These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

401 related articles for article (PubMed ID: 18178963)

  • 1. Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele.
    Yang SH; Qiao X; Farber E; Chang SY; Fong LG; Young SG
    J Biol Chem; 2008 Mar; 283(11):7094-9. PubMed ID: 18178963
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome.
    Davies BS; Yang SH; Farber E; Lee R; Buck SB; Andres DA; Spielmann HP; Agnew BJ; Tamanoi F; Fong LG; Young SG
    J Lipid Res; 2009 Jan; 50(1):126-34. PubMed ID: 18757838
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.
    Yang SH; Chang SY; Ren S; Wang Y; Andres DA; Spielmann HP; Fong LG; Young SG
    Hum Mol Genet; 2011 Feb; 20(3):436-44. PubMed ID: 21088111
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Prelamin A and lamin A appear to be dispensable in the nuclear lamina.
    Fong LG; Ng JK; Lammerding J; Vickers TA; Meta M; Coté N; Gavino B; Qiao X; Chang SY; Young SR; Yang SH; Stewart CL; Lee RT; Bennett CF; Bergo MO; Young SG
    J Clin Invest; 2006 Mar; 116(3):743-52. PubMed ID: 16511604
    [TBL] [Abstract][Full Text] [Related]  

  • 5. New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome.
    Jung HJ; Tu Y; Yang SH; Tatar A; Nobumori C; Wu D; Young SG; Fong LG
    Hum Mol Genet; 2014 Mar; 23(6):1506-15. PubMed ID: 24203701
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.
    Moulson CL; Fong LG; Gardner JM; Farber EA; Go G; Passariello A; Grange DK; Young SG; Miner JH
    Hum Mutat; 2007 Sep; 28(9):882-9. PubMed ID: 17469202
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.
    Rivera-Torres J; Acín-Perez R; Cabezas-Sánchez P; Osorio FG; Gonzalez-Gómez C; Megias D; Cámara C; López-Otín C; Enríquez JA; Luque-García JL; Andrés V
    J Proteomics; 2013 Oct; 91():466-77. PubMed ID: 23969228
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.
    Yang SH; Bergo MO; Toth JI; Qiao X; Hu Y; Sandoval S; Meta M; Bendale P; Gelb MH; Young SG; Fong LG
    Proc Natl Acad Sci U S A; 2005 Jul; 102(29):10291-6. PubMed ID: 16014412
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice.
    Fong LG; Ng JK; Meta M; Coté N; Yang SH; Stewart CL; Sullivan T; Burghardt A; Majumdar S; Reue K; Bergo MO; Young SG
    Proc Natl Acad Sci U S A; 2004 Dec; 101(52):18111-6. PubMed ID: 15608054
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.
    Yang SH; Andres DA; Spielmann HP; Young SG; Fong LG
    J Clin Invest; 2008 Oct; 118(10):3291-300. PubMed ID: 18769635
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.
    Coffinier C; Jung HJ; Li Z; Nobumori C; Yun UJ; Farber EA; Davies BS; Weinstein MM; Yang SH; Lammerding J; Farahani JN; Bentolila LA; Fong LG; Young SG
    J Biol Chem; 2010 Jul; 285(27):20818-26. PubMed ID: 20439468
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Neonatal progeria: increased ratio of progerin to lamin A leads to progeria of the newborn.
    Reunert J; Wentzell R; Walter M; Jakubiczka S; Zenker M; Brune T; Rust S; Marquardt T
    Eur J Hum Genet; 2012 Sep; 20(9):933-7. PubMed ID: 22419169
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin.
    Wang Y; Panteleyev AA; Owens DM; Djabali K; Stewart CL; Worman HJ
    Hum Mol Genet; 2008 Aug; 17(15):2357-69. PubMed ID: 18442998
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome.
    Hamczyk MR; Villa-Bellosta R; Gonzalo P; Andrés-Manzano MJ; Nogales P; Bentzon JF; López-Otín C; Andrés V
    Circulation; 2018 Jul; 138(3):266-282. PubMed ID: 29490993
    [TBL] [Abstract][Full Text] [Related]  

  • 15. All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.
    Pellegrini C; Columbaro M; Capanni C; D'Apice MR; Cavallo C; Murdocca M; Lattanzi G; Squarzoni S
    Oncotarget; 2015 Oct; 6(30):29914-28. PubMed ID: 26359359
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A conserved splicing mechanism of the LMNA gene controls premature aging.
    Lopez-Mejia IC; Vautrot V; De Toledo M; Behm-Ansmant I; Bourgeois CF; Navarro CL; Osorio FG; Freije JM; Stévenin J; De Sandre-Giovannoli A; Lopez-Otin C; Lévy N; Branlant C; Tazi J
    Hum Mol Genet; 2011 Dec; 20(23):4540-55. PubMed ID: 21875900
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides.
    Fong LG; Vickers TA; Farber EA; Choi C; Yun UJ; Hu Y; Yang SH; Coffinier C; Lee R; Yin L; Davies BS; Andres DA; Spielmann HP; Bennett CF; Young SG
    Hum Mol Genet; 2009 Jul; 18(13):2462-71. PubMed ID: 19376814
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.
    Glynn MW; Glover TW
    Hum Mol Genet; 2005 Oct; 14(20):2959-69. PubMed ID: 16126733
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hutchinson-Gilford progeria syndrome through the lens of transcription.
    Prokocimer M; Barkan R; Gruenbaum Y
    Aging Cell; 2013 Aug; 12(4):533-43. PubMed ID: 23496208
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Investigation of age-related changes in LMNA splicing and expression of progerin in human skeletal muscles.
    Luo YB; Mitrpant C; Johnsen RD; Fabian VA; Fletcher S; Mastaglia FL; Wilton SD
    Int J Clin Exp Pathol; 2013; 6(12):2778-86. PubMed ID: 24294364
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.