These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

244 related articles for article (PubMed ID: 18160664)

  • 1. Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia.
    Huang XF; Luo SK; Xu J; Li J; Xu DR; Wang LH; Yan M; Wang XR; Wan XB; Zheng FM; Zeng YX; Liu Q
    Blood; 2008 Mar; 111(5):2854-65. PubMed ID: 18160664
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells.
    Xu DR; Huang S; Long ZJ; Chen JJ; Zou ZZ; Li J; Lin DJ; Liu Q
    J Transl Med; 2011 May; 9():74. PubMed ID: 21600017
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aurora kinase small molecule inhibitor destroys mitotic spindle, suppresses cell growth, and induces apoptosis in oral squamous cancer cells.
    Pan C; Yan M; Yao J; Xu J; Long Z; Huang H; Liu Q
    Oral Oncol; 2008 Jul; 44(7):639-45. PubMed ID: 17996488
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells.
    Guan Z; Wang XR; Zhu XF; Huang XF; Xu J; Wang LH; Wan XB; Long ZJ; Liu JN; Feng GK; Huang W; Zeng YX; Chen FJ; Liu Q
    Cancer Res; 2007 Nov; 67(21):10436-44. PubMed ID: 17974987
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells.
    Grundy M; Seedhouse C; Shang S; Richardson J; Russell N; Pallis M
    Mol Cancer Ther; 2010 Mar; 9(3):661-72. PubMed ID: 20159992
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target.
    Hartsink-Segers SA; Zwaan CM; Exalto C; Luijendijk MW; Calvert VS; Petricoin EF; Evans WE; Reinhardt D; de Haas V; Hedtjärn M; Hansen BR; Koch T; Caron HN; Pieters R; Den Boer ML
    Leukemia; 2013 Mar; 27(3):560-8. PubMed ID: 22940834
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells.
    Wan XB; Long ZJ; Yan M; Xu J; Xia LP; Liu L; Zhao Y; Huang XF; Wang XR; Zhu XF; Hong MH; Liu Q
    Carcinogenesis; 2008 Oct; 29(10):1930-7. PubMed ID: 18667445
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of Aurora-A results in increased cell death in 3-dimensional culture microenvironment, reduced migration and is associated with enhanced radiosensitivity in human nasopharyngeal carcinoma.
    Wan XB; Fan XJ; Chen MY; Xu J; Long ZJ; Hua YJ; Ji H; Liu L; Hong MH; Zeng YX; Liu Q
    Cancer Biol Ther; 2009 Aug; 8(15):1500-6. PubMed ID: 19502819
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism.
    Kelly KR; Nawrocki ST; Espitia CM; Zhang M; Yang JJ; Padmanabhan S; Ecsedy J; Giles FJ; Carew JS
    Int J Cancer; 2012 Dec; 131(11):2693-703. PubMed ID: 22488249
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia.
    Kojima K; Konopleva M; Tsao T; Nakakuma H; Andreeff M
    Blood; 2008 Oct; 112(7):2886-95. PubMed ID: 18633130
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.
    Kim JS; Eom JI; Cheong JW; Choi AJ; Lee JK; Yang WI; Min YH
    Clin Cancer Res; 2007 Feb; 13(3):1019-28. PubMed ID: 17289898
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells.
    Rao J; Xu DR; Zheng FM; Long ZJ; Huang SS; Wu X; Zhou WH; Huang RW; Liu Q
    J Transl Med; 2011 May; 9():71. PubMed ID: 21595920
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival.
    Yao JE; Yan M; Guan Z; Pan CB; Xia LP; Li CX; Wang LH; Long ZJ; Zhao Y; Li MW; Zheng FM; Xu J; Lin DJ; Liu Q
    Mol Cancer; 2009 Nov; 8():95. PubMed ID: 19891769
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Vincristine potentiates the anti-proliferative effect of an aurora kinase inhibitor, VE-465, in myeloid leukemia cells.
    Yoshida K; Nagai T; Ohmine K; Uesawa M; Sripayap P; Ishida Y; Ozawa K
    Biochem Pharmacol; 2011 Dec; 82(12):1884-90. PubMed ID: 21971583
    [TBL] [Abstract][Full Text] [Related]  

  • 15. VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.
    Tyler RK; Shpiro N; Marquez R; Eyers PA
    Cell Cycle; 2007 Nov; 6(22):2846-54. PubMed ID: 18032922
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
    Zeng Z; Samudio IJ; Zhang W; Estrov Z; Pelicano H; Harris D; Frolova O; Hail N; Chen W; Kornblau SM; Huang P; Lu Y; Mills GB; Andreeff M; Konopleva M
    Cancer Res; 2006 Apr; 66(7):3737-46. PubMed ID: 16585200
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dawn of Aurora kinase inhibitors as anticancer drugs.
    Doggrell SA
    Expert Opin Investig Drugs; 2004 Sep; 13(9):1199-201. PubMed ID: 15330750
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe.
    Cheong JW; Jung HI; Eom JI; Kim SJ; Jeung HK; Min YH
    Cancer Lett; 2010 Nov; 297(2):171-81. PubMed ID: 20547440
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes.
    Payton M; Cheung HK; Ninniri MSS; Marinaccio C; Wayne WC; Hanestad K; Crispino JD; Juan G; Coxon A
    Mol Cancer Ther; 2018 Dec; 17(12):2575-2585. PubMed ID: 30266802
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets.
    de Paula Careta F; Gobessi S; Panepucci RA; Bojnik E; Morato de Oliveira F; Mazza Matos D; Falcão RP; Laurenti L; Zago MA; Efremov DG
    Haematologica; 2012 Aug; 97(8):1246-54. PubMed ID: 22331265
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.