These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

161 related articles for article (PubMed ID: 18251511)

  • 1. Fjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): structural basis for stereochemical preference.
    Shultz CA; Palackal NT; Mangal D; Harvey RG; Blair IA; Penning TM
    Chem Res Toxicol; 2008 Mar; 21(3):668-77. PubMed ID: 18251511
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis of fjord region tetraols and their use in hepatic biotransformation studies of dihydrodiols of benzo[c]chrysene, benzo[g]chrysene and dibenzo[a,l]pyrene.
    Luch A; Platt KL; Seidel A
    Carcinogenesis; 1998 Apr; 19(4):639-48. PubMed ID: 9600349
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons.
    Smithgall TE; Harvey RG; Penning TM
    J Biol Chem; 1986 May; 261(14):6184-91. PubMed ID: 3457793
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Conjugation of anti-dihydrodiol epoxides of benzo[a]pyrene, chrysene, benzo[c]phenanthrene and dibenz[a,h]anthracene with glutathione catalyzed by cytosol and by the Mu-class glutathione transferase HTP II from rat liver.
    Funk M; Gath I; Seidel A; Oesch F; Platt KL
    Chem Biol Interact; 1995 Mar; 95(1-2):189-201. PubMed ID: 7697750
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Stereoselective metabolism of chrysene by rat liver microsomes. Direct separation of diol enantiomers by chiral stationary phase h.p.l.c.
    Weems HB; Fu PP; Yang SK
    Carcinogenesis; 1986 Jul; 7(7):1221-30. PubMed ID: 3719913
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Oxidation of the trans-3,4-dihydrodiol metabolites of the potent carcinogen 7,12-dimethylbenz(a)anthracene and other benz(a)anthracene derivatives by 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase: effects of methyl substitution on velocity and stereochemical course of trans-dihydrodiol oxidation.
    Smithgall TE; Harvey RG; Penning TM
    Cancer Res; 1988 Mar; 48(5):1227-32. PubMed ID: 3124956
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In vitro reaction with DNA of the fjord-region diol epoxides of benzo[g]chrysene and benzo[c]phenanthrene as studied by 32P-postlabeling.
    Giles AS; Seidel A; Phillips DH
    Chem Res Toxicol; 1995 Jun; 8(4):591-9. PubMed ID: 7548740
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Regiospecific oxidation of polycyclic aromatic dihydrodiols by rat liver dihydrodiol dehydrogenase.
    Klein J; Seidel A; Frank H; Oesch F; Platt KL
    Chem Biol Interact; 1991; 79(3):287-303. PubMed ID: 1913974
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione.
    Burczynski ME; Harvey RG; Penning TM
    Biochemistry; 1998 May; 37(19):6781-90. PubMed ID: 9578563
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Selective activation of some dihydrodiols of several polycyclic aromatic hydrocarbons to mutagenic products by prostaglandin synthetase.
    Guthrie J; Robertson IG; Zeiger E; Boyd JA; Eling TE
    Cancer Res; 1982 May; 42(5):1620-3. PubMed ID: 6279279
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Microsomal metabolism of picene.
    Platt KL; Petrovic P; Seidel A; Beermann D; Oesch F
    Chem Biol Interact; 1988; 66(3-4):157-75. PubMed ID: 3396119
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation.
    Palackal NT; Burczynski ME; Harvey RG; Penning TM
    Biochemistry; 2001 Sep; 40(36):10901-10. PubMed ID: 11535067
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Stable expression of rat dihydrodiol dehydrogenase (AKR1C9) in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death.
    Tsuruda L; Hou Yt ; Penning TM
    Chem Res Toxicol; 2001 Jul; 14(7):856-62. PubMed ID: 11453732
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Different enzyme kinetics during the glutathione conjugation of the four stereoisomers of the fjord-region diolepoxides of benzo[c]phenanthrene by the mu-class rat liver glutathione S-transferase HTP II.
    Funk M; Gath I; Seidel A; Platt KL; Oesch F; Zeller HD
    Biochem Pharmacol; 1994 Feb; 47(3):505-14. PubMed ID: 8117319
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9).
    Heredia VV; Kruger RG; Penning TM
    Chem Biol Interact; 2003 Feb; 143-144():393-400. PubMed ID: 12604226
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Two K-regions of 5-methylchrysene are sites of oxidative metabolism.
    Bao Z; Yang SK
    Biochem Biophys Res Commun; 1986 Dec; 141(2):734-40. PubMed ID: 3801024
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and characterization of site-specific and stereoisomeric fjord dibenzo[a,l]pyrene diol epoxide-N(6)-adenine adducts: unusual thermal stabilization of modified DNA duplexes.
    Ruan Q; Kolbanovskiy A; Zhuang P; Chen J; Krzeminski J; Amin S; Geacintov NE
    Chem Res Toxicol; 2002 Feb; 15(2):249-61. PubMed ID: 11849052
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolic activation of racemic and enantiomeric trans-8, 9-dihydroxy-8,9-dihydrodibenzo[a,l]pyrene (dibenzo[def,p]chrysene) to dibenzo[a,l]pyrene-bis-dihydrodiols by induced rat liver microsomes and a recombinant human P450 1A1 system: the role of the K-region-derived metabolic intermediates in the formation of dibenzo[a,l]pyrene-DNA adducts.
    Nesnow S; Davis C; Padgett W; George M; Lambert G; Meyers F; Allison J; Adams L; King LC
    Chem Res Toxicol; 1998 Dec; 11(12):1596-607. PubMed ID: 9860506
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Stereoselective metabolism of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-3,4-dihydroxy-3,4-dihydrobenzo[c]-phenanthrene by rat and mouse liver microsomes and by a purified and reconstituted cytochrome P-450 system.
    Thakker DR; Levin W; Yagi H; Yeh HJ; Ryan DE; Thomas PE; Conney AH; Jerina DM
    J Biol Chem; 1986 Apr; 261(12):5404-13. PubMed ID: 3957930
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stereoselective formations of K-region and non-K-region epoxides in the metabolism of chrysene by rat liver microsomal cytochrome P-450 isozymes.
    Yang SK; Bao ZP
    Mol Pharmacol; 1987 Jul; 32(1):73-80. PubMed ID: 3037304
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.