108 related articles for article (PubMed ID: 18275133)
1. Potent inhibitors of the hedgehog signaling pathway.
Brunton SA; Stibbard JH; Rubin LL; Kruse LI; Guicherit OM; Boyd EA; Price S
J Med Chem; 2008 Mar; 51(5):1108-10. PubMed ID: 18275133
[TBL] [Abstract][Full Text] [Related]
2. Potent agonists of the Hedgehog signaling pathway.
Brunton SA; Stibbard JH; Rubin LL; Guicherit OM; Kruse LI; Price S; di Lucrezia R; MacKinnon CH; Avery A; Park Y; Buxton D; Boyd EA
Bioorg Med Chem Lett; 2009 Aug; 19(15):4308-11. PubMed ID: 19500978
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors.
Bhattarai D; Jung JH; Han S; Lee H; Oh SJ; Ko HW; Lee K
Eur J Med Chem; 2017 Jan; 125():1036-1050. PubMed ID: 27810591
[TBL] [Abstract][Full Text] [Related]
4. GDC-0449-a potent inhibitor of the hedgehog pathway.
Robarge KD; Brunton SA; Castanedo GM; Cui Y; Dina MS; Goldsmith R; Gould SE; Guichert O; Gunzner JL; Halladay J; Jia W; Khojasteh C; Koehler MF; Kotkow K; La H; Lalonde RL; Lau K; Lee L; Marshall D; Marsters JC; Murray LJ; Qian C; Rubin LL; Salphati L; Stanley MS; Stibbard JH; Sutherlin DP; Ubhayaker S; Wang S; Wong S; Xie M
Bioorg Med Chem Lett; 2009 Oct; 19(19):5576-81. PubMed ID: 19716296
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors.
Fang X; Chen YT; Sessions EH; Chowdhury S; Vojkovsky T; Yin Y; Pocas JR; Grant W; Schröter T; Lin L; Ruiz C; Cameron MD; LoGrasso P; Bannister TD; Feng Y
Bioorg Med Chem Lett; 2011 Mar; 21(6):1844-8. PubMed ID: 21349713
[TBL] [Abstract][Full Text] [Related]
6. Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
Ontoria JM; Bufi LL; Torrisi C; Bresciani A; Giomini C; Rowley M; Serafini S; Bin H; Hao W; Steinkühler C; Jones P
Bioorg Med Chem Lett; 2011 Sep; 21(18):5274-82. PubMed ID: 21803580
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and cytotoxicity testing of novel 2-(3-substituted-6-chloro-1,1-dioxo-1,4,2-benzodithiazin-7-yl)-3-phenyl-4(3H)-quinazolinones.
Pomarnacka E; Maruszak M; Langowska K; Reszka P; Bednarski PJ
Arch Pharm (Weinheim); 2008 Aug; 341(8):485-90. PubMed ID: 18618486
[TBL] [Abstract][Full Text] [Related]
8. 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.
Duan H; Zheng J; Lai Q; Liu Z; Tian G; Wang Z; Li J; Shen J
Bioorg Med Chem Lett; 2009 May; 19(10):2777-9. PubMed ID: 19375311
[TBL] [Abstract][Full Text] [Related]
9. Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase.
Hattori K; Kido Y; Yamamoto H; Ishida J; Iwashita A; Mihara K
Bioorg Med Chem Lett; 2007 Oct; 17(20):5577-81. PubMed ID: 17804225
[TBL] [Abstract][Full Text] [Related]
10. Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.
Tremblay MR; Nevalainen M; Nair SJ; Porter JR; Castro AC; Behnke ML; Yu LC; Hagel M; White K; Faia K; Grenier L; Campbell MJ; Cushing J; Woodward CN; Hoyt J; Foley MA; Read MA; Sydor JR; Tong JK; Palombella VJ; McGovern K; Adams J
J Med Chem; 2008 Nov; 51(21):6646-9. PubMed ID: 18842035
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists.
Nagase T; Mizutani T; Ishikawa S; Sekino E; Sasaki T; Fujimura T; Ito S; Mitobe Y; Miyamoto Y; Yoshimoto R; Tanaka T; Ishihara A; Takenaga N; Tokita S; Fukami T; Sato N
J Med Chem; 2008 Aug; 51(15):4780-9. PubMed ID: 18598020
[TBL] [Abstract][Full Text] [Related]
12. The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.
Cupido T; Rack PG; Firestone AJ; Hyman JM; Han K; Sinha S; Ocasio CA; Chen JK
Angew Chem Int Ed Engl; 2009; 48(13):2321-4. PubMed ID: 19222062
[TBL] [Abstract][Full Text] [Related]
13. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
Tremblay MR; Lescarbeau A; Grogan MJ; Tan E; Lin G; Austad BC; Yu LC; Behnke ML; Nair SJ; Hagel M; White K; Conley J; Manna JD; Alvarez-Diez TM; Hoyt J; Woodward CN; Sydor JR; Pink M; MacDougall J; Campbell MJ; Cushing J; Ferguson J; Curtis MS; McGovern K; Read MA; Palombella VJ; Adams J; Castro AC
J Med Chem; 2009 Jul; 52(14):4400-18. PubMed ID: 19522463
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists.
Storelli S; Verzijl D; Al-Badie J; Elders N; Bosch L; Timmerman H; Smit MJ; De Esch IJ; Leurs R
Arch Pharm (Weinheim); 2007 Jun; 340(6):281-91. PubMed ID: 17562560
[TBL] [Abstract][Full Text] [Related]
15. Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3.
Johnson M; Li AR; Liu J; Fu Z; Zhu L; Miao S; Wang X; Xu Q; Huang A; Marcus A; Xu F; Ebsworth K; Sablan E; Danao J; Kumer J; Dairaghi D; Lawrence C; Sullivan T; Tonn G; Schall T; Collins T; Medina J
Bioorg Med Chem Lett; 2007 Jun; 17(12):3339-43. PubMed ID: 17448658
[TBL] [Abstract][Full Text] [Related]
16. Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.
Tremblay MR; Nesler M; Weatherhead R; Castro AC
Expert Opin Ther Pat; 2009 Aug; 19(8):1039-56. PubMed ID: 19505195
[TBL] [Abstract][Full Text] [Related]
17. Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway.
Castanedo GM; Wang S; Robarge KD; Blackwood E; Burdick D; Chang C; Dijkgraaf GJ; Gould S; Gunzner J; Guichert O; Halladay J; Khojasteh C; Lee L; Marsters JC; Murray L; Peterson D; Plise E; Salphati L; de Sauvage FJ; Wong S; Sutherlin DP
Bioorg Med Chem Lett; 2010 Nov; 20(22):6748-53. PubMed ID: 20875741
[TBL] [Abstract][Full Text] [Related]
18. Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1.
Malancona S; Altamura S; Filocamo G; Kinzel O; Hernando JI; Rowley M; Scarpelli R; Steinkühler C; Jones P
Bioorg Med Chem Lett; 2011 Aug; 21(15):4422-8. PubMed ID: 21737272
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists.
Nagase T; Mizutani T; Sekino E; Ishikawa S; Ito S; Mitobe Y; Miyamoto Y; Yoshimoto R; Tanaka T; Ishihara A; Takenaga N; Tokita S; Sato N
J Med Chem; 2008 Nov; 51(21):6889-901. PubMed ID: 18841880
[TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine.
Winkler JD; Isaacs A; Holderbaum L; Tatard V; Dahmane N
Org Lett; 2009 Jul; 11(13):2824-7. PubMed ID: 19552464
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
