148 related articles for article (PubMed ID: 18272371)
1. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
Reddy MV; Billa VK; Pallela VR; Mallireddigari MR; Boominathan R; Gabriel JL; Reddy EP
Bioorg Med Chem; 2008 Apr; 16(7):3907-16. PubMed ID: 18272371
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN; Chen QH; Knaus EE
J Med Chem; 2006 Mar; 49(5):1668-83. PubMed ID: 16509583
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
Cusan C; Spalluto G; Prato M; Adams M; Bodensieck A; Bauer R; Tubaro A; Bernardi P; Da Ros T
Farmaco; 2005 Apr; 60(4):327-32. PubMed ID: 15848208
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
Chen QH; Rao PN; Knaus EE
Bioorg Med Chem; 2006 Dec; 14(23):7898-909. PubMed ID: 16904331
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
Cusan C; Spalluto G; Prato M; Adams M; Bodensieck A; Bauer R; Tubaro A; Bernardi P; Da Ros T
Farmaco; 2005 Jan; 60(1):7-13. PubMed ID: 15652362
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases.
Moreau A; Chen QH; Praveen Rao PN; Knaus EE
Bioorg Med Chem; 2006 Dec; 14(23):7716-27. PubMed ID: 16931030
[TBL] [Abstract][Full Text] [Related]
7. Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and 3D-QSAR analyses on DHDMBF analogues.
Zheng M; Zhang Z; Zhu W; Liu H; Luo X; Chen K; Jiang H
Bioorg Med Chem; 2006 May; 14(10):3428-37. PubMed ID: 16458008
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: a novel class of cyclooxygenase-2 inhibitors.
Chen QH; Rao PN; Knaus EE
Bioorg Med Chem; 2005 Dec; 13(23):6425-34. PubMed ID: 16099663
[TBL] [Abstract][Full Text] [Related]
9. Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.
Navidpour L; Amini M; Shafaroodi H; Abdi K; Ghahremani MH; Dehpour AR; Shafiee A
Bioorg Med Chem Lett; 2006 Sep; 16(17):4483-7. PubMed ID: 16806914
[TBL] [Abstract][Full Text] [Related]
10. Rationalization of physicochemical characters of 1,5-diarylpyrazole analogs as dual (COX-2/LOX-5) inhibitors: a QSAR approach.
Revathi S; Gupta AK; Soni LK; Kavitha S; Wagh R; Kaskhedikar SG
J Pharm Biomed Anal; 2006 Sep; 42(2):283-9. PubMed ID: 16781106
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and biological evaluation of acyclic triaryl (Z)-olefins possessing a 3,5-di-tert-butyl-4-hydroxyphenyl pharmacophore: dual inhibitors of cyclooxygenases and lipoxygenases.
Moreau A; Rao PN; Knaus EE
Bioorg Med Chem; 2006 Aug; 14(15):5340-50. PubMed ID: 16677817
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN; Chen QH; Knaus EE
Bioorg Med Chem Lett; 2005 Nov; 15(21):4842-5. PubMed ID: 16143531
[TBL] [Abstract][Full Text] [Related]
13. Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.
Tsai WJ; Shiao YJ; Lin SJ; Chiou WF; Lin LC; Yang TH; Teng CM; Wu TS; Yang LM
Bioorg Med Chem Lett; 2006 Sep; 16(17):4440-3. PubMed ID: 16814546
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives.
Li MH; Yin LL; Cai MJ; Zhang WY; Huang Y; Wang X; Zhu XZ; Shen JK
Acta Pharmacol Sin; 2005 Jul; 26(7):865-72. PubMed ID: 15960895
[TBL] [Abstract][Full Text] [Related]
15. 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile.
Sakya SM; Hou X; Minich ML; Rast B; Shavnya A; DeMello KM; Cheng H; Li J; Jaynes BH; Mann DW; Petras CF; Seibel SB; Haven ML
Bioorg Med Chem Lett; 2007 Feb; 17(4):1067-72. PubMed ID: 17126015
[TBL] [Abstract][Full Text] [Related]
16. Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors.
Khanna S; Madan M; Vangoori A; Banerjee R; Thaimattam R; Jafar Sadik Basha SK; Ramesh M; Casturi SR; Pal M
Bioorg Med Chem; 2006 Jul; 14(14):4820-33. PubMed ID: 16581252
[TBL] [Abstract][Full Text] [Related]
17. 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers.
Sakya SM; Cheng H; Lundy Demello KM; Shavnya A; Minich ML; Rast B; Dutra J; Li C; Rafka RJ; Koss DA; Li J; Jaynes BH; Ziegler CB; Mann DW; Petras CF; Seibel SB; Silvia AM; George DM; Hickman A; Haven ML; Lynch MP
Bioorg Med Chem Lett; 2006 Mar; 16(5):1202-6. PubMed ID: 16380252
[TBL] [Abstract][Full Text] [Related]
18. Design, syntheses, biological evaluation, and docking studies of 2-substituted 5-methylsulfonyl-1-phenyl-1H-indoles: potent and selective in vitro cyclooxygenase-2 inhibitors.
Cruz-López O; Díaz-Mochón JJ; Campos JM; Entrena A; Núñez MT; Labeaga L; Orjales A; Gallo MA; Espinosa A
ChemMedChem; 2007 Jan; 2(1):88-100. PubMed ID: 17131462
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors.
Cheng H; Lundy DeMello KM; Li J; Sakya SM; Ando K; Kawamura K; Kato T; Rafka RJ; Jaynes BH; Ziegler CB; Stevens R; Lund LA; Mann DW; Kilroy C; Haven ML; Nimz EL; Dutra JK; Li C; Minich ML; Kolosko NL; Petras C; Silvia AM; Seibel SB
Bioorg Med Chem Lett; 2006 Apr; 16(8):2076-80. PubMed ID: 16464588
[TBL] [Abstract][Full Text] [Related]
20. 3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.
Ranatunge RR; Earl RA; Garvey DS; Janero DR; Letts LG; Martino AM; Murty MG; Richardson SK; Schwalb DJ; Young DV; Zemtseva IS
Bioorg Med Chem Lett; 2004 Dec; 14(24):6049-52. PubMed ID: 15546727
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
