These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Inhibition and modulation of gamma-secretase for Alzheimer's disease. Wolfe MS Neurotherapeutics; 2008 Jul; 5(3):391-8. PubMed ID: 18625450 [TBL] [Abstract][Full Text] [Related]
3. Gamma-secretase inhibition and modulation for Alzheimer's disease. Wolfe MS Curr Alzheimer Res; 2008 Apr; 5(2):158-64. PubMed ID: 18393800 [TBL] [Abstract][Full Text] [Related]
4. gamma-Secretase as a therapeutic target in Alzheimer's disease. Guardia-Laguarta C; Pera M; Lleó A Curr Drug Targets; 2010 Apr; 11(4):506-17. PubMed ID: 20015011 [TBL] [Abstract][Full Text] [Related]
5. Activity of gamma-secretase on substrates other than APP. Lleó A Curr Top Med Chem; 2008; 8(1):9-16. PubMed ID: 18220928 [TBL] [Abstract][Full Text] [Related]
6. γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not. Lessard CB; Rodriguez E; Ladd TB; Minter LM; Osborne BA; Miele L; Golde TE; Ran Y Alzheimers Res Ther; 2020 May; 12(1):61. PubMed ID: 32430033 [TBL] [Abstract][Full Text] [Related]
7. Substrate recruitment by γ-secretase. Fukumori A; Feilen LP; Steiner H Semin Cell Dev Biol; 2020 Sep; 105():54-63. PubMed ID: 32331992 [TBL] [Abstract][Full Text] [Related]
8. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein. Yang T; Arslanova D; Gu Y; Augelli-Szafran C; Xia W Mol Brain; 2008 Nov; 1():15. PubMed ID: 18983676 [TBL] [Abstract][Full Text] [Related]
9. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production. Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374 [TBL] [Abstract][Full Text] [Related]
11. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883 [TBL] [Abstract][Full Text] [Related]
12. Development and mechanism of γ-secretase modulators for Alzheimer's disease. Crump CJ; Johnson DS; Li YM Biochemistry; 2013 May; 52(19):3197-216. PubMed ID: 23614767 [TBL] [Abstract][Full Text] [Related]
14. γ-Secretase inhibitors and modulators for Alzheimer's disease. Wolfe MS J Neurochem; 2012 Jan; 120 Suppl 1(Suppl 1):89-98. PubMed ID: 22122056 [TBL] [Abstract][Full Text] [Related]
15. TASTPM mice expressing amyloid precursor protein and presenilin-1 mutant transgenes are sensitive to γ-secretase modulation and amyloid-β₄₂ lowering by GSM-10h. Hussain I; Harrison DC; Hawkins J; Chapman T; Marshall I; Facci L; Ahmed S; Brackenborough K; Skaper SD; Mead TL; Smith BB; Giblin GM; Hall A; Gonzalez MI; Richardson JC Neurodegener Dis; 2011; 8(1-2):15-24. PubMed ID: 20689247 [TBL] [Abstract][Full Text] [Related]
16. γ-Secretase as a target for Alzheimer's disease. Wolfe MS Adv Pharmacol; 2012; 64():127-53. PubMed ID: 22840746 [TBL] [Abstract][Full Text] [Related]
17. Secretase as a target for Alzheimer's disease. Wolfe MS Curr Top Med Chem; 2002 Apr; 2(4):371-83. PubMed ID: 11966461 [TBL] [Abstract][Full Text] [Related]
18. γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease. Nakayama K; Nagase H; Koh CS; Ohkawara T Cell Mol Neurobiol; 2011 Aug; 31(6):887-900. PubMed ID: 21516353 [TBL] [Abstract][Full Text] [Related]
19. Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage. Teranishi Y; Inoue M; Yamamoto NG; Kihara T; Wiehager B; Ishikawa T; Winblad B; Schedin-Weiss S; Frykman S; Tjernberg LO FEBS J; 2015 Sep; 282(17):3438-51. PubMed ID: 26094765 [TBL] [Abstract][Full Text] [Related]