131 related articles for article (PubMed ID: 18194834)
1. A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: inhibition of NF-kappaB?
Axon A; Cowie DE; Mann DA; Wright MC
Toxicology; 2008 Apr; 246(1):40-4. PubMed ID: 18194834
[TBL] [Abstract][Full Text] [Related]
2. The PXR is a drug target for chronic inflammatory liver disease.
Wallace K; Cowie DE; Konstantinou DK; Hill SJ; Tjelle TE; Axon A; Koruth M; White SA; Carlsen H; Mann DA; Wright MC
J Steroid Biochem Mol Biol; 2010 May; 120(2-3):137-48. PubMed ID: 20416375
[TBL] [Abstract][Full Text] [Related]
3. Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes.
González R; Collado JA; Nell S; Briceño J; Tamayo MJ; Fraga E; Bernardos A; López-Cillero P; Pascussi JM; Rufián S; Vilarem MJ; De la Mata M; Brigelius-Flohe R; Maurel P; Muntané J
Free Radic Biol Med; 2007 Nov; 43(10):1439-52. PubMed ID: 17936189
[TBL] [Abstract][Full Text] [Related]
4. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.
Marek CJ; Tucker SJ; Konstantinou DK; Elrick LJ; Haefner D; Sigalas C; Murray GI; Goodwin B; Wright MC
Biochem J; 2005 May; 387(Pt 3):601-8. PubMed ID: 15595924
[TBL] [Abstract][Full Text] [Related]
5. Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway.
Dou W; Zhang J; Zhang E; Sun A; Ding L; Chou G; Wang Z; Mani S
J Pharmacol Exp Ther; 2013 Jun; 345(3):473-82. PubMed ID: 23536316
[TBL] [Abstract][Full Text] [Related]
6. Patchouli alcohol activates PXR and suppresses the NF-κB-mediated intestinal inflammatory.
Zhang G; Liu M; Song M; Wang J; Cai J; Lin C; Li Y; Jin X; Shen C; Chen Z; Cai D; Gao Y; Zhu C; Lin C; Liu C
J Ethnopharmacol; 2020 Feb; 248():112302. PubMed ID: 31614203
[TBL] [Abstract][Full Text] [Related]
7. The impact of pregnane X receptor activation on liver fibrosis.
Wright MC
Biochem Soc Trans; 2006 Dec; 34(Pt 6):1119-23. PubMed ID: 17073765
[TBL] [Abstract][Full Text] [Related]
8. Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.
Zhou C; Tabb MM; Nelson EL; Grün F; Verma S; Sadatrafiei A; Lin M; Mallick S; Forman BM; Thummel KE; Blumberg B
J Clin Invest; 2006 Aug; 116(8):2280-2289. PubMed ID: 16841097
[TBL] [Abstract][Full Text] [Related]
9. Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.
Krausova L; Stejskalova L; Wang H; Vrzal R; Dvorak Z; Mani S; Pavek P
Biochem Pharmacol; 2011 Dec; 82(11):1771-80. PubMed ID: 21920351
[TBL] [Abstract][Full Text] [Related]
10. PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.
Okamura M; Shizu R; Abe T; Kodama S; Hosaka T; Sasaki T; Yoshinari K
Cells; 2020 Oct; 9(10):. PubMed ID: 33076328
[TBL] [Abstract][Full Text] [Related]
11. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.
Pascussi JM; Drocourt L; Fabre JM; Maurel P; Vilarem MJ
Mol Pharmacol; 2000 Aug; 58(2):361-72. PubMed ID: 10908304
[TBL] [Abstract][Full Text] [Related]
12. Pregnane X receptor-dependent and -independent effects of 2-acetylaminofluorene on cytochrome P450 3A23 expression and liver cell proliferation.
Sparfel L; Payen L; Gilot D; Sidaway J; Morel F; Guillouzo A; Fardel O
Biochem Biophys Res Commun; 2003 Jan; 300(2):278-84. PubMed ID: 12504080
[TBL] [Abstract][Full Text] [Related]
13. Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis.
Niu Y; Wu Z; Shen Q; Song J; Luo Q; You H; Shi G; Qin W
Dig Liver Dis; 2013 Dec; 45(12):1041-8. PubMed ID: 23891548
[TBL] [Abstract][Full Text] [Related]
14. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Li T; Chiang JY
Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
[TBL] [Abstract][Full Text] [Related]
15. Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation.
Cheng J; Shah YM; Ma X; Pang X; Tanaka T; Kodama T; Krausz KW; Gonzalez FJ
J Pharmacol Exp Ther; 2010 Oct; 335(1):32-41. PubMed ID: 20627999
[TBL] [Abstract][Full Text] [Related]
16. Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression.
Shah YM; Ma X; Morimura K; Kim I; Gonzalez FJ
Am J Physiol Gastrointest Liver Physiol; 2007 Apr; 292(4):G1114-22. PubMed ID: 17170021
[TBL] [Abstract][Full Text] [Related]
17. Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
Maglich JM; Stoltz CM; Goodwin B; Hawkins-Brown D; Moore JT; Kliewer SA
Mol Pharmacol; 2002 Sep; 62(3):638-46. PubMed ID: 12181440
[TBL] [Abstract][Full Text] [Related]
18. A gut feeling of the PXR, PPAR and NF-kappaB connection.
Wahli W
J Intern Med; 2008 Jun; 263(6):613-9. PubMed ID: 18479261
[TBL] [Abstract][Full Text] [Related]
19. Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.
Sane RS; Buckley DJ; Buckley AR; Nallani SC; Desai PB
Drug Metab Dispos; 2008 May; 36(5):946-54. PubMed ID: 18299335
[TBL] [Abstract][Full Text] [Related]
20. Involvement of Nuclear Factor
Abualsunun WA; Piquette-Miller M
Drug Metab Dispos; 2017 Oct; 45(10):1077-1083. PubMed ID: 28778997
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]