215 related articles for article (PubMed ID: 18086667)
21. Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode.
Divya N; Grifith E; Narayana N
Protein Sci; 2007 Jun; 16(6):1063-8. PubMed ID: 17473013
[TBL] [Abstract][Full Text] [Related]
22. One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.
Howell EE; Shukla U; Hicks SN; Smiley RD; Kuhn LA; Zavodszky MI
J Comput Aided Mol Des; 2001 Nov; 15(11):1035-52. PubMed ID: 11989624
[TBL] [Abstract][Full Text] [Related]
23. Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.
Venkitakrishnan RP; Zaborowski E; McElheny D; Benkovic SJ; Dyson HJ; Wright PE
Biochemistry; 2004 Dec; 43(51):16046-55. PubMed ID: 15609999
[TBL] [Abstract][Full Text] [Related]
24. "Catch 222," the effects of symmetry on ligand binding and catalysis in R67 dihydrofolate reductase as determined by mutations at Tyr-69.
Stinnett LG; Smiley RD; Hicks SN; Howell EE
J Biol Chem; 2004 Nov; 279(45):47003-9. PubMed ID: 15333637
[TBL] [Abstract][Full Text] [Related]
25. Multiple ligand-binding modes in bacterial R67 dihydrofolate reductase.
Alonso H; Gillies MB; Cummins PL; Bliznyuk AA; Gready JE
J Comput Aided Mol Des; 2005 Mar; 19(3):165-87. PubMed ID: 16059670
[TBL] [Abstract][Full Text] [Related]
26. Artificial duplication of the R67 dihydrofolate reductase gene to create protein asymmetry. Effects on protein activity and folding.
Zhuang P; Yin M; Holland JC; Peterson CB; Howell EE
J Biol Chem; 1993 Oct; 268(30):22672-9. PubMed ID: 8226776
[TBL] [Abstract][Full Text] [Related]
27. Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
Oyen D; Fenwick RB; Stanfield RL; Dyson HJ; Wright PE
J Am Chem Soc; 2015 Jul; 137(29):9459-68. PubMed ID: 26147643
[TBL] [Abstract][Full Text] [Related]
28. Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase.
Bastien D; Ebert MC; Forge D; Toulouse J; Kadnikova N; Perron F; Mayence A; Huang TL; Vanden Eynde JJ; Pelletier JN
J Med Chem; 2012 Apr; 55(7):3182-92. PubMed ID: 22424148
[TBL] [Abstract][Full Text] [Related]
29. Insight into the molecular mechanism about lowered dihydrofolate binding affinity to dihydrofolate reductase-like 1 (DHFRL1).
Gao J; Cui W; Du Y; Ji M
J Mol Model; 2013 Dec; 19(12):5187-98. PubMed ID: 24122410
[TBL] [Abstract][Full Text] [Related]
30. R67, the other dihydrofolate reductase: rational design of an alternate active site configuration.
Feng J; Goswami S; Howell EE
Biochemistry; 2008 Jan; 47(2):555-65. PubMed ID: 18085798
[TBL] [Abstract][Full Text] [Related]
31. Role of water in the catalytic cycle of E. coli dihydrofolate reductase.
Shrimpton P; Allemann RK
Protein Sci; 2002 Jun; 11(6):1442-51. PubMed ID: 12021443
[TBL] [Abstract][Full Text] [Related]
32. Construction of a synthetic gene for an R-plasmid-encoded dihydrofolate reductase and studies on the role of the N-terminus in the protein.
Reece LJ; Nichols R; Ogden RC; Howell EE
Biochemistry; 1991 Nov; 30(45):10895-904. PubMed ID: 1932013
[TBL] [Abstract][Full Text] [Related]
33. Small Angle Neutron Scattering Studies of R67 Dihydrofolate Reductase, a Tetrameric Protein with Intrinsically Disordered N-Termini.
Bhojane PP; Duff MR; Bafna K; Agarwal P; Stanley C; Howell EE
Biochemistry; 2017 Nov; 56(44):5886-5899. PubMed ID: 29020453
[TBL] [Abstract][Full Text] [Related]
34. Structural Characterization of Dihydrofolate Reductase Complexes by Top-Down Ultraviolet Photodissociation Mass Spectrometry.
Cammarata MB; Thyer R; Rosenberg J; Ellington A; Brodbelt JS
J Am Chem Soc; 2015 Jul; 137(28):9128-35. PubMed ID: 26125523
[TBL] [Abstract][Full Text] [Related]
35. Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase.
Batruch I; Javasky E; Brown ED; Organ MG; Johnson PE
Bioorg Med Chem; 2010 Dec; 18(24):8485-92. PubMed ID: 21084197
[TBL] [Abstract][Full Text] [Related]
36. Searching sequence space: two different approaches to dihydrofolate reductase catalysis.
Howell EE
Chembiochem; 2005 Apr; 6(4):590-600. PubMed ID: 15812782
[TBL] [Abstract][Full Text] [Related]
37. The conformations of trimethoprim/E. coli dihydrofolate reductase complexes. A 15N and 31P NMR study.
Huang FY; Yang QX; Huang TH; Gelbaum L; Kuyper LF
FEBS Lett; 1991 May; 283(1):44-6. PubMed ID: 2037072
[TBL] [Abstract][Full Text] [Related]
38.
Nambiar D; Berhane TK; Shew R; Schwarz B; Duff MR; Howell EE
Appl Environ Microbiol; 2018 Oct; 84(19):. PubMed ID: 30030232
[TBL] [Abstract][Full Text] [Related]
39. Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Cheng YS; Sacchettini JC
Biochemistry; 2016 Feb; 55(7):1107-19. PubMed ID: 26848874
[TBL] [Abstract][Full Text] [Related]
40. Effects of temperature and viscosity on R67 dihydrofolate reductase catalysis.
Chopra S; Lynch R; Kim SH; Jackson M; Howell EE
Biochemistry; 2006 May; 45(21):6596-605. PubMed ID: 16716070
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]