BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

156 related articles for article (PubMed ID: 18071909)

  • 1. Modeling the inhibition of quadruple mutant Plasmodium falciparum dihydrofolate reductase by pyrimethamine derivatives.
    Fogel GB; Cheung M; Pittman E; Hecht D
    J Comput Aided Mol Des; 2008 Jan; 22(1):29-38. PubMed ID: 18071909
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase.
    Fogel GB; Cheung M; Pittman E; Hecht D
    J Mol Graph Model; 2008 Apr; 26(7):1145-52. PubMed ID: 18037315
    [TBL] [Abstract][Full Text] [Related]  

  • 3. QSAR using evolved neural networks for the inhibition of mutant PfDHFR by pyrimethamine derivatives.
    Hecht D; Cheung M; Fogel GB
    Biosystems; 2008 Apr; 92(1):10-5. PubMed ID: 18160210
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites.
    Sardarian A; Douglas KT; Read M; Sims PF; Hyde JE; Chitnumsub P; Sirawaraporn R; Sirawaraporn W
    Org Biomol Chem; 2003 Mar; 1(6):960-4. PubMed ID: 12929634
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Plasmodium falciparum: kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase.
    Hekmat-Nejad M; Rathod PK
    Exp Parasitol; 1997 Nov; 87(3):222-8. PubMed ID: 9371087
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum.
    Wooden JM; Hartwell LH; Vasquez B; Sibley CH
    Mol Biochem Parasitol; 1997 Mar; 85(1):25-40. PubMed ID: 9108546
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant.
    Sirawaraporn W; Yongkiettrakul S; Sirawaraporn R; Yuthavong Y; Santi DV
    Exp Parasitol; 1997 Nov; 87(3):245-52. PubMed ID: 9371090
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.
    Bunyarataphan S; Leartsakulpanich U; Taweechai S; Tarnchompoo B; Kamchonwongpaisan S; Yuthavong Y
    Antimicrob Agents Chemother; 2006 Nov; 50(11):3631-7. PubMed ID: 16954316
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.
    Mokmak W; Chunsrivirot S; Hannongbua S; Yuthavong Y; Tongsima S; Kamchonwongpaisan S
    Chem Biol Drug Des; 2014 Oct; 84(4):450-61. PubMed ID: 24716467
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Altered dihydrofolate reductase in pyrimethamine-resistant Plasmodium falciparum.
    Walter RD
    Mol Biochem Parasitol; 1986 Apr; 19(1):61-6. PubMed ID: 3520313
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutagenesis of dihydrofolate reductase from Plasmodium falciparum: analysis in Saccharomyces cerevisiae of triple mutant alleles resistant to pyrimethamine or WR99210.
    Ferlan JT; Mookherjee S; Okezie IN; Fulgence L; Sibley CH
    Mol Biochem Parasitol; 2001 Mar; 113(1):139-50. PubMed ID: 11254962
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Computational analysis of binding between malarial dihydrofolate reductases and anti-folates.
    Choowongkomon K; Theppabutr S; Songtawee N; Day NP; White NJ; Woodrow CJ; Imwong M
    Malar J; 2010 Mar; 9():65. PubMed ID: 20193090
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular epidemiology of malaria in Yaounde, Cameroon. VI. Sequence variations in the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene and in vitro resistance to pyrimethamine and cycloguanil.
    Basco LK; Ringwald P
    Am J Trop Med Hyg; 2000 Feb; 62(2):271-6. PubMed ID: 10813484
    [TBL] [Abstract][Full Text] [Related]  

  • 14. An amino acid substitution in the Babesia bovis dihydrofolate reductase-thymidylate synthase gene is correlated to cross-resistance against pyrimethamine and WR99210.
    Gaffar FR; Wilschut K; Franssen FF; de Vries E
    Mol Biochem Parasitol; 2004 Feb; 133(2):209-19. PubMed ID: 14698433
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
    Tarnchompoo B; Sirichaiwat C; Phupong W; Intaraudom C; Sirawaraporn W; Kamchonwongpaisan S; Vanichtanankul J; Thebtaranonth Y; Yuthavong Y
    J Med Chem; 2002 Mar; 45(6):1244-52. PubMed ID: 11881993
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Shape- and chemical feature-based 3D-pharmacophore model generation and virtual screening: identification of potential leads for P. falciparum DHFR enzyme inhibition.
    Adane L; Patel DS; Bharatam PV
    Chem Biol Drug Des; 2010 Jan; 75(1):115-26. PubMed ID: 19895504
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular modeling of wild-type and antifolate resistant mutant Plasmodium falciparum DHFR.
    Delfino RT; Santos-Filho OA; Figueroa-Villar JD
    Biophys Chem; 2002 Aug; 98(3):287-300. PubMed ID: 12128181
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
    Kamchonwongpaisan S; Quarrell R; Charoensetakul N; Ponsinet R; Vilaivan T; Vanichtanankul J; Tarnchompoo B; Sirawaraporn W; Lowe G; Yuthavong Y
    J Med Chem; 2004 Jan; 47(3):673-80. PubMed ID: 14736247
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance.
    Santos-Filho OA; de Alencastro RB; Figueroa-Villar JD
    Biophys Chem; 2001 Jul; 91(3):305-17. PubMed ID: 11551441
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.
    McKie JH; Douglas KT; Chan C; Roser SA; Yates R; Read M; Hyde JE; Dascombe MJ; Yuthavong Y; Sirawaraporn W
    J Med Chem; 1998 Apr; 41(9):1367-70. PubMed ID: 9554869
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.