BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

267 related articles for article (PubMed ID: 18268076)

  • 21. Altered AZT (3'-azido-3'-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment.
    Engtrakul JJ; Foti RS; Strelevitz TJ; Fisher MB
    Drug Metab Dispos; 2005 Nov; 33(11):1621-7. PubMed ID: 16049128
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
    [TBL] [Abstract][Full Text] [Related]  

  • 23. In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.
    Yergey JA; Trimble LA; Silva J; Chauret N; Li C; Therien M; Grimm E; Nicoll-Griffith DA
    Drug Metab Dispos; 2001 May; 29(5):638-44. PubMed ID: 11302928
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.
    Kazmi F; Barbara JE; Yerino P; Parkinson A
    Drug Metab Dispos; 2015 Apr; 43(4):523-33. PubMed ID: 25595597
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
    Vidal C; Gómez-Hernández A; Sánchez-Galán E; González A; Ortega L; Gómez-Gerique JA; Tuñón J; Egido J
    J Pharmacol Exp Ther; 2007 Jan; 320(1):108-16. PubMed ID: 17015640
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.
    Koeberle A; Siemoneit U; Bühring U; Northoff H; Laufer S; Albrecht W; Werz O
    J Pharmacol Exp Ther; 2008 Sep; 326(3):975-82. PubMed ID: 18550688
    [TBL] [Abstract][Full Text] [Related]  

  • 27. In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP-glucuronosyltransferases.
    Tong Z; Li H; Goljer I; McConnell O; Chandrasekaran A
    Drug Metab Dispos; 2007 Dec; 35(12):2203-10. PubMed ID: 17875670
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Licofelone, a dual lipoxygenase-cyclooxygenase inhibitor, downregulates polymorphonuclear leukocyte and platelet function.
    Rotondo S; Dell'Elba G; Krauze-Brzósko K; Manarini S; Martelli N; Pecce R; Evangelista V; Cerletti C
    Eur J Pharmacol; 2002 Oct; 453(1):131-9. PubMed ID: 12393068
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Identification of a novel N-carbamoyl glucuronide: in vitro, in vivo, and mechanistic studies.
    Gunduz M; Argikar UA; Baeschlin D; Ferreira S; Hosagrahara V; Harriman S
    Drug Metab Dispos; 2010 Mar; 38(3):361-7. PubMed ID: 20008038
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.
    Ulbrich H; Soehnlein O; Xie X; Eriksson EE; Lindbom L; Albrecht W; Laufer S; Dannhardt G
    Biochem Pharmacol; 2005 Jul; 70(1):30-6. PubMed ID: 15894291
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor.
    Wong H; Chen JZ; Chou B; Halladay JS; Kenny JR; La H; Marsters JC; Plise E; Rudewicz PJ; Robarge K; Shin Y; Wong S; Zhang C; Khojasteh SC
    Xenobiotica; 2009 Nov; 39(11):850-61. PubMed ID: 19845436
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.
    Mohammed A; Janakiram NB; Li Q; Choi CI; Zhang Y; Steele VE; Rao CV
    Cancer Prev Res (Phila); 2011 Dec; 4(12):2015-26. PubMed ID: 21885812
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation.
    Hanioka N; Naito T; Narimatsu S
    Chemosphere; 2008 Dec; 74(1):33-6. PubMed ID: 18990428
    [TBL] [Abstract][Full Text] [Related]  

  • 34. UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat.
    Daidoji T; Gozu K; Iwano H; Inoue H; Yokota H
    Drug Metab Dispos; 2005 Oct; 33(10):1466-76. PubMed ID: 16006569
    [TBL] [Abstract][Full Text] [Related]  

  • 35. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes.
    Lapham K; Callegari E; Cianfrogna J; Lin J; Niosi M; Orozco CC; Sharma R; Goosen TC
    Drug Metab Dispos; 2020 Dec; 48(12):1350-1363. PubMed ID: 33020067
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7.
    Gaganis P; Miners JO; Knights KM
    Biochem Pharmacol; 2007 May; 73(10):1683-91. PubMed ID: 17343829
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Product inhibition of UDP-glucuronosyltransferase (UGT) enzymes by UDP obfuscates the inhibitory effects of UGT substrates.
    Fujiwara R; Nakajima M; Yamanaka H; Katoh M; Yokoi T
    Drug Metab Dispos; 2008 Feb; 36(2):361-7. PubMed ID: 17998297
    [TBL] [Abstract][Full Text] [Related]  

  • 38. In vitro characterisation of human renal and hepatic frusemide glucuronidation and identification of the UDP-glucuronosyltransferase enzymes involved in this pathway.
    Kerdpin O; Knights KM; Elliot DJ; Miners JO
    Biochem Pharmacol; 2008 Jul; 76(2):249-57. PubMed ID: 18541222
    [TBL] [Abstract][Full Text] [Related]  

  • 39. In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rat, monkey, and human liver microsomes and freshly isolated hepatocytes.
    Uchiyama M; Koda H; Fischer T; Mueller J; Yamamura N; Oguchi M; Iwabuchi H; Okazaki O; Izumi T
    Drug Metab Dispos; 2011 Jul; 39(7):1311-9. PubMed ID: 21511943
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.
    Gay RE; Neidhart M; Pataky F; Tries S; Laufer S; Gay S
    J Rheumatol; 2001 Sep; 28(9):2060-5. PubMed ID: 11550975
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.