184 related articles for article (PubMed ID: 18218633)
1. Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage.
Jamburuthugoda VK; Santos-Velazquez JM; Skasko M; Operario DJ; Purohit V; Chugh P; Szymanski EA; Wedekind JE; Bambara RA; Kim B
J Biol Chem; 2008 Apr; 283(14):9206-16. PubMed ID: 18218633
[TBL] [Abstract][Full Text] [Related]
2. Mechanistic interplay among the M184I HIV-1 reverse transcriptase mutant, the central polypurine tract, cellular dNTP concentrations and drug sensitivity.
Van Cor-Hosmer SK; Daddacha W; Kim B
Virology; 2010 Oct; 406(2):253-60. PubMed ID: 20701944
[TBL] [Abstract][Full Text] [Related]
3. Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect.
Gao L; Hanson MN; Balakrishnan M; Boyer PL; Roques BP; Hughes SH; Kim B; Bambara RA
J Biol Chem; 2008 Apr; 283(14):9196-205. PubMed ID: 18218634
[TBL] [Abstract][Full Text] [Related]
4. The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.
Gao HQ; Boyer PL; Sarafianos SG; Arnold E; Hughes SH
J Mol Biol; 2000 Jul; 300(2):403-18. PubMed ID: 10873473
[TBL] [Abstract][Full Text] [Related]
5. The influence of 3TC resistance mutation M184I on the fidelity and error specificity of human immunodeficiency virus type 1 reverse transcriptase.
Rezende LF; Drosopoulos WC; Prasad VR
Nucleic Acids Res; 1998 Jun; 26(12):3066-72. PubMed ID: 9611256
[TBL] [Abstract][Full Text] [Related]
6. Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Sarafianos SG; Das K; Clark AD; Ding J; Boyer PL; Hughes SH; Arnold E
Proc Natl Acad Sci U S A; 1999 Aug; 96(18):10027-32. PubMed ID: 10468556
[TBL] [Abstract][Full Text] [Related]
7. Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations.
Xu HT; Asahchop EL; Oliveira M; Quashie PK; Quan Y; Brenner BG; Wainberg MA
J Virol; 2011 Nov; 85(21):11300-8. PubMed ID: 21849444
[TBL] [Abstract][Full Text] [Related]
8. Subunit-selective mutational analysis and tissue culture evaluations of the interactions of the E138K and M184I mutations in HIV-1 reverse transcriptase.
Xu HT; Oliveira M; Quashie PK; McCallum M; Han Y; Quan Y; Brenner BG; Wainberg MA
J Virol; 2012 Aug; 86(16):8422-31. PubMed ID: 22623801
[TBL] [Abstract][Full Text] [Related]
9. Limiting deoxynucleoside triphosphate concentrations emphasize the processivity defect of lamivudine-resistant variants of human immunodeficiency virus type 1 reverse transcriptase.
Back NK; Berkhout B
Antimicrob Agents Chemother; 1997 Nov; 41(11):2484-91. PubMed ID: 9371354
[TBL] [Abstract][Full Text] [Related]
10. Reduced dNTP interaction of human immunodeficiency virus type 1 reverse transcriptase promotes strand transfer.
Operario DJ; Balakrishnan M; Bambara RA; Kim B
J Biol Chem; 2006 Oct; 281(43):32113-21. PubMed ID: 16926150
[TBL] [Abstract][Full Text] [Related]
11. Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.
Abram ME; Ferris AL; Das K; Quinoñes O; Shao W; Tuske S; Alvord WG; Arnold E; Hughes SH
J Virol; 2014 Jul; 88(13):7589-601. PubMed ID: 24760888
[TBL] [Abstract][Full Text] [Related]
12. Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.
Back NK; Nijhuis M; Keulen W; Boucher CA; Oude Essink BO; van Kuilenburg AB; van Gennip AH; Berkhout B
EMBO J; 1996 Aug; 15(15):4040-9. PubMed ID: 8670908
[TBL] [Abstract][Full Text] [Related]
13. Interaction of reverse transcriptase (RT) mutations conferring resistance to lamivudine and etravirine: effects on fitness and RT activity of human immunodeficiency virus type 1.
Hu Z; Kuritzkes DR
J Virol; 2011 Nov; 85(21):11309-14. PubMed ID: 21849432
[TBL] [Abstract][Full Text] [Related]
14. Biochemical mechanism of HIV-1 resistance to rilpivirine.
Singh K; Marchand B; Rai DK; Sharma B; Michailidis E; Ryan EM; Matzek KB; Leslie MD; Hagedorn AN; Li Z; Norden PR; Hachiya A; Parniak MA; Xu HT; Wainberg MA; Sarafianos SG
J Biol Chem; 2012 Nov; 287(45):38110-23. PubMed ID: 22955279
[TBL] [Abstract][Full Text] [Related]
15. Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors.
Xu HT; Colby-Germinario SP; Oliveira M; Rajotte D; Bethell R; Wainberg MA
Antimicrob Agents Chemother; 2014 Aug; 58(8):4515-26. PubMed ID: 24867966
[TBL] [Abstract][Full Text] [Related]
16. A role for dNTP binding of human immunodeficiency virus type 1 reverse transcriptase in viral mutagenesis.
Weiss KK; Chen R; Skasko M; Reynolds HM; Lee K; Bambara RA; Mansky LM; Kim B
Biochemistry; 2004 Apr; 43(15):4490-500. PubMed ID: 15078095
[TBL] [Abstract][Full Text] [Related]
17. M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA.
Oliveira M; Brenner BG; Xu H; Ibanescu RI; Mesplède T; Wainberg MA
J Antimicrob Chemother; 2017 Nov; 72(11):3008-3011. PubMed ID: 28961903
[TBL] [Abstract][Full Text] [Related]
18. Modification of human immunodeficiency virus type 1 reverse transcriptase to target cells with elevated cellular dNTP concentrations.
Jamburuthugoda VK; Chugh P; Kim B
J Biol Chem; 2006 May; 281(19):13388-13395. PubMed ID: 16497663
[TBL] [Abstract][Full Text] [Related]
19. Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase.
Diamond TL; Roshal M; Jamburuthugoda VK; Reynolds HM; Merriam AR; Lee KY; Balakrishnan M; Bambara RA; Planelles V; Dewhurst S; Kim B
J Biol Chem; 2004 Dec; 279(49):51545-53. PubMed ID: 15452123
[TBL] [Abstract][Full Text] [Related]
20. Effect of ribonucleotides embedded in a DNA template on HIV-1 reverse transcription kinetics and fidelity.
Daddacha W; Noble E; Nguyen LA; Kennedy EM; Kim B
J Biol Chem; 2013 May; 288(18):12522-32. PubMed ID: 23479739
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
