak I; Saunders RD
    Ann N Y Acad Sci; 2007 Nov; 1119():274-88. PubMed ID: 18056975
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.
    Saunders RD; Boubriak I; Clancy DJ; Cox LS
    Aging Cell; 2008 Jun; 7(3):418-25. PubMed ID: 18346216
    [TBL] [Abstract][Full Text] [Related]  

  • 3. DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease.
    Boubriak I; Mason PA; Clancy DJ; Dockray J; Saunders RD; Cox LS
    Biogerontology; 2009 Jun; 10(3):267-77. PubMed ID: 18956248
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro.
    Mason PA; Boubriak I; Robbins T; Lasala R; Saunders R; Cox LS
    Age (Dordr); 2013 Jun; 35(3):793-806. PubMed ID: 22562358
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.
    Opresko PL; Sowd G; Wang H
    PLoS One; 2009; 4(3):e4825. PubMed ID: 19283071
    [TBL] [Abstract][Full Text] [Related]  

  • 6. WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3.
    Aggarwal M; Brosh RM
    Aging (Albany NY); 2009 Feb; 1(2):219-33. PubMed ID: 20157511
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.
    Shen JC; Gray MD; Oshima J; Kamath-Loeb AS; Fry M; Loeb LA
    J Biol Chem; 1998 Dec; 273(51):34139-44. PubMed ID: 9852073
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.
    Opresko PL; Laine JP; Brosh RM; Seidman MM; Bohr VA
    J Biol Chem; 2001 Nov; 276(48):44677-87. PubMed ID: 11572872
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex.
    Li B; Comai L
    J Biol Chem; 2001 Mar; 276(13):9896-902. PubMed ID: 11152456
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dietary restriction fails to extend lifespan of Drosophila model of Werner syndrome.
    Sember E; Chennakesavula R; Beard B; Opoola M; Hwangbo DS
    G3 (Bethesda); 2024 May; 14(5):. PubMed ID: 38491858
    [TBL] [Abstract][Full Text] [Related]  

  • 11. DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities.
    Tadokoro T; Kulikowicz T; Dawut L; Croteau DL; Bohr VA
    Aging (Albany NY); 2012 Jun; 4(6):417-29. PubMed ID: 22713343
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A fluorescence-based exonuclease assay to characterize DmWRNexo, orthologue of human progeroid WRN exonuclease, and its application to other nucleases.
    Mason PA; Boubriak I; Cox LS
    J Vis Exp; 2013 Dec; (82):e50722. PubMed ID: 24378758
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
    Friedemann J; Grosse F; Zhang S
    J Biol Chem; 2005 Sep; 280(35):31303-13. PubMed ID: 15995249
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Lack of WRN results in extensive deletion at nonhomologous joining ends.
    Oshima J; Huang S; Pae C; Campisi J; Schiestl RH
    Cancer Res; 2002 Jan; 62(2):547-51. PubMed ID: 11809708
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain.
    Lee JW; Kusumoto R; Doherty KM; Lin GX; Zeng W; Cheng WH; von Kobbe C; Brosh RM; Hu JS; Bohr VA
    J Biol Chem; 2005 Nov; 280(47):39627-36. PubMed ID: 16150736
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Enzymatic mechanism of the WRN helicase/nuclease.
    Brosh RM; Opresko PL; Bohr VA
    Methods Enzymol; 2006; 409():52-85. PubMed ID: 16793395
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Werner's Syndrome RecQ helicase/exonuclease at the nexus of cancer and aging.
    Chun SG; Shaeffer DS; Bryant-Greenwood PK
    Hawaii Med J; 2011 Mar; 70(3):52-5. PubMed ID: 21365542
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.
    Bolterstein E; Rivero R; Marquez M; McVey M
    Genetics; 2014 Jun; 197(2):643-52. PubMed ID: 24709634
    [TBL] [Abstract][Full Text] [Related]  

  • 19. WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.
    Chen L; Huang S; Lee L; Davalos A; Schiestl RH; Campisi J; Oshima J
    Aging Cell; 2003 Aug; 2(4):191-9. PubMed ID: 12934712
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.
    Orren DK; Theodore S; Machwe A
    Biochemistry; 2002 Nov; 41(46):13483-8. PubMed ID: 12427008
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.