These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

333 related articles for article (PubMed ID: 18221231)

  • 21. BACE-1 Inhibitors Targeting Alzheimer's Disease.
    Monteiro KLC; Dos Santos Alcântara MG; Freire NML; Brandão EM; do Nascimento VL; Dos Santos Viana LM; de Aquino TM; da Silva-Júnior EF
    Curr Alzheimer Res; 2023; 20(3):131-148. PubMed ID: 37309767
    [TBL] [Abstract][Full Text] [Related]  

  • 22. BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants.
    Timmers M; Barão S; Van Broeck B; Tesseur I; Slemmon J; De Waepenaert K; Bogert J; Shaw LM; Engelborghs S; Moechars D; Mercken M; Van Nueten L; Tritsmans L; de Strooper B; Streffer JR
    J Alzheimers Dis; 2017; 56(4):1437-1449. PubMed ID: 28157093
    [TBL] [Abstract][Full Text] [Related]  

  • 23. BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease.
    Moussa-Pacha NM; Abdin SM; Omar HA; Alniss H; Al-Tel TH
    Med Res Rev; 2020 Jan; 40(1):339-384. PubMed ID: 31347728
    [TBL] [Abstract][Full Text] [Related]  

  • 24. BACE: Therapeutic target and potential biomarker for Alzheimer's disease.
    Evin G; Barakat A; Masters CL
    Int J Biochem Cell Biol; 2010 Dec; 42(12):1923-6. PubMed ID: 20817005
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.
    Evin G
    BioDrugs; 2016 Jun; 30(3):173-94. PubMed ID: 27023706
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality.
    Ghosh AK; Bilcer G; Hong L; Koelsch G; Tang J
    Curr Alzheimer Res; 2007 Sep; 4(4):418-22. PubMed ID: 17908045
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Identification of a BACE1 Binding Peptide Candidate for the Prevention of Amyloid Beta in Alzheimer's Disease.
    Read J; Suphioglu C
    Cell Physiol Biochem; 2019; 53(2):413-428. PubMed ID: 31415717
    [TBL] [Abstract][Full Text] [Related]  

  • 28. A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.
    Neumann U; Rueeger H; Machauer R; Veenstra SJ; Lueoend RM; Tintelnot-Blomley M; Laue G; Beltz K; Vogg B; Schmid P; Frieauff W; Shimshek DR; Staufenbiel M; Jacobson LH
    Mol Neurodegener; 2015 Sep; 10():44. PubMed ID: 26336937
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
    Vassar R; Bennett BD; Babu-Khan S; Kahn S; Mendiaz EA; Denis P; Teplow DB; Ross S; Amarante P; Loeloff R; Luo Y; Fisher S; Fuller J; Edenson S; Lile J; Jarosinski MA; Biere AL; Curran E; Burgess T; Louis JC; Collins F; Treanor J; Rogers G; Citron M
    Science; 1999 Oct; 286(5440):735-41. PubMed ID: 10531052
    [TBL] [Abstract][Full Text] [Related]  

  • 30. A physicochemical descriptor based method for effective and rapid screening of dual inhibitors against BACE-1 and GSK-3β as targets for Alzheimer's disease.
    Kumar A; Srivastava G; Sharma A
    Comput Biol Chem; 2017 Dec; 71():1-9. PubMed ID: 28950235
    [TBL] [Abstract][Full Text] [Related]  

  • 31. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.
    Vassar R; Kovacs DM; Yan R; Wong PC
    J Neurosci; 2009 Oct; 29(41):12787-94. PubMed ID: 19828790
    [TBL] [Abstract][Full Text] [Related]  

  • 32. A Close Look at BACE1 Inhibitors for Alzheimer's Disease Treatment.
    Das B; Yan R
    CNS Drugs; 2019 Mar; 33(3):251-263. PubMed ID: 30830576
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.
    Georgievska B; Gustavsson S; Lundkvist J; Neelissen J; Eketjäll S; Ramberg V; Bueters T; Agerman K; Juréus A; Svensson S; Berg S; Fälting J; Lendahl U
    J Neurochem; 2015 Feb; 132(4):477-86. PubMed ID: 25156639
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease.
    Ghosh AK; Kumaragurubaran N; Tang J
    Curr Top Med Chem; 2005; 5(16):1609-22. PubMed ID: 16375745
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features.
    Shimmyo Y; Kihara T; Akaike A; Niidome T; Sugimoto H
    Biochim Biophys Acta; 2008 May; 1780(5):819-25. PubMed ID: 18295609
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
    Natunen T; Takalo M; Kemppainen S; Leskelä S; Marttinen M; Kurkinen KMA; Pursiheimo JP; Sarajärvi T; Viswanathan J; Gabbouj S; Solje E; Tahvanainen E; Pirttimäki T; Kurki M; Paananen J; Rauramaa T; Miettinen P; Mäkinen P; Leinonen V; Soininen H; Airenne K; Tanzi RE; Tanila H; Haapasalo A; Hiltunen M
    Neurobiol Dis; 2016 Jan; 85():187-205. PubMed ID: 26563932
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Interacting with γ-secretase for treating Alzheimer's disease: from inhibition to modulation.
    Panza F; Frisardi V; Solfrizzi V; Imbimbo BP; Logroscino G; Santamato A; Greco A; Seripa D; Pilotto A
    Curr Med Chem; 2011; 18(35):5430-47. PubMed ID: 22087836
    [TBL] [Abstract][Full Text] [Related]  

  • 38. BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells.
    Jämsä A; Belda O; Edlund M; Lindström E
    J Biomed Sci; 2011 Oct; 18(1):76. PubMed ID: 22018341
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils.
    Ortega A; Rincón Á; Jiménez-Aliaga KL; Bermejo-Bescós P; Martín-Aragón S; Molina MT; Csákÿ AG
    Bioorg Med Chem Lett; 2011 Apr; 21(8):2183-7. PubMed ID: 21441028
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Human beta-secretase (BACE) and BACE inhibitors: progress report.
    John V
    Curr Top Med Chem; 2006; 6(6):569-78. PubMed ID: 16712492
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 17.