BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 18160664)

  • 1. Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia.
    Huang XF; Luo SK; Xu J; Li J; Xu DR; Wang LH; Yan M; Wang XR; Wan XB; Zheng FM; Zeng YX; Liu Q
    Blood; 2008 Mar; 111(5):2854-65. PubMed ID: 18160664
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells.
    Xu DR; Huang S; Long ZJ; Chen JJ; Zou ZZ; Li J; Lin DJ; Liu Q
    J Transl Med; 2011 May; 9():74. PubMed ID: 21600017
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aurora kinase small molecule inhibitor destroys mitotic spindle, suppresses cell growth, and induces apoptosis in oral squamous cancer cells.
    Pan C; Yan M; Yao J; Xu J; Long Z; Huang H; Liu Q
    Oral Oncol; 2008 Jul; 44(7):639-45. PubMed ID: 17996488
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells.
    Guan Z; Wang XR; Zhu XF; Huang XF; Xu J; Wang LH; Wan XB; Long ZJ; Liu JN; Feng GK; Huang W; Zeng YX; Chen FJ; Liu Q
    Cancer Res; 2007 Nov; 67(21):10436-44. PubMed ID: 17974987
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells.
    Grundy M; Seedhouse C; Shang S; Richardson J; Russell N; Pallis M
    Mol Cancer Ther; 2010 Mar; 9(3):661-72. PubMed ID: 20159992
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target.
    Hartsink-Segers SA; Zwaan CM; Exalto C; Luijendijk MW; Calvert VS; Petricoin EF; Evans WE; Reinhardt D; de Haas V; Hedtjärn M; Hansen BR; Koch T; Caron HN; Pieters R; Den Boer ML
    Leukemia; 2013 Mar; 27(3):560-8. PubMed ID: 22940834
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells.
    Wan XB; Long ZJ; Yan M; Xu J; Xia LP; Liu L; Zhao Y; Huang XF; Wang XR; Zhu XF; Hong MH; Liu Q
    Carcinogenesis; 2008 Oct; 29(10):1930-7. PubMed ID: 18667445
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of Aurora-A results in increased cell death in 3-dimensional culture microenvironment, reduced migration and is associated with enhanced radiosensitivity in human nasopharyngeal carcinoma.
    Wan XB; Fan XJ; Chen MY; Xu J; Long ZJ; Hua YJ; Ji H; Liu L; Hong MH; Zeng YX; Liu Q
    Cancer Biol Ther; 2009 Aug; 8(15):1500-6. PubMed ID: 19502819
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism.
    Kelly KR; Nawrocki ST; Espitia CM; Zhang M; Yang JJ; Padmanabhan S; Ecsedy J; Giles FJ; Carew JS
    Int J Cancer; 2012 Dec; 131(11):2693-703. PubMed ID: 22488249
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia.
    Kojima K; Konopleva M; Tsao T; Nakakuma H; Andreeff M
    Blood; 2008 Oct; 112(7):2886-95. PubMed ID: 18633130
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.
    Kim JS; Eom JI; Cheong JW; Choi AJ; Lee JK; Yang WI; Min YH
    Clin Cancer Res; 2007 Feb; 13(3):1019-28. PubMed ID: 17289898
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells.
    Rao J; Xu DR; Zheng FM; Long ZJ; Huang SS; Wu X; Zhou WH; Huang RW; Liu Q
    J Transl Med; 2011 May; 9():71. PubMed ID: 21595920
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival.
    Yao JE; Yan M; Guan Z; Pan CB; Xia LP; Li CX; Wang LH; Long ZJ; Zhao Y; Li MW; Zheng FM; Xu J; Lin DJ; Liu Q
    Mol Cancer; 2009 Nov; 8():95. PubMed ID: 19891769
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Vincristine potentiates the anti-proliferative effect of an aurora kinase inhibitor, VE-465, in myeloid leukemia cells.
    Yoshida K; Nagai T; Ohmine K; Uesawa M; Sripayap P; Ishida Y; Ozawa K
    Biochem Pharmacol; 2011 Dec; 82(12):1884-90. PubMed ID: 21971583
    [TBL] [Abstract][Full Text] [Related]  

  • 15. VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.
    Tyler RK; Shpiro N; Marquez R; Eyers PA
    Cell Cycle; 2007 Nov; 6(22):2846-54. PubMed ID: 18032922
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
    Zeng Z; Samudio IJ; Zhang W; Estrov Z; Pelicano H; Harris D; Frolova O; Hail N; Chen W; Kornblau SM; Huang P; Lu Y; Mills GB; Andreeff M; Konopleva M
    Cancer Res; 2006 Apr; 66(7):3737-46. PubMed ID: 16585200
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dawn of Aurora kinase inhibitors as anticancer drugs.
    Doggrell SA
    Expert Opin Investig Drugs; 2004 Sep; 13(9):1199-201. PubMed ID: 15330750
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe.
    Cheong JW; Jung HI; Eom JI; Kim SJ; Jeung HK; Min YH
    Cancer Lett; 2010 Nov; 297(2):171-81. PubMed ID: 20547440
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets.
    de Paula Careta F; Gobessi S; Panepucci RA; Bojnik E; Morato de Oliveira F; Mazza Matos D; Falcão RP; Laurenti L; Zago MA; Efremov DG
    Haematologica; 2012 Aug; 97(8):1246-54. PubMed ID: 22331265
    [TBL] [Abstract][Full Text] [Related]  

  • 20. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.
    Oke A; Pearce D; Wilkinson RW; Crafter C; Odedra R; Cavenagh J; Fitzgibbon J; Lister AT; Joel S; Bonnet D
    Cancer Res; 2009 May; 69(10):4150-8. PubMed ID: 19366807
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.