BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1555 related articles for article (PubMed ID: 18156464)

  • 21. First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
    Sankaranarayanan S; Holahan MA; Colussi D; Crouthamel MC; Devanarayan V; Ellis J; Espeseth A; Gates AT; Graham SL; Gregro AR; Hazuda D; Hochman JH; Holloway K; Jin L; Kahana J; Lai MT; Lineberger J; McGaughey G; Moore KP; Nantermet P; Pietrak B; Price EA; Rajapakse H; Stauffer S; Steinbeiser MA; Seabrook G; Selnick HG; Shi XP; Stanton MG; Swestock J; Tugusheva K; Tyler KX; Vacca JP; Wong J; Wu G; Xu M; Cook JJ; Simon AJ
    J Pharmacol Exp Ther; 2009 Jan; 328(1):131-40. PubMed ID: 18854490
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.
    Kienlen-Campard P; Feyt C; Huysseune S; de Diesbach P; N'Kuli F; Courtoy PJ; Octave JN
    J Neurosci Res; 2006 Nov; 84(6):1311-22. PubMed ID: 16941495
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S; Anderson JP; Barbour R; Basi GS; Caccavello R; Davis D; Doan M; Dovey HF; Frigon N; Hong J; Jacobson-Croak K; Jewett N; Keim P; Knops J; Lieberburg I; Power M; Tan H; Tatsuno G; Tung J; Schenk D; Seubert P; Suomensaari SM; Wang S; Walker D; Zhao J; McConlogue L; John V
    Nature; 1999 Dec; 402(6761):537-40. PubMed ID: 10591214
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.
    Volbracht C; Penzkofer S; Mansson D; Christensen KV; Fog K; Schildknecht S; Leist M; Nielsen J
    Anal Biochem; 2009 Apr; 387(2):208-20. PubMed ID: 19454261
    [TBL] [Abstract][Full Text] [Related]  

  • 25. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters.
    Lin HC; Hsieh HM; Chen YH; Hu ML
    Neurotoxicology; 2009 Jul; 30(4):622-7. PubMed ID: 19635394
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S; Amtul Z; Newbigging S; Westaway D; St George-Hyslop P; Rozmahel RF
    Neurobiol Dis; 2007 Feb; 25(2):291-6. PubMed ID: 17071095
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
    Wu G; Sankaranarayanan S; Hsieh SH; Simon AJ; Savage MJ
    J Neurosci Res; 2011 Jun; 89(6):822-32. PubMed ID: 21433051
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
    Philipson O; Lannfelt L; Nilsson LN
    FEBS Lett; 2009 Sep; 583(18):3021-6. PubMed ID: 19683527
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Kuzuya A; Uemura K; Kitagawa N; Aoyagi N; Kihara T; Ninomiya H; Ishiura S; Takahashi R; Shimohama S
    J Neurosci Res; 2007 Jan; 85(1):153-65. PubMed ID: 17075903
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
    Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
    Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
    [TBL] [Abstract][Full Text] [Related]  

  • 32. 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice.
    Zhu Z; Li C; Wang X; Yang Z; Chen J; Hu L; Jiang H; Shen X
    J Neurochem; 2010 Jul; 114(2):374-85. PubMed ID: 20412384
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
    Ohno M; Chang L; Tseng W; Oakley H; Citron M; Klein WL; Vassar R; Disterhoft JF
    Eur J Neurosci; 2006 Jan; 23(1):251-60. PubMed ID: 16420434
    [TBL] [Abstract][Full Text] [Related]  

  • 34. New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity.
    Yang HQ; Pan J; Ba MW; Sun ZK; Ma GZ; Lu GQ; Xiao Q; Chen SD
    Eur J Neurosci; 2007 Jul; 26(2):381-91. PubMed ID: 17650113
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
    Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
    J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides.
    Zhang Q; Yang G; Li W; Fan Z; Sun A; Luo J; Ke ZJ
    Neurobiol Aging; 2011 Jan; 32(1):42-53. PubMed ID: 19233513
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice.
    Zohar O; Pick CG; Cavallaro S; Chapman J; Katzav A; Milman A; Alkon DL
    Neurobiol Aging; 2005; 26(8):1167-75. PubMed ID: 15917100
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.
    Liu K; Solano I; Mann D; Lemere C; Mercken M; Trojanowski JQ; Lee VM
    Acta Neuropathol; 2006 Aug; 112(2):163-74. PubMed ID: 16865398
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.
    Georgievska B; Gustavsson S; Lundkvist J; Neelissen J; Eketjäll S; Ramberg V; Bueters T; Agerman K; Juréus A; Svensson S; Berg S; Fälting J; Lendahl U
    J Neurochem; 2015 Feb; 132(4):477-86. PubMed ID: 25156639
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
    Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA
    Biochem J; 2005 Jan; 385(Pt 2):545-50. PubMed ID: 15473868
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 78.