202 related articles for article (PubMed ID: 18245773)
1. O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy.
Verbeek B; Southgate TD; Gilham DE; Margison GP
Br Med Bull; 2008; 85():17-33. PubMed ID: 18245773
[TBL] [Abstract][Full Text] [Related]
2. The specific role of O
Sun G; Zhao L; Zhong R; Peng Y
Future Med Chem; 2018 Aug; 10(16):1971-1996. PubMed ID: 30001630
[TBL] [Abstract][Full Text] [Related]
3. Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
Cai S; Xu Y; Cooper RJ; Ferkowicz MJ; Hartwell JR; Pollok KE; Kelley MR
Cancer Res; 2005 Apr; 65(8):3319-27. PubMed ID: 15833865
[TBL] [Abstract][Full Text] [Related]
4. Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage.
Paranjpe A; Zhang R; Ali-Osman F; Bobustuc GC; Srivenugopal KS
Carcinogenesis; 2014 Mar; 35(3):692-702. PubMed ID: 24193513
[TBL] [Abstract][Full Text] [Related]
5. Dual agent chemoprotection by retroviral co-expression of either MDR1 or MRP1 with the P140K mutant of O6-methylguanine-DNA-methyl transferase.
Southgate TD; Garside E; Margison GP; Fairbairn LJ
J Gene Med; 2006 Aug; 8(8):972-9. PubMed ID: 16733832
[TBL] [Abstract][Full Text] [Related]
6. Temozolomide: mechanisms of action, repair and resistance.
Zhang J; Stevens MF; Bradshaw TD
Curr Mol Pharmacol; 2012 Jan; 5(1):102-14. PubMed ID: 22122467
[TBL] [Abstract][Full Text] [Related]
7. S-alkylthiolation of O6-methylguanine-DNA-methyltransferase (MGMT) to sensitize cancer cells to anticancer therapy.
Juillerat A; Juillerat-Jeanneret L
Expert Opin Ther Targets; 2007 Mar; 11(3):349-61. PubMed ID: 17298293
[TBL] [Abstract][Full Text] [Related]
8. Targeting O⁶-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy.
Kaina B; Margison GP; Christmann M
Cell Mol Life Sci; 2010 Nov; 67(21):3663-81. PubMed ID: 20717836
[TBL] [Abstract][Full Text] [Related]
9. Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
Kokkinakis DM; Ahmed MM; Chendil D; Moschel RC; Pegg AE
Clin Cancer Res; 2003 Sep; 9(10 Pt 1):3801-7. PubMed ID: 14506174
[TBL] [Abstract][Full Text] [Related]
10. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.
Kaina B; Christmann M; Naumann S; Roos WP
DNA Repair (Amst); 2007 Aug; 6(8):1079-99. PubMed ID: 17485253
[TBL] [Abstract][Full Text] [Related]
11. O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
Bobola MS; Silber JR; Ellenbogen RG; Geyer JR; Blank A; Goff RD
Clin Cancer Res; 2005 Apr; 11(7):2747-55. PubMed ID: 15814657
[TBL] [Abstract][Full Text] [Related]
12. Analysis of O(6)-methylguanine-DNA methyltransferase in melanoma tumours in patients treated with dacarbazine-based chemotherapy.
Ma S; Egyházi S; Martenhed G; Ringborg U; Hansson J
Melanoma Res; 2002 Aug; 12(4):335-42. PubMed ID: 12170182
[TBL] [Abstract][Full Text] [Related]
13. Repair gene O
Aasland D; Reich TR; Tomicic MT; Switzeny OJ; Kaina B; Christmann M
J Neurochem; 2018 Jan; 144(2):139-151. PubMed ID: 29164620
[TBL] [Abstract][Full Text] [Related]
14. A novel approach to overcome temozolomide resistance in glioma and melanoma: Inactivation of MGMT by gene therapy.
Jiang G; Wei ZP; Pei DS; Xin Y; Liu YQ; Zheng JN
Biochem Biophys Res Commun; 2011 Mar; 406(3):311-4. PubMed ID: 21329652
[TBL] [Abstract][Full Text] [Related]
15. Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.
Schambach A; Baum C
DNA Repair (Amst); 2007 Aug; 6(8):1187-96. PubMed ID: 17482894
[TBL] [Abstract][Full Text] [Related]
16. O6-(4-bromothenyl)guanine (PaTrin-2), a novel inhibitor of O6-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro.
Turriziani M; Caporaso P; Bonmassar L; Buccisano F; Amadori S; Venditti A; Cantonetti M; D'Atri S; Bonmassar E
Pharmacol Res; 2006 Apr; 53(4):317-23. PubMed ID: 16412662
[TBL] [Abstract][Full Text] [Related]
17. Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity.
Hegi ME; Liu L; Herman JG; Stupp R; Wick W; Weller M; Mehta MP; Gilbert MR
J Clin Oncol; 2008 Sep; 26(25):4189-99. PubMed ID: 18757334
[TBL] [Abstract][Full Text] [Related]
18. Modulating MGMT expression through interfering with cell signaling pathways.
Bai P; Fan T; Wang X; Zhao L; Zhong R; Sun G
Biochem Pharmacol; 2023 Sep; 215():115726. PubMed ID: 37524206
[TBL] [Abstract][Full Text] [Related]
19. The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.
Remington M; Chtchetinin J; Ancheta K; Nghiemphu PL; Cloughesy T; Lai A
Neuro Oncol; 2009 Feb; 11(1):22-32. PubMed ID: 18812520
[TBL] [Abstract][Full Text] [Related]
20. Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
Göder A; Nagel G; Kraus A; Dörsam B; Seiwert N; Kaina B; Fahrer J
Carcinogenesis; 2015 Aug; 36(8):817-31. PubMed ID: 25998848
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
