BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 18221306)

  • 1. Three-dimensional quantitative structure-activity relationship modeling of gamma-secretase inhibitors using molecular field analysis.
    Sammi T; Silakari O; Ravikumar M
    Chem Biol Drug Des; 2008 Feb; 71(2):155-66. PubMed ID: 18221306
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 3D-QSAR studies of farnesyltransferase inhibitors: a comparative molecular field analysis approach.
    Puntambekar D; Giridhar R; Yadav MR
    Bioorg Med Chem Lett; 2006 Apr; 16(7):1821-7. PubMed ID: 16455255
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Self-organizing molecular field analysis on human β-secretase nonpeptide inhibitors: 5, 5-disubstituted aminohydantoins.
    Li Z; Zhou M; Wu F; Li R; Ding Z
    Eur J Med Chem; 2011 Jan; 46(1):58-64. PubMed ID: 21093114
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In silico prediction and screening of gamma-secretase inhibitors by molecular descriptors and machine learning methods.
    Yang XG; Lv W; Chen YZ; Xue Y
    J Comput Chem; 2010 Apr; 31(6):1249-58. PubMed ID: 19847781
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method.
    Temiz-Arpaci O; Tekiner-Gulbas B; Yildiz I; Aki-Sener E; Yalcin I
    Bioorg Med Chem; 2005 Dec; 13(23):6354-9. PubMed ID: 15993083
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 3D-QSAR studies on chromone derivatives as HIV-1 protease inhibitors: application of molecular field analysis.
    Nunthanavanit P; Anthony NG; Johnston BF; Mackay SP; Ungwitayatorn J
    Arch Pharm (Weinheim); 2008 Jun; 341(6):357-64. PubMed ID: 18442018
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human beta-secretase.
    Niu Y; Wang Y; Zou X; Yang X; Ma C; Lü Y; Zhou B; Yuan Y; Du G; Xu P
    Eur J Med Chem; 2010 May; 45(5):2089-94. PubMed ID: 20153560
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.
    Barrow JC; Stauffer SR; Rittle KE; Ngo PL; Yang Z; Selnick HG; Graham SL; Munshi S; McGaughey GB; Holloway MK; Simon AJ; Price EA; Sankaranarayanan S; Colussi D; Tugusheva K; Lai MT; Espeseth AS; Xu M; Huang Q; Wolfe A; Pietrak B; Zuck P; Levorse DA; Hazuda D; Vacca JP
    J Med Chem; 2008 Oct; 51(20):6259-62. PubMed ID: 18811140
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Binding interaction analysis of the active site and its inhibitors for neuraminidase (N1 subtype) of human influenza virus by the integration of molecular docking, FMO calculation and 3D-QSAR CoMFA modeling.
    Zhang Q; Yang J; Liang K; Feng L; Li S; Wan J; Xu X; Yang G; Liu D; Yang S
    J Chem Inf Model; 2008 Sep; 48(9):1802-12. PubMed ID: 18707092
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors.
    Liang H; Wu X; Yalowich JC; Hasinoff BB
    Mol Pharmacol; 2008 Mar; 73(3):686-96. PubMed ID: 18045852
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
    Schormann N; Senkovich O; Walker K; Wright DL; Anderson AC; Rosowsky A; Ananthan S; Shinkre B; Velu S; Chattopadhyay D
    Proteins; 2008 Dec; 73(4):889-901. PubMed ID: 18536013
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies of various benzodiazepine analogues of gamma-secretase inhibitors.
    Sammi T; Silakari O; Ravikumar M
    J Mol Model; 2009 Apr; 15(4):343-8. PubMed ID: 19067000
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Three-dimensional quantitative structure-activity relationship (3 D-QSAR) and docking studies on (benzothiazole-2-yl) acetonitrile derivatives as c-Jun N-terminal kinase-3 (JNK3) inhibitors.
    Shaikh AR; Ismael M; Del Carpio CA; Tsuboi H; Koyama M; Endou A; Kubo M; Broclawik E; Miyamoto A
    Bioorg Med Chem Lett; 2006 Nov; 16(22):5917-25. PubMed ID: 16989998
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of the structural requirements of the receptor-binding affinity of diphenolic azoles to estrogen receptors alpha and beta by three-dimensional quantitative structure-activity relationship and structure-activity relationship analysis.
    Demyttenaere-Kovatcheva A; Cronin MT; Benfenati E; Roncaglioni A; Lopiparo E
    J Med Chem; 2005 Dec; 48(24):7628-36. PubMed ID: 16302803
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent beta-secretase inhibitory leads.
    Al-Nadaf A; Abu Sheikha G; Taha MO
    Bioorg Med Chem; 2010 May; 18(9):3088-115. PubMed ID: 20378363
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of a novel series of Notch-sparing gamma-secretase inhibitors.
    Kreft A; Harrison B; Aschmies S; Atchison K; Casebier D; Cole DC; Diamantidis G; Ellingboe J; Hauze D; Hu Y; Huryn D; Jin M; Kubrak D; Lu P; Lundquist J; Mann C; Martone R; Moore W; Oganesian A; Porte A; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Woller K; Xu Z; Zhou H; Steven Jacobsen J
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4232-6. PubMed ID: 18556202
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Exploring three-dimensional quantitative structural activity relationship (3D-QSAR) analysis of SCH 66336 (Sarasar) analogues of farnesyltransferase inhibitors.
    Equbal T; Silakari O; Ravikumar M
    Eur J Med Chem; 2008 Jan; 43(1):204-9. PubMed ID: 17442459
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Quantitative structure-activity relationship studies on 1-aryl-tetrahydroisoquinoline analogs as active anti-HIV agents.
    Chen KX; Xie HY; Li ZG; Gao JR
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5381-6. PubMed ID: 18835162
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A method for induced-fit docking, scoring, and ranking of flexible ligands. Application to peptidic and pseudopeptidic beta-secretase (BACE 1) inhibitors.
    Moitessier N; Therrien E; Hanessian S
    J Med Chem; 2006 Oct; 49(20):5885-94. PubMed ID: 17004704
    [TBL] [Abstract][Full Text] [Related]  

  • 20. QSAR studies--potent benzodiazepine gamma-secretase inhibitors.
    Ravi Keerti A; Ashok Kumar B; Parthasarathy T; Uma V
    Bioorg Med Chem; 2005 Mar; 13(5):1873-8. PubMed ID: 15698805
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.