BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

216 related articles for article (PubMed ID: 18218728)

  • 1. The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.
    Mizutori Y; Chen CR; McLachlan SM; Rapoport B
    Mol Endocrinol; 2008 May; 22(5):1171-82. PubMed ID: 18218728
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activation.
    Chen CR; Salazar LM; McLachlan SM; Rapoport B
    Endocrinology; 2012 Oct; 153(10):5058-67. PubMed ID: 23002040
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation.
    Chen CR; McLachlan SM; Rapoport B
    Endocrinology; 2010 Apr; 151(4):1940-7. PubMed ID: 20181794
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation.
    Mueller S; Kleinau G; Jaeschke H; Paschke R; Krause G
    J Biol Chem; 2008 Jun; 283(26):18048-55. PubMed ID: 18441013
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Defining structural and functional dimensions of the extracellular thyrotropin receptor region.
    Kleinau G; Mueller S; Jaeschke H; Grzesik P; Neumann S; Diehl A; Paschke R; Krause G
    J Biol Chem; 2011 Jun; 286(25):22622-31. PubMed ID: 21525003
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological function.
    Hamidi S; Chen CR; Mizutori-Sasai Y; McLachlan SM; Rapoport B
    Mol Endocrinol; 2011 Jan; 25(1):184-94. PubMed ID: 21106880
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The hinge region of the TSH receptor stabilizes ligand binding and determines different signaling profiles of human and bovine TSH.
    Jaeschke H; Schaarschmidt J; Günther R; Mueller S
    Endocrinology; 2011 Oct; 152(10):3986-96. PubMed ID: 21846801
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain.
    Chen CR; McLachlan SM; Rapoport B
    Endocrinology; 2009 Jul; 150(7):3401-8. PubMed ID: 19299457
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.
    Krause G; Kreuchwig A; Kleinau G
    PLoS One; 2012; 7(12):e52920. PubMed ID: 23300822
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.
    Schaarschmidt J; Huth S; Meier R; Paschke R; Jaeschke H
    PLoS One; 2014; 9(10):e111570. PubMed ID: 25340405
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure.
    Hamidi S; Chen CR; McLachlan SM; Rapoport B
    Thyroid; 2011 Sep; 21(9):1013-20. PubMed ID: 21834684
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.
    Mueller S; Kleinau G; Szkudlinski MW; Jaeschke H; Krause G; Paschke R
    J Biol Chem; 2009 Jun; 284(24):16317-16324. PubMed ID: 19386596
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain.
    Marcinkowski P; Kreuchwig A; Mendieta S; Hoyer I; Witte F; Furkert J; Rutz C; Lentz D; Krause G; Schülein R
    Mol Pharmacol; 2019 Oct; 96(4):452-462. PubMed ID: 31399504
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antibody protection reveals extended epitopes on the human TSH receptor.
    Latif R; Teixeira A; Michalek K; Ali MR; Schlesinger M; Baliram R; Morshed SA; Davies TF
    PLoS One; 2012; 7(9):e44669. PubMed ID: 22957097
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.
    Neumann S; Claus M; Paschke R
    Eur J Endocrinol; 2005 Apr; 152(4):625-34. PubMed ID: 15817920
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties.
    Chen CR; McLachlan SM; Rapoport B
    Endocrinology; 2008 Jul; 149(7):3427-34. PubMed ID: 18388191
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of novel TSH interaction sites by systematic binding analysis of the TSHR hinge region.
    Mueller S; Szkudlinski MW; Schaarschmidt J; Günther R; Paschke R; Jaeschke H
    Endocrinology; 2011 Aug; 152(8):3268-78. PubMed ID: 21628383
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor.
    Kleinau G; Jaeschke H; Mueller S; Raaka BM; Neumann S; Paschke R; Krause G
    FASEB J; 2008 Aug; 22(8):2798-808. PubMed ID: 18381815
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evidence that the thyroid-stimulating hormone (TSH) receptor transmembrane domain influences kinetics of TSH binding to the receptor ectodomain.
    Chen CR; McLachlan SM; Rapoport B
    J Biol Chem; 2011 Feb; 286(8):6219-24. PubMed ID: 21190937
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity.
    Chen CR; Chazenbalk GD; McLachlan SM; Rapoport B
    Endocrinology; 2003 Apr; 144(4):1324-30. PubMed ID: 12639915
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.