217 related articles for article (PubMed ID: 18279716)
1. In vivo selection of hematopoietic stem cells transduced at a low multiplicity-of-infection with a foamy viral MGMT(P140K) vector.
Cai S; Ernstberger A; Wang H; Bailey BJ; Hartwell JR; Sinn AL; Eckermann O; Linka Y; Goebel WS; Hanenberg H; Pollok KE
Exp Hematol; 2008 Mar; 36(3):283-92. PubMed ID: 18279716
[TBL] [Abstract][Full Text] [Related]
2. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
Ragg S; Xu-Welliver M; Bailey J; D'Souza M; Cooper R; Chandra S; Seshadri R; Pegg AE; Williams DA
Cancer Res; 2000 Sep; 60(18):5187-95. PubMed ID: 11016647
[TBL] [Abstract][Full Text] [Related]
3. Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells.
Jansen M; Sorg UR; Ragg S; Flasshove M; Seeber S; Williams DA; Moritz T
Cancer Gene Ther; 2002 Sep; 9(9):737-46. PubMed ID: 12189523
[TBL] [Abstract][Full Text] [Related]
4. In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning.
Zielske SP; Reese JS; Lingas KT; Donze JR; Gerson SL
J Clin Invest; 2003 Nov; 112(10):1561-70. PubMed ID: 14617757
[TBL] [Abstract][Full Text] [Related]
5. Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow.
Kramer BA; Lemckert FA; Alexander IE; Gunning PW; McCowage GB
J Gene Med; 2006 Sep; 8(9):1071-85. PubMed ID: 16927363
[TBL] [Abstract][Full Text] [Related]
6. Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients.
Bowman JE; Reese JS; Lingas KT; Gerson SL
Mol Ther; 2003 Jul; 8(1):42-50. PubMed ID: 12842427
[TBL] [Abstract][Full Text] [Related]
7. Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro.
Zielske SP; Gerson SL
Mol Ther; 2002 Apr; 5(4):381-7. PubMed ID: 11945064
[TBL] [Abstract][Full Text] [Related]
8. Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
Kreklau EL; Pollok KE; Bailey BJ; Liu N; Hartwell JR; Williams DA; Erickson LC
Mol Cancer Ther; 2003 Dec; 2(12):1321-9. PubMed ID: 14707273
[TBL] [Abstract][Full Text] [Related]
9. Efficiency and safety of O⁶-methylguanine DNA methyltransferase (MGMT(P140K))-mediated in vivo selection in a humanized mouse model.
Phaltane R; Haemmerle R; Rothe M; Modlich U; Moritz T
Hum Gene Ther; 2014 Feb; 25(2):144-55. PubMed ID: 24218991
[TBL] [Abstract][Full Text] [Related]
10. Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients.
Davis BM; Reese JS; Lingas K; Gerson SL
J Hematother Stem Cell Res; 2003 Aug; 12(4):375-87. PubMed ID: 12965075
[TBL] [Abstract][Full Text] [Related]
11. In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells.
Cai S; Hartwell JR; Cooper RJ; Juliar BE; Kreklau E; Abonour R; Goebel WS; Pollok KE
Mol Ther; 2006 May; 13(5):1016-26. PubMed ID: 16426896
[TBL] [Abstract][Full Text] [Related]
12. MGMT enrichment and second gene co-expression in hematopoietic progenitor cells using separate or dual-gene lentiviral vectors.
Roth JC; Alberti MO; Ismail M; Lingas KT; Reese JS; Gerson SL
Virus Res; 2015 Jan; 196():170-80. PubMed ID: 25479595
[TBL] [Abstract][Full Text] [Related]
13. Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells.
Milsom MD; Jerabek-Willemsen M; Harris CE; Schambach A; Broun E; Bailey J; Jansen M; Schleimer D; Nattamai K; Wilhelm J; Watson A; Geiger H; Margison GP; Moritz T; Baum C; Thomale J; Williams DA
Cancer Res; 2008 Aug; 68(15):6171-80. PubMed ID: 18676840
[TBL] [Abstract][Full Text] [Related]
14. Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression.
Ball CR; Pilz IH; Schmidt M; Fessler S; Williams DA; von Kalle C; Glimm H
Blood; 2007 Sep; 110(6):1779-87. PubMed ID: 17496202
[TBL] [Abstract][Full Text] [Related]
15. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
Davis BM; Reese JS; Koç ON; Lee K; Schupp JE; Gerson SL
Cancer Res; 1997 Nov; 57(22):5093-9. PubMed ID: 9371508
[TBL] [Abstract][Full Text] [Related]
16. Imaging stem cell-derived persistent foci after in vivo selection of lentiviral MGMT-P140K transduced murine bone marrow cells.
Lin Y; Cheung P; Roth JC; Wilson DL; Gerson SL
Mol Ther; 2011 Jul; 19(7):1342-52. PubMed ID: 21304493
[TBL] [Abstract][Full Text] [Related]
17. In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication.
Davis BM; Humeau L; Dropulic B
Mol Ther; 2004 Feb; 9(2):160-72. PubMed ID: 14759800
[TBL] [Abstract][Full Text] [Related]
18. Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression.
Falahati R; Zhang J; Flebbe-Rehwaldt L; Shi Y; Gerson SL; Gaensler KM
Mol Ther; 2012 Nov; 20(11):2180-9. PubMed ID: 22871662
[TBL] [Abstract][Full Text] [Related]
19. Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.
Lee AS; Kahatapitiya P; Kramer B; Joya JE; Hook J; Liu R; Schevzov G; Alexander IE; McCowage G; Montarras D; Gunning PW; Hardeman EC
Stem Cells; 2009 May; 27(5):1098-108. PubMed ID: 19415780
[TBL] [Abstract][Full Text] [Related]
20. The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine.
Woolford LB; Southgate TD; Margison GP; Milsom MD; Fairbairn LJ
J Gene Med; 2006 Jan; 8(1):29-34. PubMed ID: 16075413
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
