BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

155 related articles for article (PubMed ID: 18068983)

  • 1. Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.
    Jennings LD; Cole DC; Stock JR; Sukhdeo MN; Ellingboe JW; Cowling R; Jin G; Manas ES; Fan KY; Malamas MS; Harrison BL; Jacobsen S; Chopra R; Lohse PA; Moore WJ; O'Donnell MM; Hu Y; Robichaud AJ; Turner MJ; Wagner E; Bard J
    Bioorg Med Chem Lett; 2008 Jan; 18(2):767-71. PubMed ID: 18068983
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
    Cole DC; Stock JR; Chopra R; Cowling R; Ellingboe JW; Fan KY; Harrison BL; Hu Y; Jacobsen S; Jennings LD; Jin G; Lohse PA; Malamas MS; Manas ES; Moore WJ; O'Donnell MM; Olland AM; Robichaud AJ; Svenson K; Wu J; Wagner E; Bard J
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1063-6. PubMed ID: 18162398
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural optimization of a CXCR2-directed antagonist that indirectly inhibits gamma-secretase and reduces Abeta.
    Bakshi P; Jin C; Broutin P; Berhane B; Reed J; Mullan M
    Bioorg Med Chem; 2009 Dec; 17(23):8102-12. PubMed ID: 19853461
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Progress toward the discovery and development of efficacious BACE inhibitors.
    Durham TB; Shepherd TA
    Curr Opin Drug Discov Devel; 2006 Nov; 9(6):776-91. PubMed ID: 17117686
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
    Pu J; Kreft AF; Aschmies SH; Atchison KP; Berkowitz J; Caggiano TJ; Chlenov M; Diamantidis G; Harrison BL; Hu Y; Huryn D; Steven Jacobsen J; Jin M; Lipinski K; Lu P; Martone RL; Morris K; Sonnenberg-Reines J; Riddell DR; Sabalski J; Sun SC; Wagner E; Wang Y; Xu Z; Zhou H; Resnick L
    Bioorg Med Chem; 2009 Jul; 17(13):4708-17. PubMed ID: 19443228
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
    Nowak P; Cole DC; Aulabaugh A; Bard J; Chopra R; Cowling R; Fan KY; Hu B; Jacobsen S; Jani M; Jin G; Lo MC; Malamas MS; Manas ES; Narasimhan R; Reinhart P; Robichaud AJ; Stock JR; Subrath J; Svenson K; Turner J; Wagner E; Zhou P; Ellingboe JW
    Bioorg Med Chem Lett; 2010 Jan; 20(2):632-5. PubMed ID: 19959359
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.
    Zhu Y; Xiao K; Ma L; Xiong B; Fu Y; Yu H; Wang W; Wang X; Hu D; Peng H; Li J; Gong Q; Chai Q; Tang X; Zhang H; Li J; Shen J
    Bioorg Med Chem; 2009 Feb; 17(4):1600-13. PubMed ID: 19162488
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Calculation of the binding affinity of beta-secretase inhibitors using the linear interaction energy method.
    Tounge BA; Reynolds CH
    J Med Chem; 2003 May; 46(11):2074-82. PubMed ID: 12747779
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Secretase inhibitors and modulators for Alzheimer's disease treatment.
    Tomita T
    Expert Rev Neurother; 2009 May; 9(5):661-79. PubMed ID: 19402777
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core.
    Björklund C; Adolfsson H; Jansson K; Lindberg J; Vrang L; Hallberg A; Rosenquist S; Samuelsson B
    Bioorg Med Chem; 2010 Feb; 18(4):1711-23. PubMed ID: 20122837
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects.
    Wu G; Sankaranarayanan S; Tugusheva K; Kahana J; Seabrook G; Shi XP; King E; Devanarayan V; Cook JJ; Simon AJ
    Clin Biochem; 2008 Aug; 41(12):986-96. PubMed ID: 18489907
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening.
    Xu W; Chen G; Zhu W; Zuo Z
    Bioorg Med Chem Lett; 2010 Oct; 20(19):5763-6. PubMed ID: 20732815
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
    Wang YS; Strickland C; Voigt JH; Kennedy ME; Beyer BM; Senior MM; Smith EM; Nechuta TL; Madison VS; Czarniecki M; McKittrick BA; Stamford AW; Parker EM; Hunter JC; Greenlee WJ; Wyss DF
    J Med Chem; 2010 Feb; 53(3):942-50. PubMed ID: 20043700
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Development and characterization of beta-secretase monolithic micro-immobilized enzyme reactor for on-line high-performance liquid chromatography studies.
    Mancini F; Naldi M; Cavrini V; Andrisano V
    J Chromatogr A; 2007 Dec; 1175(2):217-26. PubMed ID: 17991476
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
    Machauer R; Laumen K; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Jaton AL; Desrayaud S; Staufenbiel M; Rabe S; Paganetti P; Neumann U
    Bioorg Med Chem Lett; 2009 Mar; 19(5):1366-70. PubMed ID: 19195887
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism.
    Succol F; Praticò D
    J Neurochem; 2007 Oct; 103(1):380-7. PubMed ID: 17877641
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
    Baxter EW; Conway KA; Kennis L; Bischoff F; Mercken MH; Winter HL; Reynolds CH; Tounge BA; Luo C; Scott MK; Huang Y; Braeken M; Pieters SM; Berthelot DJ; Masure S; Bruinzeel WD; Jordan AD; Parker MH; Boyd RE; Qu J; Alexander RS; Brenneman DE; Reitz AB
    J Med Chem; 2007 Sep; 50(18):4261-4. PubMed ID: 17685503
    [TBL] [Abstract][Full Text] [Related]  

  • 20. beta-Secretase inhibitor increases amyloid-beta precursor protein level in rat brain cortical primary neurons induced by okadaic acid.
    Yu CJ; Wang WZ; Liu W
    Chin Med J (Engl); 2008 Aug; 121(15):1439-44. PubMed ID: 18959123
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.