BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 18216394)

  • 21. Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity.
    Li P; Zhang M; Peach ML; Zhang X; Liu H; Nicklaus M; Yang D; Roller PP
    Biochem Biophys Res Commun; 2003 Aug; 307(4):1038-44. PubMed ID: 12878216
    [TBL] [Abstract][Full Text] [Related]  

  • 22. N-terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding.
    Burke TR; Yao ZJ; Gao Y; Wu JX; Zhu X; Luo JH; Guo R; Yang D
    Bioorg Med Chem; 2001 Jun; 9(6):1439-45. PubMed ID: 11408162
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.
    Oishi S; Karki RG; Kang SU; Wang X; Worthy KM; Bindu LK; Nicklaus MC; Fisher RJ; Burke TR
    J Med Chem; 2005 Feb; 48(3):764-72. PubMed ID: 15689160
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC.
    De Vet EC; Aguado B; Campbell RD
    Biochem J; 2003 Oct; 375(Pt 1):207-13. PubMed ID: 12852788
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.
    Shi ZD; Karki RG; Oishi S; Worthy KM; Bindu LK; Dharmawardana PG; Nicklaus MC; Bottaro DP; Fisher RJ; Burke TR
    Bioorg Med Chem Lett; 2005 Mar; 15(5):1385-8. PubMed ID: 15713392
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine.
    Long YQ; Xue T; Song YL; Liu ZL; Huang SX; Yu Q
    J Med Chem; 2008 Oct; 51(20):6371-80. PubMed ID: 18821748
    [TBL] [Abstract][Full Text] [Related]  

  • 27. The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.
    Lewitzky M; Kardinal C; Gehring NH; Schmidt EK; Konkol B; Eulitz M; Birchmeier W; Schaeper U; Feller SM
    Oncogene; 2001 Mar; 20(9):1052-62. PubMed ID: 11314042
    [TBL] [Abstract][Full Text] [Related]  

  • 28. A fluorescence polarization based Src-SH2 binding assay.
    Lynch BA; Loiacono KA; Tiong CL; Adams SE; MacNeil IA
    Anal Biochem; 1997 Apr; 247(1):77-82. PubMed ID: 9126374
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Simultaneous assay of Src SH3 and SH2 domain binding using different wavelength fluorescence polarization probes.
    Lynch BA; Minor C; Loiacono KA; van Schravendijk MR; Ram MK; Sundaramoorthi R; Adams SE; Phillips T; Holt D; Rickles RJ; MacNeil IA
    Anal Biochem; 1999 Nov; 275(1):62-73. PubMed ID: 10542110
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2.
    Kasus-Jacobi A; Béréziat V; Perdereau D; Girard J; Burnol AF
    Oncogene; 2000 Apr; 19(16):2052-9. PubMed ID: 10803466
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains.
    de Mol NJ; Dekker FJ; Broutin I; Fischer MJ; Liskamp RM
    J Med Chem; 2005 Feb; 48(3):753-63. PubMed ID: 15689159
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structural requirements for Tyr in the consensus sequence Y-E-N of a novel nonphosphorylated inhibitor to the Grb2-SH2 domain.
    Long YQ; Yao ZJ; Voigt JH; Lung FD; Luo JH; Burke TR; King CR; Yang D; Roller PP
    Biochem Biophys Res Commun; 1999 Nov; 264(3):902-8. PubMed ID: 10544028
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Functional implications of the conformational switch in AICD peptide upon binding to Grb2-SH2 domain.
    Das S; Raychaudhuri M; Sen U; Mukhopadhyay D
    J Mol Biol; 2011 Nov; 414(2):217-30. PubMed ID: 22001015
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.
    Ogura K; Tsuchiya S; Terasawa H; Yuzawa S; Hatanaka H; Mandiyan V; Schlessinger J; Inagaki F
    J Mol Biol; 1999 Jun; 289(3):439-45. PubMed ID: 10356320
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Alternative mode of binding to phosphotyrosyl peptides by Src homology-2 domains.
    Qin C; Wavreille AS; Pei D
    Biochemistry; 2005 Sep; 44(36):12196-202. PubMed ID: 16142918
    [TBL] [Abstract][Full Text] [Related]  

  • 36. The intertwining of structure and function: proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation.
    Pias S; Peterson TA; Johnson DL; Lyons BA
    Crit Rev Immunol; 2010; 30(3):299-304. PubMed ID: 20370637
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of 3-aminobenzyloxycarbonyl as an N-terminal group conferring high affinity to the minimal phosphopeptide sequence recognized by the Grb2-SH2 domain.
    Furet P; Gay B; García-Echeverría C; Rahuel J; Fretz H; Schoepfer J; Caravatti G
    J Med Chem; 1997 Oct; 40(22):3551-6. PubMed ID: 9357522
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis.
    Tanaka S; Pero SC; Taguchi K; Shimada M; Mori M; Krag DN; Arii S
    J Natl Cancer Inst; 2006 Apr; 98(7):491-8. PubMed ID: 16595785
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic.
    Gao Y; Luo J; Yao ZJ; Guo R; Zou H; Kelley J; Voigt JH; Yang D; Burke TR
    J Med Chem; 2000 Mar; 43(5):911-20. PubMed ID: 10715157
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform.
    Kang SU; Shi ZD; Worthy KM; Bindu LK; Dharmawardana PG; Choyke SJ; Bottaro DP; Fisher RJ; Burke TR
    J Med Chem; 2005 Jun; 48(12):3945-8. PubMed ID: 15943469
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.