BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

287 related articles for article (PubMed ID: 18234110)

  • 1. Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.
    Gorman PM; Kim S; Guo M; Melnyk RA; McLaurin J; Fraser PE; Bowie JU; Chakrabartty A
    BMC Neurosci; 2008 Jan; 9():17. PubMed ID: 18234110
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues.
    Devkota S; Williams TD; Wolfe MS
    J Biol Chem; 2021; 296():100281. PubMed ID: 33450230
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
    Schilling S; Pradhan A; Heesch A; Helbig A; Blennow K; Koch C; Bertgen L; Koo EH; Brinkmalm G; Zetterberg H; Kins S; Eggert S
    Acta Neuropathol Commun; 2023 Jun; 11(1):87. PubMed ID: 37259128
    [TBL] [Abstract][Full Text] [Related]  

  • 4. GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.
    Munter LM; Voigt P; Harmeier A; Kaden D; Gottschalk KE; Weise C; Pipkorn R; Schaefer M; Langosch D; Multhaup G
    EMBO J; 2007 Mar; 26(6):1702-12. PubMed ID: 17332749
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
    Kim M; Bezprozvanny I
    Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide.
    Tang TC; Kienlen-Campard P; Hu Y; Perrin F; Opsomer R; Octave JN; Constantinescu SN; Smith SO
    J Biol Chem; 2019 Apr; 294(15):5854-5866. PubMed ID: 30755484
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites.
    Yan Y; Xu TH; Harikumar KG; Miller LJ; Melcher K; Xu HE
    J Biol Chem; 2017 Sep; 292(38):15826-15837. PubMed ID: 28790170
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
    Richter L; Munter LM; Ness J; Hildebrand PW; Dasari M; Unterreitmeier S; Bulic B; Beyermann M; Gust R; Reif B; Weggen S; Langosch D; Multhaup G
    Proc Natl Acad Sci U S A; 2010 Aug; 107(33):14597-602. PubMed ID: 20679249
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Designed Helical Peptides as Functional Probes for γ-Secretase.
    Philip AT; Devkota S; Malvankar S; Bhattarai S; Meneely KM; Williams TD; Wolfe MS
    Biochemistry; 2019 Nov; 58(44):4398-4407. PubMed ID: 31625391
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.
    Kienlen-Campard P; Tasiaux B; Van Hees J; Li M; Huysseune S; Sato T; Fei JZ; Aimoto S; Courtoy PJ; Smith SO; Constantinescu SN; Octave JN
    J Biol Chem; 2008 Mar; 283(12):7733-44. PubMed ID: 18201969
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.
    Munter LM; Botev A; Richter L; Hildebrand PW; Althoff V; Weise C; Kaden D; Multhaup G
    J Biol Chem; 2010 Jul; 285(28):21636-43. PubMed ID: 20452985
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A computer-simulated mechanism of familial Alzheimer's disease: Mutations enhance thermal dynamics and favor looser substrate-binding to γ-secretase.
    Dehury B; Somavarapu AK; Kepp KP
    J Struct Biol; 2020 Dec; 212(3):107648. PubMed ID: 33099014
    [TBL] [Abstract][Full Text] [Related]  

  • 13. APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.
    Bergman A; Religa D; Karlström H; Laudon H; Winblad B; Lannfelt L; Lundkvist J; Näslund J
    Exp Cell Res; 2003 Jul; 287(1):1-9. PubMed ID: 12799176
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.
    Arber C; Toombs J; Lovejoy C; Ryan NS; Paterson RW; Willumsen N; Gkanatsiou E; Portelius E; Blennow K; Heslegrave A; Schott JM; Hardy J; Lashley T; Fox NC; Zetterberg H; Wray S
    Mol Psychiatry; 2020 Nov; 25(11):2919-2931. PubMed ID: 30980041
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site.
    Chen W; Gamache E; Rosenman DJ; Xie J; Lopez MM; Li YM; Wang C
    Nat Commun; 2014; 5():3037. PubMed ID: 24390130
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
    Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
    J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
    [TBL] [Abstract][Full Text] [Related]  

  • 17. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
    McPhie DL; Golde T; Eckman CB; Yager D; Brant JB; Neve RL
    Brain Res Mol Brain Res; 2001 Dec; 97(1):103-13. PubMed ID: 11744168
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease.
    Wang H; Barreyro L; Provasi D; Djemil I; Torres-Arancivia C; Filizola M; Ubarretxena-Belandia I
    J Mol Biol; 2011 May; 408(5):879-95. PubMed ID: 21440556
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.
    Gerber H; Wu F; Dimitrov M; Garcia Osuna GM; Fraering PC
    J Biol Chem; 2017 Mar; 292(9):3751-3767. PubMed ID: 28096459
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.