BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

82 related articles for article (PubMed ID: 18178434)

  • 1. Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization.
    Colabufo NA; Abate C; Contino M; Inglese C; Ferorelli S; Berardi F; Perrone R
    Bioorg Med Chem Lett; 2008 Mar; 18(6):2183-7. PubMed ID: 18178434
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer.
    Abate C; Elenewski J; Niso M; Berardi F; Colabufo NA; Azzariti A; Perrone R; Glennon RA
    ChemMedChem; 2010 Feb; 5(2):268-73. PubMed ID: 20077462
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells.
    Cassano G; Gasparre G; Contino M; Niso M; Berardi F; Perrone R; Colabufo NA
    Cell Calcium; 2006 Jul; 40(1):23-8. PubMed ID: 16687172
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET.
    Colabufo NA; Berardi F; Contino M; Fazio F; Matarrese M; Moresco RM; Niso M; Perrone R; Tortorella V
    J Pharm Pharmacol; 2005 Nov; 57(11):1453-9. PubMed ID: 16259778
    [TBL] [Abstract][Full Text] [Related]  

  • 5. F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells.
    Cassano G; Gasparre G; Niso M; Contino M; Scalera V; Colabufo NA
    Cell Calcium; 2009 Apr; 45(4):340-5. PubMed ID: 19187959
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
    Berardi F; Abate C; Ferorelli S; Uricchio V; Colabufo NA; Niso M; Perrone R
    J Med Chem; 2009 Dec; 52(23):7817-28. PubMed ID: 19842660
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.
    Abate C; Hornick JR; Spitzer D; Hawkins WG; Niso M; Perrone R; Berardi F
    J Med Chem; 2011 Aug; 54(16):5858-67. PubMed ID: 21744858
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers.
    Abate C; Niso M; Lacivita E; Mosier PD; Toscano A; Perrone R
    J Med Chem; 2011 Feb; 54(4):1022-32. PubMed ID: 21229979
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.
    Mésangeau C; Narayanan S; Green AM; Shaikh J; Kaushal N; Viard E; Xu YT; Fishback JA; Poupaert JH; Matsumoto RR; McCurdy CR
    J Med Chem; 2008 Mar; 51(5):1482-6. PubMed ID: 18278854
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies.
    Barrondo S; Sallés J
    Neuropharmacology; 2009 Feb; 56(2):455-62. PubMed ID: 18951909
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer.
    Azzariti A; Colabufo NA; Berardi F; Porcelli L; Niso M; Simone GM; Perrone R; Paradiso A
    Mol Cancer Ther; 2006 Jul; 5(7):1807-16. PubMed ID: 16891467
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
    Venable JD; Cai H; Chai W; Dvorak CA; Grice CA; Jablonowski JA; Shah CR; Kwok AK; Ly KS; Pio B; Wei J; Desai PJ; Jiang W; Nguyen S; Ling P; Wilson SJ; Dunford PJ; Thurmond RL; Lovenberg TW; Karlsson L; Carruthers NI; Edwards JP
    J Med Chem; 2005 Dec; 48(26):8289-98. PubMed ID: 16366610
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies.
    Ferorelli S; Abate C; Colabufo NA; Niso M; Inglese C; Berardi F; Perrone R
    J Med Chem; 2007 Sep; 50(19):4648-55. PubMed ID: 17713896
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor.
    Berardi F; Ferorelli S; Abate C; Pedone MP; Colabufo NA; Contino M; Perrone R
    J Med Chem; 2005 Dec; 48(26):8237-44. PubMed ID: 16366605
    [TBL] [Abstract][Full Text] [Related]  

  • 15. [3H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: a novel sigma-2 receptor probe.
    Xu J; Tu Z; Jones LA; Vangveravong S; Wheeler KT; Mach RH
    Eur J Pharmacol; 2005 Nov; 525(1-3):8-17. PubMed ID: 16289030
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors.
    Nahas RI; Lever JR; Lever SZ
    Bioorg Med Chem; 2008 Jan; 16(2):755-61. PubMed ID: 18029187
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
    Berardi F; Abate C; Ferorelli S; de Robertis AF; Leopoldo M; Colabufo NA; Niso M; Perrone R
    J Med Chem; 2008 Dec; 51(23):7523-31. PubMed ID: 19053780
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site.
    Zampieri D; Grazia Mamolo M; Laurini E; Zanette C; Florio C; Collina S; Rossi D; Azzolina O; Vio L
    Eur J Med Chem; 2009 Jan; 44(1):124-30. PubMed ID: 18440098
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification and characterization of pseudoirreversible nonpeptide antagonists of the neuropeptide Y Y5 receptor and development of a novel Y5-selective radioligand.
    Mullins D; Adham N; Hesk D; Wu Y; Kelly J; Huang Y; Guzzi M; Zhang X; McCombie S; Stamford A; Parker E
    Eur J Pharmacol; 2008 Dec; 601(1-3):1-7. PubMed ID: 18976648
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacological and metabolic characterisation of the potent sigma1 receptor ligand 1'-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine].
    Wiese C; Grosse Maestrup E; Schepmann D; Vela JM; Holenz J; Buschmann H; Wünsch B
    J Pharm Pharmacol; 2009 May; 61(5):631-40. PubMed ID: 19406002
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.