These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

495 related articles for article (PubMed ID: 18248813)

  • 1. Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors.
    Dallavalle S; Gattinoni S; Mazzini S; Scaglioni L; Merlini L; Tinelli S; Beretta GL; Zunino F
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1484-9. PubMed ID: 18248813
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological activities of topopyrones.
    Zaleski PA; Maini R; Leiris SJ; Elban MA; Hecht SM
    J Nat Prod; 2012 Apr; 75(4):577-85. PubMed ID: 22462811
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
    Bailly C; Qu X; Chaires JB; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
    J Med Chem; 1999 Jul; 42(15):2927-35. PubMed ID: 10425102
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
    Basnet A; Thapa P; Karki R; Na Y; Jahng Y; Jeong BS; Jeong TC; Lee CS; Lee ES
    Bioorg Med Chem; 2007 Jul; 15(13):4351-9. PubMed ID: 17493824
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.
    Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
    Bioorg Med Chem Lett; 2004 Jul; 14(14):3659-63. PubMed ID: 15203138
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Total synthesis of topopyrones B and D.
    Tan JS; Ciufolini MA
    Org Lett; 2006 Oct; 8(21):4771-4. PubMed ID: 17020299
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and cytotoxic activity of substituted 7-aryliminomethyl derivatives of camptothecin.
    Dallavalle S; Merlini L; Morini G; Musso L; Penco S; Beretta GL; Tinelli S; Zunino F
    Eur J Med Chem; 2004 Jun; 39(6):507-13. PubMed ID: 15183909
    [TBL] [Abstract][Full Text] [Related]  

  • 8. L-proline analogues of anthraquinone-2-carboxylic acid: cytotoxic activity in breast cancer MCF-7 cells and inhibitory activity against topoisomerase I and II.
    Bielawska A; Kosk K; Bielawski K
    Pol J Pharmacol; 2001; 53(3):283-7. PubMed ID: 11785929
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
    Gamage SA; Spicer JA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1999 Jul; 42(13):2383-93. PubMed ID: 10395479
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents.
    Park HJ; Kim YS; Kim JS; Lee EJ; Yi YJ; Hwang HJ; Suh ME; Ryu CK; Lee SK
    Bioorg Med Chem Lett; 2004 Jul; 14(13):3385-8. PubMed ID: 15177438
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The topopyrones poison human DNA topoisomerases I and II.
    Khan QA; Elban MA; Hecht SM
    J Am Chem Soc; 2008 Oct; 130(39):12888-9. PubMed ID: 18774813
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors.
    Cho HJ; Jung MJ; Kwon Y; Na Y
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6766-9. PubMed ID: 19836231
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: indolizinoquinoline-5,12-dione derivatives.
    Cheng Y; An LK; Wu N; Wang XD; Bu XZ; Huang ZS; Gu LQ
    Bioorg Med Chem; 2008 Apr; 16(8):4617-25. PubMed ID: 18296054
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines.
    Karki R; Thapa P; Kang MJ; Jeong TC; Nam JM; Kim HL; Na Y; Cho WJ; Kwon Y; Lee ES
    Bioorg Med Chem; 2010 May; 18(9):3066-77. PubMed ID: 20392646
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.
    Zeng Q; Kwok Y; Kerwin SM; Mangold G; Hurley LH
    J Med Chem; 1998 Oct; 41(22):4273-8. PubMed ID: 9784102
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives.
    Nacro K; Zha CC; Guzzo PR; Jason Herr R; Peace D; Friedrich TD
    Bioorg Med Chem; 2007 Jun; 15(12):4237-46. PubMed ID: 17418582
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis, topoisomerase I inhibitory activity and in vitro cytotoxicity of camptothecin derivatives bearing five-membered heterocycle containing 10-substituents.
    Zhao R; Guan LL; Oreski B; Lown JW
    Anticancer Drug Des; 1998 Mar; 13(2):145-57. PubMed ID: 9524556
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin.
    Sunami S; Nishimura T; Nishimura I; Ito S; Arakawa H; Ohkubo M
    J Med Chem; 2009 May; 52(10):3225-37. PubMed ID: 19397324
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
    Gao H; Zhang X; Chen Y; Shen H; Pang T; Sun J; Xu C; Ding J; Li C; Lu W
    Bioorg Med Chem Lett; 2005 Jul; 15(13):3233-6. PubMed ID: 15913996
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel synthetic isoquinolino[5,4-ab]phenazines: inhibition toward topoisomerase I, antitumor and DNA photo-cleaving activities.
    Yang P; Yang Q; Qian X; Cui J
    Bioorg Med Chem; 2005 Nov; 13(21):5909-14. PubMed ID: 16115776
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 25.