218 related articles for article (PubMed ID: 18182389)
1. Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.
Kaden D; Munter LM; Joshi M; Treiber C; Weise C; Bethge T; Voigt P; Schaefer M; Beyermann M; Reif B; Multhaup G
J Biol Chem; 2008 Mar; 283(11):7271-9. PubMed ID: 18182389
[TBL] [Abstract][Full Text] [Related]
2. Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
Richter L; Munter LM; Ness J; Hildebrand PW; Dasari M; Unterreitmeier S; Bulic B; Beyermann M; Gust R; Reif B; Weggen S; Langosch D; Multhaup G
Proc Natl Acad Sci U S A; 2010 Aug; 107(33):14597-602. PubMed ID: 20679249
[TBL] [Abstract][Full Text] [Related]
3. Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.
Huang XP; Chang WP; Koelsch G; Turner RT; Lupu F; Tang J
J Biol Chem; 2004 Sep; 279(36):37886-94. PubMed ID: 15197182
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein.
Carey RM; Balcz BA; Lopez-Coviella I; Slack BE
BMC Cell Biol; 2005 Aug; 6():30. PubMed ID: 16095541
[TBL] [Abstract][Full Text] [Related]
5. Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?
Beel AJ; Mobley CK; Kim HJ; Tian F; Hadziselimovic A; Jap B; Prestegard JH; Sanders CR
Biochemistry; 2008 Sep; 47(36):9428-46. PubMed ID: 18702528
[TBL] [Abstract][Full Text] [Related]
6. Amyloid precursor protein and BACE function as oligomers.
Multhaup G
Neurodegener Dis; 2006; 3(4-5):270-4. PubMed ID: 17047367
[TBL] [Abstract][Full Text] [Related]
7. Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites.
Yan Y; Xu TH; Harikumar KG; Miller LJ; Melcher K; Xu HE
J Biol Chem; 2017 Sep; 292(38):15826-15837. PubMed ID: 28790170
[TBL] [Abstract][Full Text] [Related]
8. The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
Kinoshita A; Whelan CM; Berezovska O; Hyman BT
J Biol Chem; 2002 Aug; 277(32):28530-6. PubMed ID: 12032152
[TBL] [Abstract][Full Text] [Related]
9. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
Gandhi S; Refolo LM; Sambamurti K
J Mol Neurosci; 2004; 24(1):137-43. PubMed ID: 15314262
[TBL] [Abstract][Full Text] [Related]
10. Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
Spoelgen R; von Arnim CA; Thomas AV; Peltan ID; Koker M; Deng A; Irizarry MC; Andersen OM; Willnow TE; Hyman BT
J Neurosci; 2006 Jan; 26(2):418-28. PubMed ID: 16407538
[TBL] [Abstract][Full Text] [Related]
11. Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein.
Song Y; Hustedt EJ; Brandon S; Sanders CR
Biochemistry; 2013 Jul; 52(30):5051-64. PubMed ID: 23865807
[TBL] [Abstract][Full Text] [Related]
12. GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.
von Arnim CA; Spoelgen R; Peltan ID; Deng M; Courchesne S; Koker M; Matsui T; Kowa H; Lichtenthaler SF; Irizarry MC; Hyman BT
J Neurosci; 2006 Sep; 26(39):9913-22. PubMed ID: 17005855
[TBL] [Abstract][Full Text] [Related]
13. Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.
Neumann S; Schöbel S; Jäger S; Trautwein A; Haass C; Pietrzik CU; Lichtenthaler SF
J Biol Chem; 2006 Mar; 281(11):7583-94. PubMed ID: 16344553
[TBL] [Abstract][Full Text] [Related]
14. Palmitoylated APP Forms Dimers, Cleaved by BACE1.
Bhattacharyya R; Fenn RH; Barren C; Tanzi RE; Kovacs DM
PLoS One; 2016; 11(11):e0166400. PubMed ID: 27875558
[TBL] [Abstract][Full Text] [Related]
15. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.
Lammich S; Kojro E; Postina R; Gilbert S; Pfeiffer R; Jasionowski M; Haass C; Fahrenholz F
Proc Natl Acad Sci U S A; 1999 Mar; 96(7):3922-7. PubMed ID: 10097139
[TBL] [Abstract][Full Text] [Related]
16. Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.
Scheuermann S; Hambsch B; Hesse L; Stumm J; Schmidt C; Beher D; Bayer TA; Beyreuther K; Multhaup G
J Biol Chem; 2001 Sep; 276(36):33923-9. PubMed ID: 11438549
[TBL] [Abstract][Full Text] [Related]
17. X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
King GD; Cherian K; Turner RS
J Neurochem; 2004 Feb; 88(4):971-82. PubMed ID: 14756819
[TBL] [Abstract][Full Text] [Related]
18. Matriptase processing of APLP1 ectodomain alters its homodimerization.
Lanchec E; Désilets A; Béliveau F; Fontaine-Carbonneau C; Laniel A; Leduc R; Lavoie C
Sci Rep; 2020 Jun; 10(1):10091. PubMed ID: 32572095
[TBL] [Abstract][Full Text] [Related]
19. The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators.
Botev A; Munter LM; Wenzel R; Richter L; Althoff V; Ismer J; Gerling U; Weise C; Koksch B; Hildebrand PW; Bittl R; Multhaup G
Biochemistry; 2011 Feb; 50(5):828-35. PubMed ID: 21186781
[TBL] [Abstract][Full Text] [Related]
20. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
