210 related articles for article (PubMed ID: 18252207)
1. Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.
Liu Y; Millar JS; Cromley DA; Graham M; Crooke R; Billheimer JT; Rader DJ
Biochim Biophys Acta; 2008 Mar; 1781(3):97-104. PubMed ID: 18252207
[TBL] [Abstract][Full Text] [Related]
2. Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.
Yu XX; Murray SF; Pandey SK; Booten SL; Bao D; Song XZ; Kelly S; Chen S; McKay R; Monia BP; Bhanot S
Hepatology; 2005 Aug; 42(2):362-71. PubMed ID: 16001399
[TBL] [Abstract][Full Text] [Related]
3. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.
Qi J; Lang W; Geisler JG; Wang P; Petrounia I; Mai S; Smith C; Askari H; Struble GT; Williams R; Bhanot S; Monia BP; Bayoumy S; Grant E; Caldwell GW; Todd MJ; Liang Y; Gaul MD; Demarest KT; Connelly MA
J Lipid Res; 2012 Jun; 53(6):1106-16. PubMed ID: 22493088
[TBL] [Abstract][Full Text] [Related]
4. Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2.
Irshad Z; Chmel N; Adya R; Zammit VA
J Lipid Res; 2019 Jan; 60(1):111-120. PubMed ID: 30397187
[TBL] [Abstract][Full Text] [Related]
5. Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1.
Yamazaki T; Sasaki E; Kakinuma C; Yano T; Miura S; Ezaki O
J Biol Chem; 2005 Jun; 280(22):21506-14. PubMed ID: 15797871
[TBL] [Abstract][Full Text] [Related]
6. Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production.
Millar JS; Stone SJ; Tietge UJ; Tow B; Billheimer JT; Wong JS; Hamilton RL; Farese RV; Rader DJ
J Lipid Res; 2006 Oct; 47(10):2297-305. PubMed ID: 16877777
[TBL] [Abstract][Full Text] [Related]
7. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
Choi CS; Savage DB; Kulkarni A; Yu XX; Liu ZX; Morino K; Kim S; Distefano A; Samuel VT; Neschen S; Zhang D; Wang A; Zhang XM; Kahn M; Cline GW; Pandey SK; Geisler JG; Bhanot S; Monia BP; Shulman GI
J Biol Chem; 2007 Aug; 282(31):22678-88. PubMed ID: 17526931
[TBL] [Abstract][Full Text] [Related]
8. Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes.
Li C; Li L; Lian J; Watts R; Nelson R; Goodwin B; Lehner R
Arterioscler Thromb Vasc Biol; 2015 May; 35(5):1080-91. PubMed ID: 25792450
[TBL] [Abstract][Full Text] [Related]
9. The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.
Chitraju C; Walther TC; Farese RV
J Lipid Res; 2019 Jun; 60(6):1112-1120. PubMed ID: 30936184
[TBL] [Abstract][Full Text] [Related]
10. Intestinal acyl-CoA:diacylglycerol acyltransferase 2 overexpression enhances postprandial triglyceridemic response and exacerbates high fat diet-induced hepatic triacylglycerol storage.
Uchida A; Slipchenko MN; Eustaquio T; Leary JF; Cheng JX; Buhman KK
Biochim Biophys Acta; 2013 Aug; 1831(8):1377-85. PubMed ID: 23643496
[TBL] [Abstract][Full Text] [Related]
11. Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.
Malloy VL; Perrone CE; Mattocks DA; Ables GP; Caliendo NS; Orentreich DS; Orentreich N
Metabolism; 2013 Nov; 62(11):1651-61. PubMed ID: 23928105
[TBL] [Abstract][Full Text] [Related]
12. Up-regulation of hepatic Acyl CoA: Diacylglycerol acyltransferase-1 (DGAT-1) expression in nephrotic syndrome.
Vaziri ND; Kim CH; Phan D; Kim S; Liang K
Kidney Int; 2004 Jul; 66(1):262-7. PubMed ID: 15200432
[TBL] [Abstract][Full Text] [Related]
13. Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.
Liang JJ; Oelkers P; Guo C; Chu PC; Dixon JL; Ginsberg HN; Sturley SL
J Biol Chem; 2004 Oct; 279(43):44938-44. PubMed ID: 15308631
[TBL] [Abstract][Full Text] [Related]
14. Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism.
Song H; Zhu L; Picardo CM; Maguire G; Leung V; Connelly PW; Ng DS
Am J Physiol Endocrinol Metab; 2006 Jan; 290(1):E17-E25. PubMed ID: 16105858
[TBL] [Abstract][Full Text] [Related]
15. Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis.
Jin Y; McFie PJ; Banman SL; Brandt C; Stone SJ
J Biol Chem; 2014 Oct; 289(41):28237-48. PubMed ID: 25164810
[TBL] [Abstract][Full Text] [Related]
16. Pharmacological characterization of [trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl CoA:diacylglycerol transferase (DGAT) 1 inhibitor.
Tomimoto D; Okuma C; Ishii Y; Akiyama Y; Ohta T; Kakutani M; Ohkuma Y; Ogawa N
Biol Pharm Bull; 2015; 38(2):263-9. PubMed ID: 25747985
[TBL] [Abstract][Full Text] [Related]
17. Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin.
Meegalla RL; Billheimer JT; Cheng D
Biochem Biophys Res Commun; 2002 Nov; 298(3):317-23. PubMed ID: 12413942
[TBL] [Abstract][Full Text] [Related]
18. DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.
McLaren DG; Han S; Murphy BA; Wilsie L; Stout SJ; Zhou H; Roddy TP; Gorski JN; Metzger DE; Shin MK; Reilly DF; Zhou HH; Tadin-Strapps M; Bartz SR; Cumiskey AM; Graham TH; Shen DM; Akinsanya KO; Previs SF; Imbriglio JE; Pinto S
Cell Metab; 2018 Jun; 27(6):1236-1248.e6. PubMed ID: 29706567
[TBL] [Abstract][Full Text] [Related]
19. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.
Yamaguchi K; Yang L; McCall S; Huang J; Yu XX; Pandey SK; Bhanot S; Monia BP; Li YX; Diehl AM
Hepatology; 2007 Jun; 45(6):1366-74. PubMed ID: 17476695
[TBL] [Abstract][Full Text] [Related]
20. Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells.
Wurie HR; Buckett L; Zammit VA
FEBS J; 2012 Sep; 279(17):3033-47. PubMed ID: 22748069
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
