BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

378 related articles for article (PubMed ID: 18197631)

  • 1. Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase II alpha.
    Wu X; Liang H; O'Hara KA; Yalowich JC; Hasinoff BB
    Chem Res Toxicol; 2008 Feb; 21(2):483-93. PubMed ID: 18197631
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Biochemical and proteomics approaches to characterize topoisomerase IIalpha cysteines and DNA as targets responsible for cisplatin-induced inhibition of topoisomerase IIalpha.
    Hasinoff BB; Wu X; Krokhin OV; Ens W; Standing KG; Nitiss JL; Sivaram T; Giorgianni A; Yang S; Jiang Y; Yalowich JC
    Mol Pharmacol; 2005 Mar; 67(3):937-47. PubMed ID: 15602006
    [TBL] [Abstract][Full Text] [Related]  

  • 3. NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors.
    Onda T; Toyoda E; Miyazaki O; Seno C; Kagaya S; Okamoto K; Nishikawa K
    Cancer Lett; 2008 Jan; 259(1):99-110. PubMed ID: 17998154
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Sensitization effect of thimerosal is mediated in vitro via reactive oxygen species and calcium signaling.
    Migdal C; Foggia L; Tailhardat M; Courtellemont P; Haftek M; Serres M
    Toxicology; 2010; 274(1-3):1-9. PubMed ID: 20457211
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A three-dimensional quantitative structure-activity relationship study of the inhibition of the ATPase activity and the strand passing catalytic activity of topoisomerase IIalpha by substituted purine analogs.
    Jensen LH; Liang H; Shoemaker R; Grauslund M; Sehested M; Hasinoff BB
    Mol Pharmacol; 2006 Nov; 70(5):1503-13. PubMed ID: 16880287
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.
    Jensen LH; Thougaard AV; Grauslund M; Søkilde B; Carstensen EV; Dvinge HK; Scudiero DA; Jensen PB; Shoemaker RH; Sehested M
    Cancer Res; 2005 Aug; 65(16):7470-7. PubMed ID: 16103101
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors.
    Liang H; Wu X; Yalowich JC; Hasinoff BB
    Mol Pharmacol; 2008 Mar; 73(3):686-96. PubMed ID: 18045852
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Property of thimerosal-induced decrease in cellular content of glutathione in rat thymocytes: a flow cytometric study with 5-chloromethylfluorescein diacetate.
    Ueha-Ishibashi T; Tatsuishi T; Iwase K; Nakao H; Umebayashi C; Nishizaki Y; Nishimura Y; Oyama Y; Hirama S; Okano Y
    Toxicol In Vitro; 2004 Oct; 18(5):563-9. PubMed ID: 15251173
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects.
    Hasinoff BB; Wu X; Yalowich JC; Goodfellow V; Laufer RS; Adedayo O; Dmitrienko GI
    Anticancer Drugs; 2006 Aug; 17(7):825-37. PubMed ID: 16926632
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II.
    Hasinoff BB; Wu X; Begleiter A; Guziec LJ; Guziec F; Giorgianni A; Yang S; Jiang Y; Yalowich JC
    Cancer Chemother Pharmacol; 2006 Jan; 57(2):221-33. PubMed ID: 16010589
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Thiol involvement in the inhibition of DNA repair by metals in mammalian cells.
    Snyder RD; Lachmann PJ
    Mol Toxicol; 1989; 2(2):117-28. PubMed ID: 2702302
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition.
    Cai YJ; Lu JJ; Zhu H; Xie H; Huang M; Lin LP; Zhang XW; Ding J
    Free Radic Biol Med; 2008 Sep; 45(5):627-35. PubMed ID: 18582559
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Anticancer activity of botanical alkyl hydroquinones attributed to topoisomerase II poisoning.
    Huang CP; Fang WH; Lin LI; Chiou RY; Kan LS; Chi NH; Chen YR; Lin TY; Lin SB
    Toxicol Appl Pharmacol; 2008 Mar; 227(3):331-8. PubMed ID: 18164362
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sodium salicylate is a novel catalytic inhibitor of human DNA topoisomerase II alpha.
    Bau JT; Kurz EU
    Biochem Pharmacol; 2011 Feb; 81(3):345-54. PubMed ID: 20959117
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of the action of the topoisomerase II poison amsacrine by simple aniline derivatives: evidence for drug-protein interactions.
    Finlay GJ; Atwell GJ; Baguley BC
    Oncol Res; 1999; 11(6):249-54. PubMed ID: 10691026
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Low molecular weight thiols reduce thimerosal neurotoxicity in vitro: modulation by proteins.
    Zieminska E; Toczylowska B; Stafiej A; Lazarewicz JW
    Toxicology; 2010 Oct; 276(3):154-63. PubMed ID: 20696200
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lycobetaine acts as a selective topoisomerase II beta poison and inhibits the growth of human tumour cells.
    Barthelmes HU; Niederberger E; Roth T; Schulte K; Tang WC; Boege F; Fiebig HH; Eisenbrand G; Marko D
    Br J Cancer; 2001 Nov; 85(10):1585-91. PubMed ID: 11720449
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform.
    Fehr M; Pahlke G; Fritz J; Christensen MO; Boege F; Altemöller M; Podlech J; Marko D
    Mol Nutr Food Res; 2009 Apr; 53(4):441-51. PubMed ID: 18727009
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes.
    Kondapi AK; Satyanarayana N; Saikrishna AD
    Arch Biochem Biophys; 2006 Jun; 450(2):123-32. PubMed ID: 16712776
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ebselen induces apoptosis in HepG(2) cells through rapid depletion of intracellular thiols.
    Yang CF; Shen HM; Ong CN
    Arch Biochem Biophys; 2000 Feb; 374(2):142-52. PubMed ID: 10666292
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.